Investigation into the concentration of serum pre-albumin nad
trace elements to monitor the nutritional status of
phenylketonuric and hyperphenylalninemic patients

a 2012

Investigation into the concentration of serum pre-albumin nad trace elements to monitor the nutritional status of phenylketonuric and hyperphenylalninemic patients

PROCHÁZKOVÁ, Dagmar; Lucie KOLBOVÁ; Jiří JARKOVSKÝ; Hana VINOHRADSKÁ; Petra KONEČNÁ et al.

Základní údaje

Originální název

Investigation into the concentration of serum pre-albumin nad trace elements to monitor the nutritional status of phenylketonuric and hyperphenylalninemic patients

Název česky

vyšetření prealbuminu a stopových prvků v séru u pacientů s PKU a HPA ke sledování jejich nutričního stavu

Autoři

PROCHÁZKOVÁ, Dagmar; Lucie KOLBOVÁ; Jiří JARKOVSKÝ ; Hana VINOHRADSKÁ; Petra KONEČNÁ a Zdeněk DOLEŽEL

Vydání

J Inherit Metab Dis 35, 2012,Suppl1, S 44, 2012

Další údaje

Jazyk

angličtina

Typ výsledku

Konferenční abstrakt

Obor

30209 Paediatrics

Stát vydavatele

Česká republika

Utajení

není předmětem státního či obchodního tajemství

Impakt faktor

Impact factor: 4.070

Označené pro přenos do RIV

Organizační jednotka

Lékařská fakulta

ISSN

UT WoS

000307513100146

Klíčová slova česky

PKU HPA prealbumin stopové prvky

Klíčová slova anglicky

PKU HPA pre-albumin trace elements

Změněno: 8. 1. 2013 10:35, doc. MUDr. Dagmar Procházková, Ph.D.

Anotace

V originále

Aim: Phenylketonuria is an inherited disorder of metabolism of the amino acid phenylalanine caused by a deficit of the enzyme phenylalaninhydroxylase. It is treated with a low-protein diet containing a low content of phenylalanine to prevent mental affection of the patient. The objective of the present study was to assess the compliance of our phenylketonuric (PKU) and hyperphenylalaninemic (HPA) patients; to determine the concentration of serum pre-albumin, selenium, zinc and iron to discover the potential correlation between the amount of proteins in food and their metabolic control. Methods: We studied 174 patients of which 113 were children (age 1-18), 60 with PKU and 53 with HPA and 61 were adults (age 18-42), 51 with PKU and 10 with HPA. Results: We did not prove a statistically significant difference in the concentration of serum pre-albumin, zinc and iron among the respective groups. We approved statistically significant difference in serum selenium concentrations of adult PKU and HPA patients (p=0.006; Mann-Whitney U test). Conclusions: The concentration of serum selenium could be used as indirect marker in evaluation of the risk of late complications of dietary therapy.

Citovat

PROCHÁZKOVÁ, Dagmar; Lucie KOLBOVÁ; Jiří JARKOVSKÝ; Hana VINOHRADSKÁ; Petra KONEČNÁ a Zdeněk DOLEŽEL. Investigation into the concentration of serum pre-albumin nad trace elements to monitor the nutritional status of phenylketonuric and hyperphenylalninemic patients. In J Inherit Metab Dis 35, 2012,Suppl1, S 44. 2012. ISSN 0141-8955.

@proceedings{989618,
   author = {Procházková, Dagmar and Kolbová, Lucie and Jarkovský, Jiří and Vinohradská, Hana and Konečná, Petra and Doležel, Zdeněk},
   booktitle = {J Inherit Metab Dis 35, 2012,Suppl1, S 44},
   keywords = {PKU HPA pre-albumin trace elements},
   language = {eng},
   title = {Investigation into the concentration of serum pre-albumin nad trace elements to monitor the nutritional status of phenylketonuric and hyperphenylalninemic patients},
   year = {2012}
}

TY  - CONF
ID  - 989618
AU  - Procházková, Dagmar - Kolbová, Lucie - Jarkovský, Jiří - Vinohradská, Hana - Konečná, Petra - Doležel, Zdeněk
PY  - 2012
TI  - Investigation into the concentration of serum pre-albumin nad trace elements to monitor the nutritional status of phenylketonuric and hyperphenylalninemic patients
KW  - PKU HPA pre-albumin trace elements
N2  - Aim: Phenylketonuria is an inherited disorder of metabolism of the amino acid phenylalanine caused by a deficit of the enzyme phenylalaninhydroxylase. It is treated with a low-protein diet containing a low content of phenylalanine to prevent mental affection of the patient. The objective of the present study was to assess the compliance of our phenylketonuric (PKU) and hyperphenylalaninemic (HPA) patients; to determine the concentration of serum pre-albumin, selenium, zinc and iron to discover the potential correlation between the amount of proteins in food and their metabolic control. Methods: We studied 174 patients of which 113 were children (age 1-18), 60 with PKU and 53 with HPA and 61 were adults (age 18-42), 51 with PKU and 10 with HPA. Results: We did not prove a statistically significant difference in the concentration of serum pre-albumin, zinc and iron among the respective groups. We approved statistically significant difference in serum selenium concentrations of adult PKU and HPA patients (p=0.006; Mann-Whitney U test). Conclusions: The concentration of serum selenium could be used as indirect marker in evaluation of the risk of late complications of dietary therapy.
ER  -

PROCHÁZKOVÁ, Dagmar; Lucie KOLBOVÁ; Jiří JARKOVSKÝ; Hana VINOHRADSKÁ; Petra KONEČNÁ a Zdeněk DOLEŽEL. Investigation into the concentration of serum pre-albumin nad trace elements to monitor the nutritional status of phenylketonuric and hyperphenylalninemic patients. In \textit{J Inherit Metab Dis 35, 2012,Suppl1, S 44}. 2012. ISSN~0141-8955.

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