Flow Based Enumeration of Plasmablasts in Peripheral Blood
After Vaccination as a Novel Diagnostic Marker for Assessing
Antibody Responses in Patients with Hypogammaglobulinaemia

C 2012

Flow Based Enumeration of Plasmablasts in Peripheral Blood After Vaccination as a Novel Diagnostic Marker for Assessing Antibody Responses in Patients with Hypogammaglobulinaemia

THON, Vojtěch; Marcela VLKOVÁ; Zita CHOVANCOVÁ; Jiří LITZMAN; Jindřich LOKAJ et al.

Základní údaje

Originální název

Flow Based Enumeration of Plasmablasts in Peripheral Blood After Vaccination as a Novel Diagnostic Marker for Assessing Antibody Responses in Patients with Hypogammaglobulinaemia

Autoři

THON, Vojtěch; Marcela VLKOVÁ; Zita CHOVANCOVÁ; Jiří LITZMAN a Jindřich LOKAJ

Vydání

Rijeka, Clinical Flow Cytometry - Emerging Applications, od s. 125-142, 18 s. Biochemistry, Genetics and Molecular Biology, 2012

Nakladatel

InTech

Další údaje

Jazyk

angličtina

Typ výsledku

Kapitola resp. kapitoly v odborné knize

Obor

30102 Immunology

Stát vydavatele

Chorvatsko

Utajení

není předmětem státního či obchodního tajemství

Forma vydání

elektronická verze "online"

Odkazy

URL

Označené pro přenos do RIV

Ano

Kód RIV

RIV/00216224:14110/12:00060403

Organizační jednotka

Lékařská fakulta

ISBN

978-953-51-0575-6

Klíčová slova anglicky

Peripheral Blood; Diagnostics; Hypogammaglobulinaemia; Flow Based Enumeration

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 20. 4. 2013 10:40, Ing. Mgr. Věra Pospíšilíková

Anotace

V originále

Hypogammaglobulinaemic patients are often started on immunoglobulin substitution therapy before antibody production is adequately evaluated. In such a situation, it is difficult to segregate transferred from antigen-induced specific antibody. Therefore we characterized changes in B-cell subpopulations in hypogammaglobulinaemic patients, including plasmablasts, in peripheral blood by flow cytometry after in vivo antigen challenge. We investigated the specificity of antibody production on the B-cell level by ELISPOT, which is independent of substitution therapy.

Návaznosti

7E08062, projekt VaV

Název: Pathophysiology and Natural Course of Primary Antibody Deficiency (PAD) Syndromes

Investor: Ministerstvo školství, mládeže a tělovýchovy ČR, Pathophysiology and Natural Course of Primary Antibody Deficiency (PAD) Syndromes

Citovat

THON, Vojtěch; Marcela VLKOVÁ; Zita CHOVANCOVÁ; Jiří LITZMAN a Jindřich LOKAJ. Flow Based Enumeration of Plasmablasts in Peripheral Blood After Vaccination as a Novel Diagnostic Marker for Assessing Antibody Responses in Patients with Hypogammaglobulinaemia. Online. In Clinical Flow Cytometry - Emerging Applications. Rijeka: InTech, 2012, s. 125-142. Biochemistry, Genetics and Molecular Biology. ISBN 978-953-51-0575-6.

@inbook{987327,
   author = {Thon, Vojtěch and Vlková, Marcela and Chovancová, Zita and Litzman, Jiří and Lokaj, Jindřich},
   address = {Rijeka},
   booktitle = {Clinical Flow Cytometry - Emerging Applications},
   keywords = {Peripheral Blood; Diagnostics; Hypogammaglobulinaemia; Flow Based Enumeration},
   howpublished = {elektronická verze "online"},
   language = {eng},
   location = {Rijeka},
   isbn = {978-953-51-0575-6},
   pages = {125-142},
   publisher = {InTech},
   title = {Flow Based Enumeration of Plasmablasts in Peripheral Blood After Vaccination as a Novel Diagnostic Marker for Assessing Antibody Responses in Patients with Hypogammaglobulinaemia},
   url = {http://cdn.intechopen.com/pdfs/37060/InTechFlow_based_enumeration_of_plasmablasts_in_peripheral_blood_after_vaccination_as_a_novel_diagnostic_marker_for_assessing_antibody_responses_in_patients_with_hypogammaglobulinaemia.pdf},
   year = {2012}
}

TY  - CHAP
ID  - 987327
AU  - Thon, Vojtěch - Vlková, Marcela - Chovancová, Zita - Litzman, Jiří - Lokaj, Jindřich
PY  - 2012
TI  - Flow Based Enumeration of Plasmablasts in Peripheral Blood After Vaccination as a Novel Diagnostic Marker for Assessing Antibody Responses in Patients with Hypogammaglobulinaemia
VL  - Biochemistry, Genetics and Molecular Biology
PB  - InTech
CY  - Rijeka
SN  - 9789535105756
KW  - Peripheral Blood
KW  - Diagnostics
KW  - Hypogammaglobulinaemia
KW  - Flow Based Enumeration
UR  - http://cdn.intechopen.com/pdfs/37060/InTechFlow_based_enumeration_of_plasmablasts_in_peripheral_blood_after_vaccination_as_a_novel_diagnostic_marker_for_assessing_antibody_responses_in_patients_with_hypogammaglobulinaemia.pdf
L2  - http://cdn.intechopen.com/pdfs/37060/InTechFlow_based_enumeration_of_plasmablasts_in_peripheral_blood_after_vaccination_as_a_novel_diagnostic_marker_for_assessing_antibody_responses_in_patients_with_hypogammaglobulinaemia.pdf
N2  - Hypogammaglobulinaemic patients are often started on immunoglobulin substitution therapy before antibody production is adequately evaluated. In such a situation, it is difficult to segregate transferred from antigen-induced specific antibody. Therefore we characterized changes in B-cell subpopulations in hypogammaglobulinaemic patients, including plasmablasts, in peripheral blood by flow cytometry after in vivo antigen challenge. We investigated the specificity of antibody production on the B-cell level by ELISPOT, which is independent of substitution therapy.
ER  -

THON, Vojtěch; Marcela VLKOVÁ; Zita CHOVANCOVÁ; Jiří LITZMAN a Jindřich LOKAJ. Flow Based Enumeration of Plasmablasts in Peripheral Blood After Vaccination as a Novel Diagnostic Marker for Assessing Antibody Responses in Patients with Hypogammaglobulinaemia. Online. In \textit{Clinical Flow Cytometry - Emerging Applications}. Rijeka: InTech, 2012, s.~125-142. Biochemistry, Genetics and Molecular Biology. ISBN~978-953-51-0575-6.

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