| KŘEN, Leoš, Pavel FABIAN, Ondřej SLABÝ, Andrea JANÍKOVÁ, Ondřej SOUČEK, Jaroslav ŠTĚRBA, Zdenka KŘENOVÁ, Jaroslav MICHÁLEK a Zdeněk KRÁL. Multifunctional immune-modulatory protein HLA-E identified in classical Hodgkin lymphoma: Possible implications. Pathology Research and Practice. Jena, Germany: Elsevier GmbH, 2012, roč. 208, č. 1, s. 45-49. ISSN 0344-0338. Dostupné z: https://dx.doi.org/10.1016/j.prp.2011.11.004. |
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@article{984247,
author = {Křen, Leoš and Fabian, Pavel and Slabý, Ondřej and Janíková, Andrea and Souček, Ondřej and Štěrba, Jaroslav and Křenová, Zdenka and Michálek, Jaroslav and Král, Zdeněk},
article_location = {Jena, Germany},
article_number = {1},
doi = {http://dx.doi.org/10.1016/j.prp.2011.11.004},
keywords = {HLA-E; Hodgkin lymphoma; Microenvironment; Clinical stage},
language = {eng},
issn = {0344-0338},
journal = {Pathology Research and Practice},
title = {Multifunctional immune-modulatory protein HLA-E identified in classical Hodgkin lymphoma: Possible implications},
url = {http://www.ncbi.nlm.nih.gov/pubmed/22177730},
volume = {208},
year = {2012}
}
TY - JOUR
ID - 984247
AU - Křen, Leoš - Fabian, Pavel - Slabý, Ondřej - Janíková, Andrea - Souček, Ondřej - Štěrba, Jaroslav - Křenová, Zdenka - Michálek, Jaroslav - Král, Zdeněk
PY - 2012
TI - Multifunctional immune-modulatory protein HLA-E identified in classical Hodgkin lymphoma: Possible implications
JF - Pathology Research and Practice
VL - 208
IS - 1
SP - 45-49
EP - 45-49
PB - Elsevier GmbH
SN - 03440338
KW - HLA-E
KW - Hodgkin lymphoma
KW - Microenvironment
KW - Clinical stage
UR - http://www.ncbi.nlm.nih.gov/pubmed/22177730
L2 - http://www.ncbi.nlm.nih.gov/pubmed/22177730
N2 - Although the role of the non-classical human leukocyte antigen E (HLA-E) was originally thought to be limited to the development of a maternal tolerance to a semiallogeneic fetal graft, it is now known that HLA-E exerts multiple immunoregulatory functions. The significance of the presence of HLA-E in neoplastic cells and/or backround microenvironment cells in classical Hodgkin lymphoma (cHL) is not well characterized. In our study, we evaluated the presence of HLA-E in both neoplastic and background cells in 40 cases of cHL. We found HLA-E in both neoplastic and background cells. There was a positive statistical correlation between the expression of HLA-E in neoplastic cells and the clinical stage of the disease, which indicates an immune-tolerogenic property of this multiple-purpose molecule. The presence of HLA-E in background cells seems to be prognostically neutral but its significance still needs to be determined. The mechanisms regulating the immunopathology of cHL neoplastic cells with respect to the presence of these molecule deserve further studies.
ER -
KŘEN, Leoš, Pavel FABIAN, Ondřej SLABÝ, Andrea JANÍKOVÁ, Ondřej SOUČEK, Jaroslav ŠTĚRBA, Zdenka KŘENOVÁ, Jaroslav MICHÁLEK a Zdeněk KRÁL. Multifunctional immune-modulatory protein HLA-E identified in classical Hodgkin lymphoma: Possible implications. \textit{Pathology Research and Practice}. Jena, Germany: Elsevier GmbH, 2012, roč.~208, č.~1, s.~45-49. ISSN~0344-0338. Dostupné z: https://dx.doi.org/10.1016/j.prp.2011.11.004.
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