aVLBC0422s Biochemistry II - seminar

Faculty of Medicine
spring 2027
Extent and Intensity
0/3/0. 3 credit(s). Type of Completion: z (credit).
In-person direct teaching
Teacher(s)
doc. RNDr. Jiří Dostál, CSc. (seminar tutor)
prof. RNDr. Eva Táborská, CSc. (seminar tutor)
doc. RNDr. Josef Tomandl, Ph.D. (seminar tutor)
Iva Audy (assistant)
Mgr. Jana Gregorová, Ph.D. (assistant)
MUDr. Michaela Králíková, Ph.D. (assistant)
RNDr. Hana Paulová, CSc. (assistant)
doc. Mgr. Ondřej Peš, Ph.D. (assistant)
Mgr. Jiří Slanina, Ph.D. (assistant)
Mgr. Marie Tomandlová, Ph.D. (assistant)
Guaranteed by
doc. RNDr. Josef Tomandl, Ph.D.
Department of Biochemistry – Theoretical Departments – Faculty of Medicine
Contact Person: MUDr. Michaela Králíková, Ph.D.
Supplier department: Department of Biochemistry – Theoretical Departments – Faculty of Medicine
Prerequisites (in Czech)
aVLBC0321s Biochemistry I - seminar && aVLFY0321c Physiology I - practice && aVLFY0321s Physiology I - seminar
Course Enrolment Limitations
The course is only offered to the students of the study fields the course is directly associated with.
fields of study / plans the course is directly associated with
Abstract
The seminars complement the lecture-based course Biochemistry II and focus on practising and applying key biochemical principles. Their aim is to deepen students’ understanding of intermediary metabolism and its regulation under various physiological and pathological conditions, to clarify the metabolic characteristics of individual organs and tissues, and to consolidate the principles of maintaining homeostasis, including acid–base balance. The instruction emphasises problem‑solving, interpretation of laboratory results, and linking biochemical concepts with clinical practice.
Learning outcomes
Upon successful completion of the seminars, the student will be able to:
  • explain the interrelationships between nutrient metabolism in different physiological and pathological states;
  • describe the metabolic characteristics of major organs and tissues and discuss their disorders in relation to diseases;
  • understand and apply the principles of homeostasis and acid–base balance when solving model clinical situations;
  • discuss the composition of body fluids and their changes in the context of homeostatic disturbances;
  • explain the principles of metabolic regulation at the molecular, cellular, and systemic levels.
Key topics
  • Enzymes in clinical diagnostics. Methods in clinical biochemistry. Analysers and POCT systems.
  • Blood glucose. Protein metabolism. Proteins in nutrition. Transport forms of ammonia.
  • Lipoproteins and their metabolism. Cholesterol transport and daily turnover.
  • Interrelations of major metabolic pathways in different physiological states. Malnutrition, obesity, metabolic syndrome, and stress metabolism.
  • Liver functions. Role of the liver in nutrient metabolism. Heme catabolism, hyperbilirubinaemia.
  • Hepatic metabolism of hormones and vitamins. Iron metabolism. Xenobiotic biotransformation. Alcohol metabolism.
  • Internal environment: homeostasis of water and ions (Na⁺, K⁺), osmolality, regulation, and disorders.
  • Acid–base balance: parameters, regulation, disorders. Buffer systems. Transport of O₂ and CO₂.
  • Kidney function: glomerular filtration, tubular reabsorption, and secretion. Diuretics.
  • Receptors for neurotransmitters and hormones. Major signalling pathways.
  • Steroid and thyroid hormones.
  • Biochemistry of muscle function. Effects of nitric oxide. Energetics of muscle work.
  • Metabolism of calcium, magnesium, phosphates, fluoride, and iodine.
  • Extracellular matrix. Metabolism of connective tissue and skin. Bone markers.
Study resources and literature
    required literature
  • Interactive Syllabus of the course in IS MU.
  • RODWELL, Victor W.; David A. BENDER; Kathleen M. BOTHAM; Peter J. KENNELLY and P. Anthony WEIL. Harper's illustrated biochemistry. Thirty-first edition. New York: McGraw-Hill, 2018, x, 789. ISBN 9781260288421. info
    recommended literature
  • LIEBERMAN, Michael; Allan D. MARKS and Alisa PEET. Marks' basic medical biochemistry : a clinical approach. Illustrated by Matthew Chansky. 4th ed. Baltimore: Lippincott, Williams & Wilkins, 2013, ix, 1014. ISBN 9781451100037. info
  • Recommended literature from medical physiology in the course aVLFY0422p.
Approaches, practices, and methods used in teaching
Seminar‑based instruction focused on the discussion of assigned topics and the solution of model examples.
Method of verifying learning outcomes and course completion requirements
Credit. Conditions for giving the course-unit credit:
1) completion of all seminars and 2) completion of in-term tests.
Language of instruction
English
Further comments (probably available only in Czech)
The course is taught annually.
The course is taught every week.
General note: Successful completion of the course is a condition for access to the exam in the course aVLBC0422p.
Listed among pre-requisites of other courses
Teacher's information

Detailed information on the organisation, teaching methods, and completion requirements of the course is available in the Study Materials section of the IS MU.

Consultation is possible upon personal arrangement with the teacher.

The course is also listed under the following terms Spring 2017, Spring 2018, spring 2019, spring 2020, spring 2021, spring 2022, spring 2023, spring 2024, spring 2025, spring 2026.
  • Enrolment Statistics (spring 2027, recent)
  • Permalink: https://is.muni.cz/course/med/spring2027/aVLBC0422s