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@proceedings{905265, author = {Knopfová, Lucia and Pekarčíková, Lucie and Beneš, Petr and Šmarda, Jan}, booktitle = {Frontiers in Tumour Progression}, keywords = {c-Myb; migration; breast carcinoma; colon carcinoma}, language = {eng}, title = {c-Myb-induced migration and invasiveness of breast and colon cancer cells are associated with up-regulation of cathepsin D}, year = {2010} }
TY - CONF ID - 905265 AU - Knopfová, Lucia - Pekarčíková, Lucie - Beneš, Petr - Šmarda, Jan PY - 2010 TI - c-Myb-induced migration and invasiveness of breast and colon cancer cells are associated with up-regulation of cathepsin D KW - c-Myb KW - migration KW - breast carcinoma KW - colon carcinoma N2 - c-Myb is essential regulator of stem-progenitor cells in bone marrow, colon epithelia and neurogenic niches in brain. Malfunction of c-Myb results in malignancies of several types including breast and colon cancer. Its role in control of invasion and metastasis of tumor cells remains unclear. This study shows that overexpession of c-Myb enhances ability of human breast cancer MDA-MB-231 cells and mouse colon cancer CT26 cells to migrate and invade Matrigel in vitro. Real-time analysis of cell migration and invasion using the xCELLigence RTCA system revealed dynamics of c-Myb-induced effects with rapid onset of migration and invasion during first 6 and 12 hours, respectively. Real-time PCR screening revealed up-regulation of cathepsin D and matrix metalloproteinase 9 (MMP9) mRNAs coding for proteases that promote invasive behavior in c-Myb-overexpressing cells. Further experiments confirmed that increased production of cathepsin D and MMP 9 correlate with c-Myb-induced invasivity of MDA-MB-231 cells. ER -
KNOPFOVÁ, Lucia, Lucie PEKARČÍKOVÁ, Petr BENEŠ a Jan ŠMARDA. c-Myb-induced migration and invasiveness of breast and colon cancer cells are associated with up-regulation of cathepsin D. In \textit{Frontiers in Tumour Progression}. 2010.
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