RXRA introne polymorphism and ABO blood groups in chronic heart failure

PÁVKOVÁ GOLDBERGOVÁ, Monika, Lenka ŠPINAROVÁ, Jindřich ŠPINAR, Jiří VÍTOVEC, Jiří PAŘENICA, Martin POLOCZEK and Anna VAŠKŮ. RXRA introne polymorphism and ABO blood groups in chronic heart failure. Cent. Eur. J. Biol. 2010, vol. 6, No 5, 8 pp. ISSN 1895-104X.

Basic information

• Original name: RXRA introne polymorphism and ABO blood groups in chronic heart failure
• Authors: PÁVKOVÁ GOLDBERGOVÁ, Monika (203 Czech Republic, guarantor, belonging to the institution), Lenka ŠPINAROVÁ (203 Czech Republic, belonging to the institution), Jindřich ŠPINAR (203 Czech Republic, belonging to the institution), Jiří VÍTOVEC (203 Czech Republic, belonging to the institution), Jiří PAŘENICA (203 Czech Republic, belonging to the institution), Martin POLOCZEK (203 Czech Republic, belonging to the institution) and Anna VAŠKŮ (203 Czech Republic, belonging to the institution).
• Edition: Cent. Eur. J. Biol, 2010, 1895-104X.

Other information

• Original language: English
• Type of outcome: Article in a journal
• Field of Study: Genetics and molecular biology
• Country of publisher: Poland
• Confidentiality degree: is not subject to a state or trade secret
• Impact factor: Impact factor: 0.685
• RIV identification code: RIV/00216224:14110/10:00040799
• Organization unit: Faculty of Medicine
• UT WoS: 000282127800002
• Keywords in English: gene; polymorphism; rxr; blood group

Abstract

Retinoic X receptor alpha (RXRA), a member of nuclear receptor superfamily, plays a key role in development, metabolism, glucose homeostasis, and intestinal cholesterol balance. The aim of this study was to examine an association of RXR alpha introne 5 A(39526)AA polymorphism and ABO blood groups with chronic heart failure (CHF) in the Czech population. A total of 238 patients with chronic heart failure and a control group of 246 subjects were included in the study. The RXR alpha gene polymorphism and ABO blood groups were detected by PCR and RFLP methods. Significant differences in distributions of RXRA A(39526)AA alleles and genotypes between CHF patients and controls were observed (Pg=0.03, Pa=0.02). The RXRA gene polymorphism differences of within blood group A between CHF patients and controls were highly significant in genotype distributions (Pg=0.002) and in allele frequency comparisons (Pa=0.0001). The prevalence of AA allele in CHF patients with A blood group was four-fold lower than in controls with the same blood group (OR=0.24; Pcorr=0.0001). A highly significant association of RXRA introne single-nucleotide insertion polymorphism and A blood group in chronic heart failure was observed. Our results suggest close linkage between RXRA A(39526)AA polymorphism and ABO blood groups.

Links

• NR9356, research and development project: Name: Komplexní zhodnocení vlivu polymorfismu matrix metalloproteináz-1,2,3,9, tkáńového inhibitoru matrix metaloproteináz-1 a ACE na remodelaci levé komory a střednědobou prognózu po akutním infarktu mykardu s ST elevacemi léčeném primární PCI

Investor: Ministry of Health of the CR, Complex estimation of relation of MMP-1,2,3,9,TIMP-1 and ACE polymorphisms to left ventricuzlar remodelation and to medium-term prognosis after acute infarct myocardum with ST elevation treated by primary PCI