Sequential modifications in class II transactivator isoform 1
induced by lipopolysaccharide stimulate major
histocompatibility complex class II transcription in
macrophages

J 2006

Sequential modifications in class II transactivator isoform 1 induced by lipopolysaccharide stimulate major histocompatibility complex class II transcription in macrophages

DROZINA, Gorazd, Jiří KOHOUTEK, Tadashi NISHIYA a B Matija PETERLIN

Základní údaje

Originální název

Sequential modifications in class II transactivator isoform 1 induced by lipopolysaccharide stimulate major histocompatibility complex class II transcription in macrophages

Autoři

DROZINA, Gorazd, Jiří KOHOUTEK, Tadashi NISHIYA a B Matija PETERLIN

Vydání

Journal of Biological Chemistry, Bethesda, USA, Amer. Soc. Biochem. Mol. Biol. 2006, 0021-9258

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

Genetika a molekulární biologie

Stát vydavatele

Spojené státy

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 5.808

Organizační jednotka

Středoevropský technologický institut

DOI

http://dx.doi.org/10.1074/jbc.M608538200

UT WoS

000243033900024

Klíčová slova anglicky

ELONGATION-FACTOR-B; UBIQUITIN-MEDIATED PROTEOLYSIS; HUMAN-IMMUNODEFICIENCY-VIRUS; CREB BINDING-PROTEIN; TOLL-LIKE RECEPTORS; ACTIVATE TRANSCRIPTION; DIFFERENTIAL USAGE; DENDRITIC CELLS; CIITA FUNCTION; IFN-GAMMA

Štítky

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 22. 7. 2012 07:30, Olga Křížová

Anotace

V originále

By presenting antigenic peptides on major histocompatibility complex class (MHC) II determinants to CD4(+) T cells, macrophages help to direct the establishment of adaptive immunity. We found that in these cells, lipopolysaccharide stimulates the expression of MHC II genes via the activation of Erk1/2, which is mediated by Toll-like receptor 4. Erk1/2 then phosphorylates the serine at position 357, which is located in a degron of CIITA isoform 1 that leads to its monoubiquitylation. Thus modified, CIITA isoform 1 binds P-TEFb, which mediates the elongation of RNA polymerase II and co-transcriptional processing of nascent transcripts. This induction leads to the expression of MHC II genes. Subsequent polyubiquitylation results in the degradation of CIITA isoform 1. Thus, the signaling cascade from Toll-like receptor 4 to CIITA isoform 1 represents one connection between innate and adaptive immunity in macrophages.

Citovat

DROZINA, Gorazd, Jiří KOHOUTEK, Tadashi NISHIYA a B Matija PETERLIN. Sequential modifications in class II transactivator isoform 1 induced by lipopolysaccharide stimulate major histocompatibility complex class II transcription in macrophages. Journal of Biological Chemistry. Bethesda, USA: Amer. Soc. Biochem. Mol. Biol., 2006, roč. 281, č. 52, s. 39963-39970. ISSN 0021-9258. Dostupné z: https://dx.doi.org/10.1074/jbc.M608538200.

@article{987487,
   author = {Drozina, Gorazd and Kohoutek, Jiří and Nishiya, Tadashi and Peterlin, B Matija},
   article_location = {Bethesda, USA},
   article_number = {52},
   doi = {http://dx.doi.org/10.1074/jbc.M608538200},
   keywords = {ELONGATION-FACTOR-B; UBIQUITIN-MEDIATED PROTEOLYSIS; HUMAN-IMMUNODEFICIENCY-VIRUS; CREB BINDING-PROTEIN; TOLL-LIKE RECEPTORS; ACTIVATE TRANSCRIPTION; DIFFERENTIAL USAGE; DENDRITIC CELLS; CIITA FUNCTION; IFN-GAMMA},
   language = {eng},
   issn = {0021-9258},
   journal = {Journal of Biological Chemistry},
   title = {Sequential modifications in class II transactivator isoform 1 induced by lipopolysaccharide stimulate major histocompatibility complex class II transcription in macrophages},
   url = {http://www.jbc.org/content/early/2006/11/09/jbc.M608538200.full.pdf+html},
   volume = {281},
   year = {2006}
}

TY  - JOUR
ID  - 987487
AU  - Drozina, Gorazd - Kohoutek, Jiří - Nishiya, Tadashi - Peterlin, B Matija
PY  - 2006
TI  - Sequential modifications in class II transactivator isoform 1 induced by lipopolysaccharide stimulate major histocompatibility complex class II transcription in macrophages
JF  - Journal of Biological Chemistry
VL  - 281
IS  - 52
SP  - 39963-39970
EP  - 39963-39970
PB  - Amer. Soc. Biochem. Mol. Biol.
SN  - 00219258
KW  - ELONGATION-FACTOR-B
KW  - UBIQUITIN-MEDIATED PROTEOLYSIS
KW  - HUMAN-IMMUNODEFICIENCY-VIRUS
KW  - CREB BINDING-PROTEIN
KW  - TOLL-LIKE RECEPTORS
KW  - ACTIVATE TRANSCRIPTION
KW  - DIFFERENTIAL USAGE
KW  - DENDRITIC CELLS
KW  - CIITA FUNCTION
KW  - IFN-GAMMA
UR  - http://www.jbc.org/content/early/2006/11/09/jbc.M608538200.full.pdf+html
N2  - By presenting antigenic peptides on major histocompatibility complex class (MHC) II determinants to CD4(+) T cells, macrophages help to direct the establishment of adaptive immunity. We found that in these cells, lipopolysaccharide stimulates the expression of MHC II genes via the activation of Erk1/2, which is mediated by Toll-like receptor 4. Erk1/2 then phosphorylates the serine at position 357, which is located in a degron of CIITA isoform 1 that leads to its monoubiquitylation. Thus modified, CIITA isoform 1 binds P-TEFb, which mediates the elongation of RNA polymerase II and co-transcriptional processing of nascent transcripts. This induction leads to the expression of MHC II genes. Subsequent polyubiquitylation results in the degradation of CIITA isoform 1. Thus, the signaling cascade from Toll-like receptor 4 to CIITA isoform 1 represents one connection between innate and adaptive immunity in macrophages.
ER  -

DROZINA, Gorazd, Jiří KOHOUTEK, Tadashi NISHIYA a B Matija PETERLIN. Sequential modifications in class II transactivator isoform 1 induced by lipopolysaccharide stimulate major histocompatibility complex class II transcription in macrophages. \textit{Journal of Biological Chemistry}. Bethesda, USA: Amer. Soc. Biochem. Mol. Biol., 2006, roč.~281, č.~52, s.~39963-39970. ISSN~0021-9258. Dostupné z: https://dx.doi.org/10.1074/jbc.M608538200.

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