A common variation in the cannabinoid 1 receptor (CNR1) gene is
associated with pre-eclampsia in the Central European
population.

J 2011

A common variation in the cannabinoid 1 receptor (CNR1) gene is associated with pre-eclampsia in the Central European population.

BIENERTOVÁ VAŠKŮ, Julie; Petr BIENERT; Zuzana DOSTÁLOVÁ; Josef CHOVANEC; Anna VAŠKŮ et al.

Základní údaje

Originální název

A common variation in the cannabinoid 1 receptor (CNR1) gene is associated with pre-eclampsia in the Central European population.

Název česky

V populaci častý polymorfismus v genu pro endokanabionidní receptor 1 (CNR1) je asociován ve středoevropské populaci s preeklampsií

Autoři

BIENERTOVÁ VAŠKŮ, Julie; Petr BIENERT; Zuzana DOSTÁLOVÁ; Josef CHOVANEC; Anna VAŠKŮ a Vladimír VAŠKŮ

Vydání

European Journal of Obstetrics and Gynecology and Reproductive Biology, Amsterdam, Elsevier, 2011, 0301-2115

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

Genetika a molekulární biologie

Stát vydavatele

Nizozemské království

Utajení

není předmětem státního či obchodního tajemství

Impakt faktor

Impact factor: 1.974

Označené pro přenos do RIV

Ano

Kód RIV

RIV/00216224:14110/11:00081756

Organizační jednotka

Lékařská fakulta

DOI

https://doi.org/10.1016/j.ejogrb.2010.11.004

UT WoS

000288774600003

Klíčová slova česky

preeklapsie; endokanabionidní receptor 1; CNR1; polymorfismus

Klíčová slova anglicky

pre-eclampsia; endocannabinoid receptor 1; CNR1; SNP

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 1. 6. 2015 11:37, Soňa Böhmová

Anotace

ORIG CZ

V originále

OBJECTIVE: Recently it has been proposed that tightly regulated levels of endogenous cannabinoids play a fundamental role in early placental development. The aim of this study was to investigate associations of three single-nucleotide polymorphisms (SNPs) in the cannabinoid 1 receptor (CNR1) gene (rs1049353, rs12720071 and rs806368) and their inferred haplotypes with pre-eclampsia, a severe pregnancy-associated condition characterized by abnormal development and remodeling of spiral decidual arteries. STUDY DESIGN: The case-control study comprised a total of 115 pre-eclamptic women and 145 healthy pregnant controls, all originating from the Central-European Czech population. Using PCR-based methods, we tested rs1049353, rs12720071 and rs806368 in the CNR1 gene and haplotypes were constructed. RESULTS: Statistically significant difference in genotype distributions of rs806368, was observed when comparing the cases and the controls; the cases presenting with significantly lower proportion of CC homozygotes. In multivariate modeling, the rs806368 served as a predictor for pre-eclampsia development. Haplotype analysis revealed presence of four common haplotypes; the CAA haplotype being less frequent in pre-eclamptic cases compared to the controls. Analysis of regression models confirmed the independent prediction role of AAC haplotype for pre-eclampsia onset. CONCLUSION: This is the first study focusing on the relationship between SNPs in the CNR1 gene and pre-eclampsia risk. Although limited by a relatively small sample size, the study indicates that rs806368 in the CNR1 gene may act as a susceptibility marker for pre-eclampsia in humans.

Česky

Výsledky naší studia naznačují, že varianta rs806368 v genu pro CNR1 se může chovat jako modulátor vnímavosti vůči pre-eklampsii v české populaci.

Návaznosti

FRVS/881/2007, interní kód MU

Název: Mutační profil u pacientů s monogenní formou obezity

Investor: Ministerstvo školství, mládeže a tělovýchovy ČR, Mutační profil u pacientů s monogenní formou obezity

Citovat

BIENERTOVÁ VAŠKŮ, Julie; Petr BIENERT; Zuzana DOSTÁLOVÁ; Josef CHOVANEC; Anna VAŠKŮ a Vladimír VAŠKŮ. A common variation in the cannabinoid 1 receptor (CNR1) gene is associated with pre-eclampsia in the Central European population. European Journal of Obstetrics and Gynecology and Reproductive Biology. Amsterdam: Elsevier, 2011, roč. 155, č. 1, s. 19-22. ISSN 0301-2115. Dostupné z: https://doi.org/10.1016/j.ejogrb.2010.11.004.

