| JAROŠOVÁ, Barbora, Luděk BLÁHA, Branislav VRANA, T. RANDÁK, R. GRABIC, J. P. GIESY a Klára HILSCHEROVÁ. Changes in concentrations of hydrophilic organic contaminants and of endocrine-disrupting potential downstream of small communities located adjacent to headwaters. Environment International. OXFORD, ENGLAND: PERGAMON-ELSEVIER SCIENCE LTD, 2012, roč. 45, SEPTEMBER, s. 22-31. ISSN 0160-4120. Dostupné z: https://dx.doi.org/10.1016/j.envint.2012.04.001. |
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@article{988309,
author = {Jarošová, Barbora and Bláha, Luděk and Vrana, Branislav and Randák, T. and Grabic, R. and Giesy, J. P. and Hilscherová, Klára},
article_location = {OXFORD, ENGLAND},
article_number = {SEPTEMBER},
doi = {http://dx.doi.org/10.1016/j.envint.2012.04.001},
keywords = {Androgen; Dioxin-like activity; Estrogen; In vitro assay; POCIS; Waste Water Treatment Plant},
language = {eng},
issn = {0160-4120},
journal = {Environment International},
title = {Changes in concentrations of hydrophilic organic contaminants and of endocrine-disrupting potential downstream of small communities located adjacent to headwaters.},
volume = {45},
year = {2012}
}
TY - JOUR
ID - 988309
AU - Jarošová, Barbora - Bláha, Luděk - Vrana, Branislav - Randák, T. - Grabic, R. - Giesy, J. P. - Hilscherová, Klára
PY - 2012
TI - Changes in concentrations of hydrophilic organic contaminants and of endocrine-disrupting potential downstream of small communities located adjacent to headwaters.
JF - Environment International
VL - 45
IS - SEPTEMBER
SP - 22-31
EP - 22-31
PB - PERGAMON-ELSEVIER SCIENCE LTD
SN - 01604120
KW - Androgen
KW - Dioxin-like activity
KW - Estrogen
KW - In vitro assay
KW - POCIS
KW - Waste Water Treatment Plant
N2 - Endocrine-disruptive potential and concentrations of polar organic contaminants were measured in seven headwaters flowing through relatively unpolluted areas of the Czech Republic. Towns with Wastewater Treatment Plant (WWTP) discharges were the first known sources of anthropogenic pollution in the areas. River water was sampled several kilometers upstream (US) and several tens of meters downstream (DS) of the WWTP discharges, by use of Pesticide and Pharmaceutical Polar Organic Integrative Samplers (POCIS-Pest, POCIS-Pharm). Extracts of passive samplers were tested by use of a battery of in vitro bioassays to determine overall non-specific cytotoxicity, endocrine-disruptive (ED) potential and dioxin-like toxicity. The extracts were also used for quantification of polar organics. There was little toxicity to cells caused by most extracts of POCIS. Estrogenicity was detected in all types of samples even though US locations are considered to be background. At US locations, concentrations of estrogen equivalents (EEq) ranged from less than the detection limits (LOD) to 0.5 ng EEq/POCIS. Downstream concentrations of EEqs ranged from less than LOD to 4.8 ng EEq/POCIS. Concentrations of EEq in POCIS extracts from all DS locations were 1 to 14 times greater than those at US locations. Concentrations of EEq measured in extracts of POCIS-Pest and POCIS-Pharm were in a good agreement. Neither antiestrogenic nor anti/androgenic activities were detected. Concentrations of 2.3.7.8-TCDD equivalents (TEq(bio)) were detected in both types of POCIS at Concentrations ranging from less than the LOD to 0.39 ng TEq(bio)/POCIS. Nearly all extracts of POCIS-Pharm contained greater concentrations of TEq(bio) activity than extracts of POCIS-Pest. Concentrations of pesticides and pharmaceuticals in extracts of POCIS were generally small at all sampling sites, but levels of some pharmaceuticals were significantly greater in both types of POCIS from DS locations.
ER -
JAROŠOVÁ, Barbora, Luděk BLÁHA, Branislav VRANA, T. RANDÁK, R. GRABIC, J. P. GIESY a Klára HILSCHEROVÁ. Changes in concentrations of hydrophilic organic contaminants and of endocrine-disrupting potential downstream of small communities located adjacent to headwaters. \textit{Environment International}. OXFORD, ENGLAND: PERGAMON-ELSEVIER SCIENCE LTD, 2012, roč.~45, SEPTEMBER, s.~22-31. ISSN~0160-4120. Dostupné z: https://dx.doi.org/10.1016/j.envint.2012.04.001.
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