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@proceedings{944477,
author = {Melounová, Jitka and Matejovičová, Milena and Králíková, Michaela and Žáková, Jana and Crha, Igor},
booktitle = {8th International Conference on Homocysteine Metabolism},
keywords = {homocysteine, DNA damage, sperm, comet assay},
title = {The Effect of Homocysteine on Sperm DNA Integrity},
year = {2011}
}
TY - CONF
ID - 944477
AU - Melounová, Jitka - Matejovičová, Milena - Králíková, Michaela - Žáková, Jana - Crha, Igor
PY - 2011
TI - The Effect of Homocysteine on Sperm DNA Integrity
KW - homocysteine, DNA damage, sperm, comet assay
N2 - Physiological autooxidation of homocysteine (Hcy) generates reactive oxygen species (ROS) which participate in 30-80% cases of mens infertility. Besides the beneficial effects of ROS, such as activation of spermatozoa during fertilization or stimulation of acrosome reaction, ROS directly damage the sperm DNA. The aim of this study was to find out if the increased concentrations of homocysteine in ejaculate affect the DNA integrity in sperms. Conclusion: Homocysteine added to the ejaculate slightly increased the level of basal DNA damage.
ER -
MELOUNOVÁ, Jitka, Milena MATEJOVIČOVÁ, Michaela KRÁLÍKOVÁ, Jana ŽÁKOVÁ a Igor CRHA. The Effect of Homocysteine on Sperm DNA Integrity. In \textit{8th International Conference on Homocysteine Metabolism}. 2011.
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