FDFCa_FAF Medicinal Chemistry

Faculty of Pharmacy
Autumn 2025
Extent and Intensity
2/0/0. 8 credit(s). Type of Completion: zk (examination).
In-person direct teaching
Teacher(s)
prof. RNDr. Jozef Csöllei, CSc. (lecturer)
Guaranteed by
prof. RNDr. Jozef Csöllei, CSc.
Faculty of Pharmacy
Supplier department: Department of Chemical Drugs – Departments – Faculty of Pharmacy
Course Enrolment Limitations
The course is only offered to the students of the study fields the course is directly associated with.
fields of study / plans the course is directly associated with
Course objectives
The subject serves to broaden and deepen the knowledge of biologically active substances according to their classification into individual pharmacotherapeutic groups or according to the classification of the drug in terms of its effect at the molecular level (in terms of its mechanism of action at the level of receptor, enzyme, ion channel, etc.). It also deals with methods of molecular design, study of chemical structure relations and biological activity of pharmaceuticals in relation to physicochemical properties and studies the biological activity of the drug in relation to its spatial arrangement, including the influence of chirality on its efficiency and biotransformation.
Learning outcomes
Within the course Pharmaceutical Chemistry, the student will acquires basic knowledge in the study of the relationship between chemical structure and biological activity, knowledge of physicochemical and analytical properties of drugs, biochemical and pharmacological properties of potential or in therapeutic practice drugs. In individual therapeutic groups of drugs, he will acquires knowledge about the mechanism of action of drugs at the molecular or enzymatic level and the direction of research of potential drugs using modern analytical and synthetic procedures (drug design, etc.)
Syllabus
General knowledge:
- nonspecific and specific action of drugs - the importance of physicochemical properties, the binding of the drug to the target endogenous structure
- quantitative relationships between chemical structure and biological activity and molecular modeling in drug development
- drug metabolism - 1st and 2nd phase of biotransformation
Therapeutic drug groups:
- substances affecting the peripheral nervous system
- substances affecting the central nervous system
- substances affecting the cardiovascular and renal system
- drugs that affect blood clotting
- drugs that affect the nociceptive system and the therapy of the locomotory system
- antihistamines, antiallergics, prostanoids, leukotrienes, antiserotoninergics and migraine prophylaxis
- digestive and excretory drugs
- therapy of respiratory diseases
- medicines with an effect on the function of the internal secretion glands
- chemotherapeutics - microbial, viral, parasitic and cancerous diseases
Literature
    recommended literature
  • Bultinck,P., De Winter, H., Langenaeker, W., Tollenare, J. P.:. Computational medicinal chemistry for drug discovery, Taylor and Francis, 2003, ISBN: 0824747747. info
  • Cairns, D.:. Essentials of pharmaceutical chemistry, Deutscher Apotheker Verlag, 2003, ISBN: 3769234006. info
  • Wiliams D. A., Lemke T L.:. Foye´s Principles of Medicinal Chemistry, Fifth Edition, Lippincot Williams and Wilkins Philadelphia, Baltimore 2002. info
  • Reddy, I. K., Mehvar, R.:. Chirality in drug design and development, Marcel Dekker, Inc., 2004, ISBN: 0824750624. info
  • Wermuth, C. G.:. The praktice of medicinal chemistry, Elsevier - Harcourt, 2008, ISBN: 012374194. info
  • MALÍK, Ivan. Farmaceutická chémia protivírusových a vybraných protinádorových liečiv. Prvé vydanie. Bratislava: Univerzita Komenského Bratislava, 2022, 467 stran. ISBN 9788022353151. info
  • DOLEŽAL, Martin. Farmaceutická chemie : léčiv působících na kardiovaskulární, trávicí a vylučovací systém. První vydání. Praha: Univerzita Karlova, vydavatelství Karolinum, 2022, 317 stran. ISBN 9788024651026. info
  • Green chemistry in drug discovery : from academia to industry. Edited by Paul F. Richardson. New York: Humana Press, 2022, xvi, 617. ISBN 9781071615775. info
  • The practice of medicinal chemistry. Edited by Camille Georges Wermuth - David Aldous - Pierre Raboisson - Didier Rog. Fourth edition. Amsterdam: Elsevier, 2015, 1 online. ISBN 9780124172135. URL info
  • DOLEŽAL, Martin. Farmaceutická chemie léčiv působících na centrální nervový systém. Vydání 1. Praha: Karolinum, 2013, 188 stran. ISBN 9788024623825. info
Teaching methods
Self-study, work with scientific and professional publications and personal consultations.
Assessment methods
oral examination
Language of instruction
English
The course is also listed under the following terms Spring 2025, Spring 2026.
  • Enrolment Statistics (Autumn 2025, recent)
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