Changes in the expression of FGFR3 in patients with chronic
myeloid leukaemia receiving transplants of allogeneic
peripheral blood stem cells

J 2001

Changes in the expression of FGFR3 in patients with chronic myeloid leukaemia receiving transplants of allogeneic peripheral blood stem cells

DVORAKOVA, D., Pavel KREJČÍ, Jiří MAYER, Jiří FAJKUS, Aleš HAMPL et. al.

Základní údaje

Originální název

Changes in the expression of FGFR3 in patients with chronic myeloid leukaemia receiving transplants of allogeneic peripheral blood stem cells

Autoři

DVORAKOVA, D., Pavel KREJČÍ, Jiří MAYER, Jiří FAJKUS, Aleš HAMPL a Petr DVOŘÁK

Vydání

British journal of haematology, England, Wiley-Blackwell, 2001, 0007-1048

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30105 Physiology

Stát vydavatele

Velká Británie a Severní Irsko

Utajení

není předmětem státního či obchodního tajemství

Impakt faktor

Impact factor: 2.815

Organizační jednotka

Přírodovědecká fakulta

DOI

http://dx.doi.org/10.1046/j.1365-2141.2001.02829.x

UT WoS

000169428600040

Klíčová slova anglicky

fibroblast growth factor receptor 3; chronic myeloid leukaemia; stem cell transplantation; BCR/ABL; prognosis

Změněno: 15. 2. 2012 16:45, Mgr. Jiřina Medalová, Ph.D.

Anotace

V originále

Fibroblast growth factor receptors (FGFR1-4) are implicated in various cellular events, including cell growth and transformation. Here, we showed that patients suffering from chronic myeloid leukaemia (CML) express high levels of FGFR3 mRNA in white blood cells (WBCs). After stem cell transplantation and reconstitution of haematopoiesis, the expression of FGFR3 decreased and was maintained at low levels that are typical of healthy individuals. However, FGFR3 expression became upregulated again in those patients that had accelerated BCR/ABL rearrangement and underwent relapse of leukaemia. Our findings suggest that. in CML, the changing levels of FGFR3 transcripts in WBCs map have prognostic significance.

Citovat

DVORAKOVA, D., Pavel KREJČÍ, Jiří MAYER, Jiří FAJKUS, Aleš HAMPL a Petr DVOŘÁK. Changes in the expression of FGFR3 in patients with chronic myeloid leukaemia receiving transplants of allogeneic peripheral blood stem cells. British journal of haematology. England: Wiley-Blackwell, 2001, roč. 113, č. 3, s. 832-835. ISSN 0007-1048. Dostupné z: https://dx.doi.org/10.1046/j.1365-2141.2001.02829.x.

@article{971689,
   author = {Dvorakova, D. and Krejčí, Pavel and Mayer, Jiří and Fajkus, Jiří and Hampl, Aleš and Dvořák, Petr},
   article_location = {England},
   article_number = {3},
   doi = {http://dx.doi.org/10.1046/j.1365-2141.2001.02829.x},
   keywords = {fibroblast growth factor receptor 3; chronic myeloid leukaemia; stem cell transplantation; BCR/ABL; prognosis},
   language = {eng},
   issn = {0007-1048},
   journal = {British journal of haematology},
   title = {Changes in the expression of FGFR3 in patients with chronic myeloid leukaemia receiving transplants of allogeneic peripheral blood stem cells},
   volume = {113},
   year = {2001}
}

TY  - JOUR
ID  - 971689
AU  - Dvorakova, D. - Krejčí, Pavel - Mayer, Jiří - Fajkus, Jiří - Hampl, Aleš - Dvořák, Petr
PY  - 2001
TI  - Changes in the expression of FGFR3 in patients with chronic myeloid leukaemia receiving transplants of allogeneic peripheral blood stem cells
JF  - British journal of haematology
VL  - 113
IS  - 3
SP  - 832-835
EP  - 832-835
PB  - Wiley-Blackwell
SN  - 00071048
KW  - fibroblast growth factor receptor 3
KW  - chronic myeloid leukaemia
KW  - stem cell transplantation
KW  - BCR/ABL
KW  - prognosis
N2  - Fibroblast growth factor receptors (FGFR1-4) are implicated in various cellular events, including cell growth and transformation. Here, we showed that patients suffering from chronic myeloid leukaemia (CML) express high levels of FGFR3 mRNA in white blood cells (WBCs). After stem cell transplantation and reconstitution of haematopoiesis, the expression of FGFR3 decreased and was maintained at low levels that are typical of healthy individuals. However, FGFR3 expression became upregulated again in those patients that had accelerated BCR/ABL rearrangement and underwent relapse of leukaemia. Our findings suggest that. in CML, the changing levels of FGFR3 transcripts in WBCs map have prognostic significance.
ER  -

DVORAKOVA, D., Pavel KREJČÍ, Jiří MAYER, Jiří FAJKUS, Aleš HAMPL a Petr DVOŘÁK. Changes in the expression of FGFR3 in patients with chronic myeloid leukaemia receiving transplants of allogeneic peripheral blood stem cells. \textit{British journal of haematology}. England: Wiley-Blackwell, 2001, roč.~113, č.~3, s.~832-835. ISSN~0007-1048. Dostupné z: https://dx.doi.org/10.1046/j.1365-2141.2001.02829.x.

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