@article{921484,
   author = {Bienertová Vašků, Julie and Bienert, Petr and Dostálová, Zuzana and Chovanec, Josef and Vašků, Anna and Vašků, Vladimír},
   article_location = {Amsterdam},
   article_number = {1},
   doi = {https://doi.org/10.1016/j.ejogrb.2010.11.004},
   keywords = {pre-eclampsia; endocannabinoid receptor 1; CNR1; SNP},
   language = {eng},
   issn = {0301-2115},
   journal = {European Journal of Obstetrics and Gynecology and Reproductive Biology},
   title = {A common variation in the cannabinoid 1 receptor (CNR1) gene is associated with pre-eclampsia in the Central European population.},
   volume = {155},
   year = {2011}
}

TY  - JOUR
ID  - 921484
AU  - Bienertová Vašků, Julie - Bienert, Petr - Dostálová, Zuzana - Chovanec, Josef - Vašků, Anna - Vašků, Vladimír
PY  - 2011
TI  - A common variation in the cannabinoid 1 receptor (CNR1) gene is associated with pre-eclampsia in the Central European population.
JF  - European Journal of Obstetrics and Gynecology and Reproductive Biology
VL  - 155
IS  - 1
SP  - 19-22
EP  - 19-22
PB  - Elsevier
SN  - 03012115
KW  - pre-eclampsia
KW  - endocannabinoid receptor 1
KW  - CNR1
KW  - SNP
N2  - OBJECTIVE: Recently it has been proposed that tightly regulated levels of endogenous cannabinoids play a fundamental role in early placental development. The aim of this study was to investigate associations of three single-nucleotide polymorphisms (SNPs) in the cannabinoid 1 receptor (CNR1) gene (rs1049353, rs12720071 and rs806368) and their inferred haplotypes with pre-eclampsia, a severe pregnancy-associated condition characterized by abnormal development and remodeling of spiral decidual arteries. STUDY DESIGN: The case-control study comprised a total of 115 pre-eclamptic women and 145 healthy pregnant controls, all originating from the Central-European Czech population. Using PCR-based methods, we tested rs1049353, rs12720071 and rs806368 in the CNR1 gene and haplotypes were constructed. RESULTS: Statistically significant difference in genotype distributions of rs806368, was observed when comparing the cases and the controls; the cases presenting with significantly lower proportion of CC homozygotes. In multivariate modeling, the rs806368 served as a predictor for pre-eclampsia development. Haplotype analysis revealed presence of four common haplotypes; the CAA haplotype being less frequent in pre-eclamptic cases compared to the controls. Analysis of regression models confirmed the independent prediction role of AAC haplotype for pre-eclampsia onset. CONCLUSION: This is the first study focusing on the relationship between SNPs in the CNR1 gene and pre-eclampsia risk. Although limited by a relatively small sample size, the study indicates that rs806368 in the CNR1 gene may act as a susceptibility marker for pre-eclampsia in humans.
ER  -

BIENERTOVÁ VAŠKŮ, Julie; Petr BIENERT; Zuzana DOSTÁLOVÁ; Josef CHOVANEC; Anna VAŠKŮ a Vladimír VAŠKŮ. A common variation in the cannabinoid 1 receptor (CNR1) gene is associated with pre-eclampsia in the Central European population. \textit{European Journal of Obstetrics and Gynecology and Reproductive Biology}. Amsterdam: Elsevier, 2011, roč.~155, č.~1, s.~19-22. ISSN~0301-2115. Dostupné z: https://doi.org/10.1016/j.ejogrb.2010.11.004.

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