| KŘEN, Leoš, Ondřej SLABÝ, Katarína MÚČKOVÁ, Eva LŽIČAŘOVÁ, Marek SOVA, Václav VYBÍHAL, Tomáš SVOBODA, Pavel FADRUS, Radek LAKOMÝ, Petr VAŇHARA, Zdenka KŘENOVÁ, Jaroslav ŠTĚRBA, Martin SMRČKA a Jaroslav MICHÁLEK. Expression of immune-modulatory molecules HLA-G and HLA-E by tumor cells in glioblastomas: An unexpected prognostic significance?. Online. Neuropathology. 2011, roč. 31, č. 2, s. 129-134. ISSN 0919-6544. Dostupné z: https://dx.doi.org/10.1111/j.1440-1789.2010.01149.x. [citováno 2024-04-24] |
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@article{921912,
author = {Křen, Leoš and Slabý, Ondřej and Múčková, Katarína and Lžičařová, Eva and Sova, Marek and Vybíhal, Václav and Svoboda, Tomáš and Fadrus, Pavel and Lakomý, Radek and Vaňhara, Petr and Křenová, Zdenka and Štěrba, Jaroslav and Smrčka, Martin and Michálek, Jaroslav},
article_number = {2},
doi = {http://dx.doi.org/10.1111/j.1440-1789.2010.01149.x},
keywords = {glioblastoma; HLA-E; HLA-G; survival},
language = {eng},
issn = {0919-6544},
journal = {Neuropathology},
title = {Expression of immune-modulatory molecules HLA-G and HLA-E by tumor cells in glioblastomas: An unexpected prognostic significance?},
volume = {31},
year = {2011}
}
TY - JOUR
ID - 921912
AU - Křen, Leoš - Slabý, Ondřej - Múčková, Katarína - Lžičařová, Eva - Sova, Marek - Vybíhal, Václav - Svoboda, Tomáš - Fadrus, Pavel - Lakomý, Radek - Vaňhara, Petr - Křenová, Zdenka - Štěrba, Jaroslav - Smrčka, Martin - Michálek, Jaroslav
PY - 2011
TI - Expression of immune-modulatory molecules HLA-G and HLA-E by tumor cells in glioblastomas: An unexpected prognostic significance?
JF - Neuropathology
VL - 31
IS - 2
SP - 129-134
EP - 129-134
SN - 09196544
KW - glioblastoma
KW - HLA-E
KW - HLA-G
KW - survival
N2 - The role of nonclassical human leukocyte antigens G and E (HLA-G and HLA-E) was originally thought to be restricted to the protection of the fetus from a maternal allorecognition. Now it is known that HLA-G and HLA-E exert multiple immunoregulatory functions. A prognostic significance of the expression of HLA-G and HLA-E by neoplastic cells in glioblastoma is not well characterized. In this study, we evaluated the expression of HLA-G and HLA-E by neoplastic cells in 39 cases of glioblastoma. We found the production of HLA-G and HLA in a majority of cases. There was an unexpected positive correlation between the expression of HLA-E and length of survival. We speculate that the expression of this molecule by neoplastic cells may represent a coincidental selective pro-host advantage related to better response to subsequent therapeutic modalities. Mechanisms of glioblastoma cell pathophysiology and mechanisms of responses to therapeutic interventions in respect to the expression of these molecules deserves further study.
ER -
KŘEN, Leoš, Ondřej SLABÝ, Katarína MÚČKOVÁ, Eva LŽIČAŘOVÁ, Marek SOVA, Václav VYBÍHAL, Tomáš SVOBODA, Pavel FADRUS, Radek LAKOMÝ, Petr VAŇHARA, Zdenka KŘENOVÁ, Jaroslav ŠTĚRBA, Martin SMRČKA a Jaroslav MICHÁLEK. Expression of immune-modulatory molecules HLA-G and HLA-E by tumor cells in glioblastomas: An unexpected prognostic significance?. Online. \textit{Neuropathology}. 2011, roč.~31, č.~2, s.~129-134. ISSN~0919-6544. Dostupné z: https://dx.doi.org/10.1111/j.1440-1789.2010.01149.x. [citováno 2024-04-24]
|
