Intraindividual variability of homocysteine and related thiols 
concentrations in follicular fluid

J 2011

Intraindividual variability of homocysteine and related thiols concentrations in follicular fluid

KRÁLÍKOVÁ, Michaela, Jitka MELOUNOVÁ, Igor CRHA, Milena MATEJOVIČOVÁ, Jana ŽÁKOVÁ et. al.

Základní údaje

Originální název

Intraindividual variability of homocysteine and related thiols concentrations in follicular fluid

Autoři

KRÁLÍKOVÁ, Michaela (203 Česká republika, garant, domácí), Jitka MELOUNOVÁ (203 Česká republika, domácí), Igor CRHA (203 Česká republika, domácí), Milena MATEJOVIČOVÁ (203 Česká republika, domácí), Jana ŽÁKOVÁ (203 Česká republika, domácí), Jiří JARKOVSKÝ (203 Česká republika, domácí) a Jaroslava TALLOVÁ (203 Česká republika, domácí)

Vydání

Journal of Assisted Reproduction and Genetics, 2011, 1058-0468

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30214 Obstetrics and gynaecology

Stát vydavatele

Německo

Utajení

není předmětem státního či obchodního tajemství

Impakt faktor

Impact factor: 1.844

Kód RIV

RIV/00216224:14110/11:00056980

Organizační jednotka

Lékařská fakulta

DOI

http://dx.doi.org/10.1007/s10815-011-9606-9

UT WoS

000294808400014

Klíčová slova anglicky

Homocysteine; Thiols; Follicular fluid; Oocytes

Příznaky

Mezinárodní význam

Změněno: 12. 4. 2012 07:34, Mgr. Michal Petr

Anotace

V originále

To determine intraindividual variability in concentrations of homocysteine and related thiols in follicular fluids of particular follicles after ovarian stimulation and assess the differences between follicles with/or without oocytes. Methods HPLC-FD analysis of plasma and follicular fluid cysteine, homocysteine, cysteinylglycine and glutathione in women undergoing IVF. In blood plasma, the homocysteine, cysteine, and cysteinylglycine concentrations decreased significantly during stimulation with rec FSH (p<0.001). We found significant differences in concentrations of cysteine and glutathione between follicles with or without retrieved oocytes. High intraindividual variability in concentrations of thiols was determined. The concentration variability of thiols between single follicles is very high and we recommend mean at least from 3 follicles with/or without oocytes for characterization of each woman. It is the best to examine individual follicles for further research and analysis of fertility outcomes.

Návaznosti

NS9661, projekt VaV

Název: Vliv metabolismu homocysteinu na poruchy plodnosti.

Investor: Ministerstvo zdravotnictví ČR, Vliv metabolismu homocysteinu na poruchy plodnosti

Citovat

KRÁLÍKOVÁ, Michaela, Jitka MELOUNOVÁ, Igor CRHA, Milena MATEJOVIČOVÁ, Jana ŽÁKOVÁ, Jiří JARKOVSKÝ a Jaroslava TALLOVÁ. Intraindividual variability of homocysteine and related thiols concentrations in follicular fluid. Journal of Assisted Reproduction and Genetics. 2011, roč. 28, č. 9, s. 863-868. ISSN 1058-0468. Dostupné z: https://dx.doi.org/10.1007/s10815-011-9606-9.

@article{950054,
   author = {Králíková, Michaela and Melounová, Jitka and Crha, Igor and Matejovičová, Milena and Žáková, Jana and Jarkovský, Jiří and Tallová, Jaroslava},
   article_number = {9},
   doi = {http://dx.doi.org/10.1007/s10815-011-9606-9},
   keywords = {Homocysteine; Thiols; Follicular fluid; Oocytes},
   language = {eng},
   issn = {1058-0468},
   journal = {Journal of Assisted Reproduction and Genetics},
   title = {Intraindividual variability of homocysteine and related thiols concentrations in follicular fluid},
   volume = {28},
   year = {2011}
}

TY  - JOUR
ID  - 950054
AU  - Králíková, Michaela - Melounová, Jitka - Crha, Igor - Matejovičová, Milena - Žáková, Jana - Jarkovský, Jiří - Tallová, Jaroslava
PY  - 2011
TI  - Intraindividual variability of homocysteine and related thiols concentrations in follicular fluid
JF  - Journal of Assisted Reproduction and Genetics
VL  - 28
IS  - 9
SP  - 863-868
EP  - 863-868
SN  - 10580468
KW  - Homocysteine
KW  - Thiols
KW  - Follicular fluid
KW  - Oocytes
N2  - To determine intraindividual variability in concentrations of homocysteine and related thiols in follicular fluids of particular follicles after ovarian stimulation and assess the differences between follicles with/or without oocytes. Methods HPLC-FD analysis of plasma and follicular fluid cysteine, homocysteine, cysteinylglycine and glutathione in women undergoing IVF. In blood plasma, the homocysteine, cysteine, and cysteinylglycine concentrations decreased significantly during stimulation with rec FSH (p<0.001). We found significant differences in concentrations of cysteine and glutathione between follicles with or without retrieved oocytes. High intraindividual variability in concentrations of thiols was determined. The concentration variability of thiols between single follicles is very high and we recommend mean at least from 3 follicles with/or without oocytes for characterization of each woman. It is the best to examine individual follicles for further research and analysis of fertility outcomes.
ER  -

KRÁLÍKOVÁ, Michaela, Jitka MELOUNOVÁ, Igor CRHA, Milena MATEJOVIČOVÁ, Jana ŽÁKOVÁ, Jiří JARKOVSKÝ a Jaroslava TALLOVÁ. Intraindividual variability of homocysteine and related thiols concentrations in follicular fluid. \textit{Journal of Assisted Reproduction and Genetics}. 2011, roč.~28, č.~9, s.~863-868. ISSN~1058-0468. Dostupné z: https://dx.doi.org/10.1007/s10815-011-9606-9.

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