| BENEŠ, Petr, Lucia KNOPFOVÁ, Filip TRČKA, Alice NEMAJEROVÁ, Diana PINHEIRO, Karel SOUČEK, Miroslav FOJTA a Jan ŠMARDA. Inhibition of topoisomerase IIa: Novel function of wedelolactone. Cancer Letters. ELSEVIER, 2011, roč. 303, č. 1, s. 29-38. ISSN 0304-3835. Dostupné z: https://dx.doi.org/10.1016/j.canlet.2011.01.002. |
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@article{927376,
author = {Beneš, Petr and Knopfová, Lucia and Trčka, Filip and Nemajerová, Alice and Pinheiro, Diana and Souček, Karel and Fojta, Miroslav and Šmarda, Jan},
article_number = {1},
doi = {http://dx.doi.org/10.1016/j.canlet.2011.01.002},
keywords = {Apoptosis; DNA damage; Proliferation; Topoisomerase; Wedelolactone},
language = {eng},
issn = {0304-3835},
journal = {Cancer Letters},
title = {Inhibition of topoisomerase IIa: Novel function of wedelolactone},
url = {http://www.sciencedirect.com/science/article/pii/S0304383511000127},
volume = {303},
year = {2011}
}
TY - JOUR
ID - 927376
AU - Beneš, Petr - Knopfová, Lucia - Trčka, Filip - Nemajerová, Alice - Pinheiro, Diana - Souček, Karel - Fojta, Miroslav - Šmarda, Jan
PY - 2011
TI - Inhibition of topoisomerase IIa: Novel function of wedelolactone
JF - Cancer Letters
VL - 303
IS - 1
SP - 29-38
EP - 29-38
PB - ELSEVIER
SN - 03043835
KW - Apoptosis
KW - DNA damage
KW - Proliferation
KW - Topoisomerase
KW - Wedelolactone
UR - http://www.sciencedirect.com/science/article/pii/S0304383511000127
L2 - http://www.sciencedirect.com/science/article/pii/S0304383511000127
N2 - The naturally occurring coumestan wedelolactone has been previously shown to reduce growth of various cancer cells. So far, the growth-suppressing effect of wedelolactone has been attributed to the inhibition of the NFkB transcription factor and/or androgen receptors. We found that wedelolactone suppressed growth and induced apoptosis of androgen receptor-negative MDA-MB-231 breast cancer cells at concentrations that did not inhibit the NFkB activity. The cells responded to wedelolactone by the S and G2/M phase cell cycle arrest and induction of the DNA damage signaling. Wedelolactone interacted with dsDNA and inhibited the activity of DNA topoisomerase IIa. We conclude that wedelolactone can act as growth suppressor independently of NFkB and androgen receptors.
ER -
BENEŠ, Petr, Lucia KNOPFOVÁ, Filip TRČKA, Alice NEMAJEROVÁ, Diana PINHEIRO, Karel SOUČEK, Miroslav FOJTA a Jan ŠMARDA. Inhibition of topoisomerase IIa: Novel function of wedelolactone. \textit{Cancer Letters}. ELSEVIER, 2011, roč.~303, č.~1, s.~29-38. ISSN~0304-3835. Dostupné z: https://dx.doi.org/10.1016/j.canlet.2011.01.002.
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