FAIF1_14 Immunopharmacology

Faculty of Pharmacy
Spring 2020
Extent and Intensity
2/1/0. 4 credit(s). Type of Completion: zk (examination).
Teacher(s)
MUDr. PharmDr. Marek Frydrych, Ph.D. (lecturer)
MUDr. PharmDr. Marek Frydrych, Ph.D. (seminar tutor)
Guaranteed by
MUDr. PharmDr. Marek Frydrych, Ph.D.
Department of Pharmacology and Toxicology – Departments – Faculty of Pharmacy
Course Enrolment Limitations
The course is also offered to the students of the fields other than those the course is directly associated with.
fields of study / plans the course is directly associated with
Course objectives
Immunopharmacology focuses on the mechanism of action of pharmacologic agents that regulate immune response and on the physiologic, pathologic, and pharmacologic role of the products of immune response. Topics include cytokines and their use in therapy, immunosuppressive drugs, immunostimmulants, monoclonal antibodies, mechanisms and immunotherapy of allergic diseases, clinical transplantation, AIDS therapy, disease modifying anti-rheumatic drugs, drugs in the treatment of inflammatory bowel diseases and COPD. Each lecture is followed by a tutorial where clinical report cases to the corresponding topic will be discussed.
Syllabus
  • Syllabus of Lectures and Tutorials:
    1.Introduction to Immunopharmacology, Overview of the Immune Response, Hematopoiesis Including
    Lymphocyte Development and Maturation, T and B Cell Mediated Immunity, Cytokines, Innate and
    Acquired Immunity
    Tutorial: Inflammatory Mediators, Hypersensitivity and Autoimmunity, Cancer Immunity
    2.Cytokines I. Role of Cytokines, IL-1, IL-2, IL-4, IL-5, IL-6, IL-9, IL-10, IL-11, IL-13, IL-18,
    Therapeutic Use of IL-1,2,11
    Tutorial: Clinical Case Reports Related to the Topic
    3.Cytokines II. Interferons - Division and Clinical Applications, Colony Stimulating Factors -
    G-CSF, GM-CSF, TNF-alpha, Etanercept
    Tutorial: Clinical Case Reports Related to the Topic
    4.Immunosuppressive Drugs I. Glucocorticoids - Mechanism of Action, Absorption, Distribution and
    Excretion, Side Effects, Clinical Uses
    Tutorial: Clinical Case Reports Related to the Topic
    5.Immunosuppressive Drugs II. Cytotoxic Agents - Methotrexate, Cyclophosphamide, Azathioprine
    Tutorial: Clinical Case Reports Related to the Topic
    6.Immunosuppressive Drugs III. Cyclosporine, Tacrolimus, Sirolimus, Everolimus, Mycophenolate
    Mofetil, Fingolimod
    Tutorial: Clinical Case Reports Related to the Topic
    7.Immunostimmulants: Isoprinosine, Bacterial Extracts, Vaccines
    Tutorial: Clinical Case Reports Related to the Topic
    8.Monoclonal Antibodies as Therapeutic Agents in Tissue Transplantation, in the Treatment of
    Psoriasis, Rheumatoid Arthritis, Thrombosis and in the Treatment of Cancer
    Tutorial: Clinical Case Reports Related to the Topic
    9.Anti-Allergic Drugs: Chromones, Histamine Receptors Antagonists, Anti-IgE
    Tutorial: Clinical Case Reports Related to the Topic
    10.Drugs For the Treatment of Asthma and COPD: Bronchodilators (beta2-Agonists, Theophylline,
    Anticholinergics), Controller Drugs (Corticosteriods, Cromones, Mediator Antagonists:
    Anti-Histamines, Anti-Leukotrienes, Anti-IgE)
    Tutorial: Clinical Case Reports Related to the Topic
    11.Disease Modifying Anti-Rheumatic Drugs: Antimalarial Drugs, Sulphasalazine, Gold Complexes,
    Leflunomide, Monoclonal Antibodies in the Treatment of Rheumatiod Diseases
    Tutorial: Clinical Case Reports Related to the Topic
    12.Drugs For the Treatment of Inflammatory Bowel Diseases: Therapeutic Strategy, Aminosalicylates,
    Corticosteroids, Antibiotics, Immunosuppressive Agents, Anti-Cytokines
    Tutorial: Clinical Case Reports Related to the Topic
    13.Acquired Immune Deficiency Syndrome: HIV Disease, Clinical Strategy for the Treatment of AIDS -
    Reverse Transcriptase Inhibitors, Protease Inhibitors, Drugs Inhibiting Viral Binding, Drugs
    Stimulating Immune Response
    Tutorial: Clinical Case Reports Related to the Topic
    14.Tissue Transplantation: Types of Organ Rejection (Hyperacute, Acute, Chronic), GvHD, Clinical
    Transplantation (Kidney, Liver, Pancreas, Heart, Lung, Bone Marrow)
    Tutorial: Clinical Case Reports Related to the Topic
Literature
    required literature
  • Manzoor M. Khan. Immunopharmacology. Springer Science, 2008. ISBN 978-0-387-77975-1. info
    recommended literature
  • Nijkamp F. P., Parnham M. J. Principles of Immunopharmacology: 3rd revised and extended edition. Springer Science, 2011. ISBN 978-3-0346-0135-1. info
Language of instruction
English
Further Comments
The course can also be completed outside the examination period.
  • Enrolment Statistics (recent)
  • Permalink: https://is.muni.cz/course/pharm/spring2020/FAIF1_14