BVBC021p Biochemistry - lecture

Faculty of Medicine
spring 2027
Extent and Intensity
2/0/0. 3 credit(s). Type of Completion: zk (examination).
In-person direct teaching
Teacher(s)
Mgr. Marie Tomandlová, Ph.D. (lecturer)
doc. RNDr. Jiří Dostál, CSc. (lecturer)
doc. RNDr. Josef Tomandl, Ph.D. (lecturer)
Iva Audy (assistant)
RNDr. Hana Paulová, CSc. (assistant)
Mgr. Jiří Slanina, Ph.D. (assistant)
MUDr. Michaela Králíková, Ph.D. (alternate examiner)
Guaranteed by
Mgr. Marie Tomandlová, Ph.D.
Department of Biochemistry – Theoretical Departments – Faculty of Medicine
Contact Person: Mgr. Marie Tomandlová, Ph.D.
Supplier department: Department of Biochemistry – Theoretical Departments – Faculty of Medicine
Prerequisites (in Czech)
BVLC011s Med.Chem.-seminar && BVLC011c Medical Chemistry -p
Course Enrolment Limitations
The course is only offered to the students of the study fields the course is directly associated with.
fields of study / plans the course is directly associated with
Abstract
The aim of the course is to obtain knowledge on essential metabolic processes on the cell level.
Learning outcomes
In the end of the course will students:
- understand the properties and function of enzymes
- describes basic catabolic and anabolic pathways of carbohydrate, lipid and protein metabolism, and their relationships
- understand the principles of energy production, utilization and deposition at the cellular level
- explain the function of cell membranes and the transport processes on the membrane
- describe protein synthesis, understand the relationship between protein structure and function
- explain the function of hemoglobin in oxygen transport and maintaining acid-base balance
Key topics
  • Enzymes, properties, classification, quantification, kinetics. Factors influencing the speed of enzyme reactions.
  • Enzyme cofactors. Introduction to Metabolism. Macroergic compounds.
  • Three phases of nutrient catabolism. Citrate cycle. Respiratory chain. Oxidative phosphorylation. Reactive oxygen species, antioxidants.
  • Digestion of carbohydrates. Introduction to Carbohydrate Metabolism. Glycolysis. Gluconeogenesis. Synthesis and breakdown of glycogen.
  • Pentose cycle. Metabolism of fructose and galactose. Mutual transformations of carbohydrates in the cell, formation of carbohydrate derivatives.
  • Protein digestion and intracellular degradation.
  • General mechanisms of biodegradation of amino acids. Ammonia detoxification and transport. Metabolism of individual amino acids.
  • Digestion of lipids. Fatty acid metabolism. Ketogenesis and ketolysis. Metabolism of triacylglycerols. Metabolism of phospholipids and glycolipids. Eicosanoids. Metabolism of cholesterol and bile acids.
  • Synthesis and degradation of heme. Hemoglobin.
  • Metabolism of nucleotides and their bases. DNA replication.
  • DNA transcription. Regulation of gene expression.
  • Proteosynthesis, post-translational modifications.
Study resources and literature
    required literature
  • Studijní materiály k předmětu dostupné v IS MU.
    recommended literature
  • MATOUŠ, Bohuslav. Základy lékařské chemie a biochemie. 1. vyd. Praha: Galén, 2010, xv, 540. ISBN 9788072627028. info
  • LEDVINA, Miroslav; Alena STOKLASOVÁ and Jaroslav CERMAN. Biochemie pro studující medicíny. 3. vydání. Praha: Univerzita Karlova, nakladatelství Karolinum, 2020, 269 stran. ISBN 9788024647487. info
  • FERRIER, Denise R. Biochemistry. Seventh edition. Philadelphia: Wolters Kluwer, 2017, viii, 567. ISBN 9781496363541. info
Approaches, practices, and methods used in teaching
Lecture
Method of verifying learning outcomes and course completion requirements
Oral examination.
Language of instruction
Czech
Further comments (probably available only in Czech)
Information on completion of the course: přistoupení ke zkoušce je podmíněno úspěšným ukončením předmětů BVLC011p a BVBC021s.
The course is taught annually.
The course is taught every week.
Listed among pre-requisites of other courses
Teacher's information
Information on the examination, including the topics included in the examination, is available in the IS MU Study Materials.
The course is also listed under the following terms spring 2026.
  • Enrolment Statistics (spring 2027, recent)
  • Permalink: https://is.muni.cz/course/med/spring2027/BVBC021p