| KNOPFOVÁ, Lucia, Petr BENEŠ, Lucie PEKARČÍKOVÁ, Markéta HERMANOVÁ, Michal MASAŘÍK, Karel SOUČEK a Jan ŠMARDA. c-Myb regulates MMP1, MMP9 and cathepsin D: Implications for the matrix-dependent breast cancer cell invasion and metastasis. In Zing Cancer Conference. 2011. |
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@proceedings{958778,
author = {Knopfová, Lucia and Beneš, Petr and Pekarčíková, Lucie and Hermanová, Markéta and Masařík, Michal and Souček, Karel and Šmarda, Jan},
booktitle = {Zing Cancer Conference},
keywords = {c-Myb; breast cancer; cell invasion; metastasis},
language = {eng},
title = {c-Myb regulates MMP1, MMP9 and cathepsin D: Implications for the matrix-dependent breast cancer cell invasion and metastasis},
year = {2011}
}
TY - CONF
ID - 958778
AU - Knopfová, Lucia - Beneš, Petr - Pekarčíková, Lucie - Hermanová, Markéta - Masařík, Michal - Souček, Karel - Šmarda, Jan
PY - 2011
TI - c-Myb regulates MMP1, MMP9 and cathepsin D: Implications for the matrix-dependent breast cancer cell invasion and metastasis
KW - c-Myb
KW - breast cancer
KW - cell invasion
KW - metastasis
N2 - Ectopically expressed c-Myb enhanced motility and ability of human MDA-MB-231 and mouse 4T1 mammary cancer cells to invade Matrigel but not the collagen I matrix in vitro. c-Myb strongly increased expression/activity of cathepsin D and matrix metalloproteinase (MMP) 9 and significantly down-regulated MMP1. The gene coding for cathepsin D was identified as direct c-Myb-target gene and downstream effector of the c-Myb migration-promoting function. Finally, we demonstrated that c-Myb delayed growth of mammary tumors in BALB/c mice and affected metastatic potential of breast cancer cells in an organ-specific manner. This study demonstrates potential role of a stromal context for the c-Myb function in control of breast cancer invasion and metastasis.
ER -
KNOPFOVÁ, Lucia, Petr BENEŠ, Lucie PEKARČÍKOVÁ, Markéta HERMANOVÁ, Michal MASAŘÍK, Karel SOUČEK a Jan ŠMARDA. c-Myb regulates MMP1, MMP9 and cathepsin D: Implications for the matrix-dependent breast cancer cell invasion and metastasis. In \textit{Zing Cancer Conference}. 2011.
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