Relationship of resistin levels with endometrial cancer risk

J 2011

Relationship of resistin levels with endometrial cancer risk

HLAVNA, Marián; Lukáš KOHÚT; Jolana LIPKOVÁ; Julie BIENERTOVÁ VAŠKŮ; Zuzana DOSTÁLOVÁ et al.

Základní údaje

Originální název

Relationship of resistin levels with endometrial cancer risk

Autoři

HLAVNA, Marián; Lukáš KOHÚT; Jolana LIPKOVÁ ; Julie BIENERTOVÁ VAŠKŮ; Zuzana DOSTÁLOVÁ; Josef CHOVANEC a Anna VAŠKŮ

Vydání

Neoplasma, 2011, 0028-2685

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30200 3.2 Clinical medicine

Stát vydavatele

Slovensko

Utajení

není předmětem státního či obchodního tajemství

Impakt faktor

Impact factor: 1.440

Označené pro přenos do RIV

Ano

Kód RIV

RIV/00216224:14110/11:00051781

Organizační jednotka

Lékařská fakulta

DOI

https://doi.org/10.4149/neo_2011_02_124

UT WoS

000290695700005

Klíčová slova anglicky

Endometrial cancer; resistin; SNP

Příznaky

Mezinárodní význam

Změněno: 13. 4. 2012 11:40, Mgr. Michal Petr

Anotace

V originále

Cancer of endometrium (CAE) is the most common gynecologic malignancy in industrialized nations. Increased resistin levels, an adipocytokine produced by adipose tissue and macrophages, have been considered as a risk factor in gastric, colon and breast cancer, recently. No studies associating resistin levels with endometrial cancer have been done so far. The purpose of this case-control study was to determine the relationship between serum circulating resistin levels and resistin gene -420C>G (rs3219175) variant in endometrial cancer patients. 37 Caucasian female patients and 39 healthy controls were enrolled in this study. Difference in resistin levels between age and BMI matched patients group (mean 24.2 ng/ml) and control subjects (mean 10.1 ng/ml) were statistically significant (p G (rs3219175) within resistin gene and no significant association between resistin levels and investigated polymorphism was found. Furthermore, no significant association between higher resistin levels and diabetes mellitus 2, body mass index, smoking or age have been observed within studied groups. To our knowledge, this is the first study examining the relationship between serum resistin levels and endometrial cancer and our results show, that patients with endometrial cancer have significantly increased circulating levels of resistin compared to control subjects.

Citovat

HLAVNA, Marián; Lukáš KOHÚT; Jolana LIPKOVÁ; Julie BIENERTOVÁ VAŠKŮ; Zuzana DOSTÁLOVÁ; Josef CHOVANEC a Anna VAŠKŮ. Relationship of resistin levels with endometrial cancer risk. Neoplasma. 2011, roč. 58, č. 2, s. 124-128. ISSN 0028-2685. Dostupné z: https://doi.org/10.4149/neo_2011_02_124.

@article{922793,
   author = {Hlavna, Marián and Kohút, Lukáš and Lipková, Jolana and Bienertová Vašků, Julie and Dostálová, Zuzana and Chovanec, Josef and Vašků, Anna},
   article_number = {2},
   doi = {https://doi.org/10.4149/neo_2011_02_124},
   keywords = {Endometrial cancer; resistin; SNP},
   language = {eng},
   issn = {0028-2685},
   journal = {Neoplasma},
   title = {Relationship of resistin levels with endometrial cancer risk},
   volume = {58},
   year = {2011}
}

TY  - JOUR
ID  - 922793
AU  - Hlavna, Marián - Kohút, Lukáš - Lipková, Jolana - Bienertová Vašků, Julie - Dostálová, Zuzana - Chovanec, Josef - Vašků, Anna
PY  - 2011
TI  - Relationship of resistin levels with endometrial cancer risk
JF  - Neoplasma
VL  - 58
IS  - 2
SP  - 124-128
EP  - 124-128
SN  - 00282685
KW  - Endometrial cancer
KW  - resistin
KW  - SNP
N2  - Cancer of endometrium (CAE) is the most common gynecologic malignancy in industrialized nations. Increased resistin levels, an adipocytokine produced by adipose tissue and macrophages, have been considered as a risk factor in gastric, colon and breast cancer, recently. No studies associating resistin levels with endometrial cancer have been done so far. The purpose of this case-control study was to determine the relationship between serum circulating resistin levels and resistin gene -420C>G (rs3219175) variant in endometrial cancer patients. 37 Caucasian female patients and 39 healthy controls were enrolled in this study. Difference in resistin levels between age and BMI matched patients group (mean 24.2 ng/ml) and control subjects (mean 10.1 ng/ml) were statistically significant (p G (rs3219175) within resistin gene and no significant association between resistin levels and investigated polymorphism was found. Furthermore, no significant association between higher resistin levels and diabetes mellitus 2, body mass index, smoking or age have been observed within studied groups. To our knowledge, this is the first study examining the relationship between serum resistin levels and endometrial cancer and our results show, that patients with endometrial cancer have significantly increased circulating levels of resistin compared to control subjects.
ER  -

HLAVNA, Marián; Lukáš KOHÚT; Jolana LIPKOVÁ; Julie BIENERTOVÁ VAŠKŮ; Zuzana DOSTÁLOVÁ; Josef CHOVANEC a Anna VAŠKŮ. Relationship of resistin levels with endometrial cancer risk. \textit{Neoplasma}. 2011, roč.~58, č.~2, s.~124-128. ISSN~0028-2685. Dostupné z: https://doi.org/10.4149/neo\_{}2011\_{}02\_{}124.

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