Difference in angiotensinogen haplotype frequences between
chronic heart failure and advanced atherosclerosis patients -
new prognostic factor?

J 2011

Difference in angiotensinogen haplotype frequences between chronic heart failure and advanced atherosclerosis patients - new prognostic factor?

PÁVKOVÁ GOLDBERGOVÁ, Monika; Lenka ŠPINAROVÁ; Jindřich ŠPINAR; Jiří PAŘENICA; Lenka ŠIŠKOVÁ et al.

Základní údaje

Originální název

Difference in angiotensinogen haplotype frequences between chronic heart failure and advanced atherosclerosis patients - new prognostic factor?

Autoři

PÁVKOVÁ GOLDBERGOVÁ, Monika; Lenka ŠPINAROVÁ; Jindřich ŠPINAR; Jiří PAŘENICA; Lenka ŠIŠKOVÁ; Ladislav GROCH; Jan MÁCHAL a Anna VAŠKŮ

Vydání

Physiological Research, Praha, Institute of Physiology, Academy of Sci. 2011, 0862-8408

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

Genetika a molekulární biologie

Stát vydavatele

Česká republika

Utajení

není předmětem státního či obchodního tajemství

Impakt faktor

Impact factor: 1.555

Označené pro přenos do RIV

Ano

Kód RIV

RIV/00216224:14110/11:00064823

Organizační jednotka

Lékařská fakulta

UT WoS

000288563800006

Klíčová slova anglicky

RAAS; heart failure; AGT

Příznaky

Mezinárodní význam

Změněno: 3. 10. 2012 13:57, Mgr. Michal Petr

Anotace

V originále

Numerous association studies have been involved in studying the angiotensinogen (AGT) variants, AGT plasma levels and relations to cardiovascular diseases, such as hypertension, myocardial infarction, coronary heart disease. To investigate a role of AGT G(-6)A and M235T genetic variants for chronic heart failure (CHF) and advanced atherosclerosis (AA), a total of 240 patients with CHF and 200 patients with AA of the Czech origin were evaluated for the study. The study shows the role of polymorphism AGT G(-6)A in genetic background among advanced atherosclerosis patients and chronic heart failure patients (Pg=0.001). This difference was observed also in comparison of AA patients with subgroup of CHF with dilated cardiomyopathy (Pg=0.02; Pa=0.009), and ischemic heart disease (Pg=0.007). The greatest difference between triple-vessel disease and chronic heart failure groups was observed in frequency of GT haplotype (P<0.001) and GGMT associated genotype (P<0.001). Retrospectively, when the subgroups of CHF were compared to AA group (AA vs. IHD with CHF - P < 0.001; and AA vs. DCM - P<0.001) we found the same trend. These results suggest AGT genetic variants as a risk factor for chronic heart failure compared to advanced atherosclerosis disease without heart failure, with a strong difference between IHD patients and chronic heart failure patients with ischemic heart disease, especially in haplotypes and associated genotypes.

Návaznosti

NR9356, projekt VaV

Název: Komplexní zhodnocení vlivu polymorfismu matrix metalloproteináz-1,2,3,9, tkáńového inhibitoru matrix metaloproteináz-1 a ACE na remodelaci levé komory a střednědobou prognózu po akutním infarktu mykardu s ST elevacemi léčeném primární PCI

Investor: Ministerstvo zdravotnictví ČR, Komplexní zhodnocení vlivu polymorfismu matrix metalloproteináz-1,2,3,9, tkáńového inhibitoru matrix metaloproteináz-1 a ACE na remodelaci levé komory a střednědobou prognózu po akutním infarktu mykardu s ST elevacemi léčeném primární PCI

Citovat

PÁVKOVÁ GOLDBERGOVÁ, Monika; Lenka ŠPINAROVÁ; Jindřich ŠPINAR; Jiří PAŘENICA; Lenka ŠIŠKOVÁ; Ladislav GROCH; Jan MÁCHAL a Anna VAŠKŮ. Difference in angiotensinogen haplotype frequences between chronic heart failure and advanced atherosclerosis patients - new prognostic factor? Physiological Research. Praha: Institute of Physiology, Academy of Sci., 2011, roč. 60, č. 1, s. 55-64. ISSN 0862-8408.

@article{921485,
   author = {Pávková Goldbergová, Monika and Špinarová, Lenka and Špinar, Jindřich and Pařenica, Jiří and Šišková, Lenka and Groch, Ladislav and Máchal, Jan and Vašků, Anna},
   article_location = {Praha},
   article_number = {1},
   keywords = {RAAS; heart failure; AGT},
   language = {eng},
   issn = {0862-8408},
   journal = {Physiological Research},
   title = {Difference in angiotensinogen haplotype frequences between chronic heart failure and advanced atherosclerosis patients - new prognostic factor?},
   volume = {60},
   year = {2011}
}

TY  - JOUR
ID  - 921485
AU  - Pávková Goldbergová, Monika - Špinarová, Lenka - Špinar, Jindřich - Pařenica, Jiří - Šišková, Lenka - Groch, Ladislav - Máchal, Jan - Vašků, Anna
PY  - 2011
TI  - Difference in angiotensinogen haplotype frequences between chronic heart failure and advanced atherosclerosis patients - new prognostic factor?
JF  - Physiological Research
VL  - 60
IS  - 1
SP  - 55-64
EP  - 55-64
PB  - Institute of Physiology, Academy of Sci.
SN  - 08628408
KW  - RAAS
KW  - heart failure
KW  - AGT
N2  - Numerous association studies have been involved in studying the angiotensinogen (AGT) variants, AGT plasma levels and relations to cardiovascular diseases, such as hypertension, myocardial infarction, coronary heart disease. To investigate a role of AGT G(-6)A and M235T genetic variants for chronic heart failure (CHF) and advanced atherosclerosis (AA), a total of 240 patients with CHF and 200 patients with AA of the Czech origin were evaluated for the study. The study shows the role of polymorphism AGT G(-6)A in genetic background among advanced atherosclerosis patients and chronic heart failure patients (Pg=0.001). This difference was observed also in comparison of AA patients with subgroup of CHF with dilated cardiomyopathy (Pg=0.02; Pa=0.009), and ischemic heart disease (Pg=0.007). The greatest difference between triple-vessel disease and chronic heart failure groups was observed in frequency of GT haplotype (P<0.001) and GGMT associated genotype (P<0.001). Retrospectively, when the subgroups of CHF were compared to AA group (AA vs. IHD with CHF - P < 0.001; and AA vs. DCM - P<0.001) we found the same trend. These results suggest AGT genetic variants as a risk factor for chronic heart failure compared to advanced atherosclerosis disease without heart failure, with a strong difference between IHD patients and chronic heart failure patients with ischemic heart disease, especially in haplotypes and associated genotypes.
ER  -

PÁVKOVÁ GOLDBERGOVÁ, Monika; Lenka ŠPINAROVÁ; Jindřich ŠPINAR; Jiří PAŘENICA; Lenka ŠIŠKOVÁ; Ladislav GROCH; Jan MÁCHAL a Anna VAŠKŮ. Difference in angiotensinogen haplotype frequences between chronic heart failure and advanced atherosclerosis patients - new prognostic factor? \textit{Physiological Research}. Praha: Institute of Physiology, Academy of Sci., 2011, roč.~60, č.~1, s.~55-64. ISSN~0862-8408.

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