FDCFB_FAF Medicinal Chemistry

Faculty of Pharmacy
Autumn 2021
Extent and Intensity
1/1/0. 30 credit(s). Type of Completion: zk (examination).
Teacher(s)
prof. RNDr. Jozef Csöllei, CSc. (lecturer)
doc. PharmDr. Oldřich Farsa, Ph.D. (lecturer)
Guaranteed by
prof. RNDr. Jozef Csöllei, CSc.
Faculty of Pharmacy
Prerequisites (in Czech)
FAKULTA(FaF)
Course Enrolment Limitations
The course is only offered to the students of the study fields the course is directly associated with.
fields of study / plans the course is directly associated with
Course objectives
The subject serves to broaden and deepen the knowledge of biologically active substances according to their classification into individual pharmacotherapeutic groups or according to the classification of the drug in terms of its effect at the molecular level (in terms of its mechanism of action at the level of receptor, enzyme, ion channel, etc.). It also deals with methods of molecular design, study of chemical structure relations and biological activity of pharmaceuticals in relation to physicochemical properties and studies the biological activity of the drug in relation to its spatial arrangement, including the influence of chirality on its efficiency and biotransformation.
Learning outcomes
Within the course Pharmaceutical Chemistry, the student will acquires basic knowledge in the study of the relationship between chemical structure and biological activity, knowledge of physicochemical and analytical properties of drugs, biochemical and pharmacological properties of potential or in therapeutic practice drugs. In individual therapeutic groups of drugs, he will acquires knowledge about the mechanism of action of drugs at the molecular or enzymatic level and the direction of research of potential drugs using modern analytical and synthetic procedures (drug design, etc.)
Syllabus
  • General knowledge:
    - nonspecific and specific action of drugs - the importance of physicochemical properties, the binding of the drug to the target endogenous structure
    - quantitative relationships between chemical structure and biological activity and molecular modeling in drug development
    - drug metabolism - 1st and 2nd phase of biotransformation
    Therapeutic drug groups:
    - substances affecting the peripheral nervous system
    - substances affecting the central nervous system
    - substances affecting the cardiovascular and renal system
    - drugs that affect blood clotting
    - drugs that affect the nociceptive system and the therapy of the locomotory system
    - antihistamines, antiallergics, prostanoids, leukotrienes, antiserotoninergics and migraine prophylaxis
    - digestive and excretory drugs
    - therapy of respiratory diseases
    - medicines with an effect on the function of the internal secretion glands
    - chemotherapeutics - microbial, viral, parasitic and cancerous diseases
Literature
    recommended literature
  • M. Wolff. Burger´s Medicinal Chemistry I. - V. díl, V. vydání , Wiley Interscience, N. York, Chichester, Brisbane, Toronto, Singapore 1995?1998. info
  • Auterhoff H., Knabe H. J., Höltje H. D. Lehrbuch der Pharmazeutischen Chemie. Stuttgart, 1999. info
    not specified
  • Bultinck,P., De Winter, H., Langenaeker, W., Tollenare, J. P.:. Computational medicinal chemistry for drug discovery, Taylor and Francis, 2003, ISBN: 0824747747. info
  • Cairns, D.:. Essentials of pharmaceutical chemistry, Deutscher Apotheker Verlag, 2003, ISBN: 3769234006. info
  • Wiliams D. A., Lemke T L.:. Foye´s Principles of Medicinal Chemistry, Fifth Edition, Lippincot Williams and Wilkins Philadelphia, Baltimore 2002. info
  • Reddy, I. K., Mehvar, R.:. Chirality in drug design and development, Marcel Dekker, Inc., 2004, ISBN: 0824750624. info
  • Wermuth, C. G.:. The praktice of medicinal chemistry, Elsevier - Harcourt, 2008, ISBN: 012374194. info
Teaching methods
Active use of Medicinal chemistry textbooks, work with scientific and professional publications and personal consultations.
Assessment methods
oral examination
Language of instruction
Czech
Further comments (probably available only in Czech)
The course can also be completed outside the examination period.
The course is taught each semester.
Teacher's information
To acquire knowledge and skills in the field of chemical drugs according to their classification into individual pharmacotherapeutic groups in relation to the chemical structure and biological activity and detailed study of selected chapters related to the solved problems of the student.
The course is also listed under the following terms Spring 2020, Autumn 2020, Spring 2021, Spring 2022, Autumn 2022, Spring 2023, Autumn 2023, Spring 2024, Autumn 2024, Spring 2025.
  • Enrolment Statistics (Autumn 2021, recent)
  • Permalink: https://is.muni.cz/course/pharm/autumn2021/FDCFB_FAF