aFANM1_15 NMR Structural Analysis of Organic Compounds

Faculty of Pharmacy
Autumn 2025

The course is not taught in Autumn 2025

Extent and Intensity
0/2/0. 3 credit(s). Type of Completion: zk (examination).
Teacher(s)
PharmDr. Jan Otevřel, Ph.D. (lecturer)
Mgr. David Švestka, Ph.D. (seminar tutor)
Guaranteed by
PharmDr. Jan Otevřel, Ph.D.
Department of Chemical Drugs – Departments – Faculty of Pharmacy
Course Enrolment Limitations
The course is only offered to the students of the study fields the course is directly associated with.
fields of study / plans the course is directly associated with
Abstract
The subject aims to acquaint students not only with the theoretical foundations of nuclear magnetic resonance, but above all with the practical interpretation of measured spectra. The acquired knowledge will enable students to independently process and analyze spectra obtained using NMR and determine the structure of organic compounds based on these spectra.
Learning outcomes
After completing the course, the student is able to explain the theoretical foundations of NMR spectroscopy, process and interpret NMR spectra (mainly 1H, 13C, 19F, 31P), orientate themselves in the basic issues of 2D NMR spectra, confirm or derive the resulting structure of organic substances from the presented spectra.
Key topics
  • 1. Theoretical foundations of NMR, signal generation, types of nuclear interactions, chemical shift, interaction constant
  • 2. Construction of spectrometers, sample preparation and measurement, solvents used in  NMR, computer programs used to process NMR spectra
  • 3. Symmetry of molecules and chemical equivalence of nuclei, magnetic equivalence of nuclei, effects on chemical shift
  • 4. Formation of multiplets, notation of spin systems, analysis of simple spin systems.
  • 5. Analysis of more complex spin systems and multiplets, dynamic processes in  NMR
  • 6. Interpretation and recording of 1H NMR spectra
  • 7. Specifics of 13C NMR, interpretation and recording of 13C NMR, decaplink, multipulse experiments (APT, ...)
  • 8. Specificity of 19F, 31P and other elements in NMR, interpretation and recording of 19F NMR
  • 9. Tasks to practice the interpretation of spectra
  • 10. Homo- and heteronuclear 2D NMR experiments
  • 11. Tasks to practice the interpretation of spectra
  • 12. NMR as a tool for quantitative analysis
Study resources and literature
    recommended literature
  • SILVERSTEIN, Robert M. Spectrometric identification of organic compounds. 8th ed. Hoboken: Wiley,, 2015. ISBN 978-0-470-61637-6. info
Approaches, practices, and methods used in teaching
seminars, class discussion, work with PC applications and laboratory tools
Method of verifying learning outcomes and course completion requirements
Attending the seminars, submitting the individual assignments. Final examination - oral and practical part.
Language of instruction
English
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