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@article{921484,
author = {Bienertová Vašků, Julie and Bienert, Petr and Dostálová, Zuzana and Chovanec, Josef and Vašků, Anna and Vašků, Vladimír},
article_location = {Amsterdam},
article_number = {1},
doi = {http://dx.doi.org/10.1016/j.ejogrb.2010.11.004},
keywords = {pre-eclampsia; endocannabinoid receptor 1; CNR1; SNP},
language = {eng},
issn = {0301-2115},
journal = {European Journal of Obstetrics and Gynecology and Reproductive Biology},
title = {A common variation in the cannabinoid 1 receptor (CNR1) gene is associated with pre-eclampsia in the Central European population.},
volume = {155},
year = {2011}
}
TY - JOUR
ID - 921484
AU - Bienertová Vašků, Julie - Bienert, Petr - Dostálová, Zuzana - Chovanec, Josef - Vašků, Anna - Vašků, Vladimír
PY - 2011
TI - A common variation in the cannabinoid 1 receptor (CNR1) gene is associated with pre-eclampsia in the Central European population.
JF - European Journal of Obstetrics and Gynecology and Reproductive Biology
VL - 155
IS - 1
SP - 19-22
EP - 19-22
PB - Elsevier
SN - 03012115
KW - pre-eclampsia
KW - endocannabinoid receptor 1
KW - CNR1
KW - SNP
N2 - OBJECTIVE: Recently it has been proposed that tightly regulated levels of endogenous cannabinoids play a fundamental role in early placental development. The aim of this study was to investigate associations of three single-nucleotide polymorphisms (SNPs) in the cannabinoid 1 receptor (CNR1) gene (rs1049353, rs12720071 and rs806368) and their inferred haplotypes with pre-eclampsia, a severe pregnancy-associated condition characterized by abnormal development and remodeling of spiral decidual arteries. STUDY DESIGN: The case-control study comprised a total of 115 pre-eclamptic women and 145 healthy pregnant controls, all originating from the Central-European Czech population. Using PCR-based methods, we tested rs1049353, rs12720071 and rs806368 in the CNR1 gene and haplotypes were constructed. RESULTS: Statistically significant difference in genotype distributions of rs806368, was observed when comparing the cases and the controls; the cases presenting with significantly lower proportion of CC homozygotes. In multivariate modeling, the rs806368 served as a predictor for pre-eclampsia development. Haplotype analysis revealed presence of four common haplotypes; the CAA haplotype being less frequent in pre-eclamptic cases compared to the controls. Analysis of regression models confirmed the independent prediction role of AAC haplotype for pre-eclampsia onset. CONCLUSION: This is the first study focusing on the relationship between SNPs in the CNR1 gene and pre-eclampsia risk. Although limited by a relatively small sample size, the study indicates that rs806368 in the CNR1 gene may act as a susceptibility marker for pre-eclampsia in humans.
ER -
BIENERTOVÁ VAŠKŮ, Julie, Petr BIENERT, Zuzana DOSTÁLOVÁ, Josef CHOVANEC, Anna VAŠKŮ a Vladimír VAŠKŮ. A common variation in the cannabinoid 1 receptor (CNR1) gene is associated with pre-eclampsia in the Central European population. \textit{European Journal of Obstetrics and Gynecology and Reproductive Biology}. Amsterdam: Elsevier, 2011, roč.~155, č.~1, s.~19-22. ISSN~0301-2115. Dostupné z: https://dx.doi.org/10.1016/j.ejogrb.2010.11.004.
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