C5320 Theoretical Concepts of Nuclear Magnetic Resonance

Faculty of Science
Spring 2023
Extent and Intensity
2/0/0. 2 credit(s) (fasci plus compl plus > 4). Recommended Type of Completion: zk (examination). Other types of completion: k (colloquium).
prof. Mgr. Lukáš Žídek, Ph.D. (lecturer)
Mgr. Pavel Kadeřávek, Ph.D. (assistant)
Guaranteed by
prof. Mgr. Lukáš Žídek, Ph.D.
National Centre for Biomolecular Research - Faculty of Science
Supplier department: National Centre for Biomolecular Research - Faculty of Science
Course Enrolment Limitations
The course is also offered to the students of the fields other than those the course is directly associated with.
fields of study / plans the course is directly associated with
there are 9 fields of study the course is directly associated with, display
Course objectives
The course objective is to provide theoretical description of nuclear magnetic spectroscopy and to make the student familiar with the following areas of the NMR Theory: Theoretical concepts of classical description using the vector model as well as of quantum mechanics needed for proper understanding of multi-dimensional NMR techniques are discussed. The product operator formalism is introduced to facilitate description of basic one and two-dimensional experiments frequently used in chemical research.
Learning outcomes
At the end of the course, the students will be able to
1. understand theoretical description of NMR spectroscopy
2. understand principles of modern methods of NMR spectroscopy used in organic and inorganic chemistry, biochemistry, strucutural biology and biophysics.
3. select the method suitable for given application.
4. analyze basic NMR experiments at the level of the vector model and of the product operator formalism.
5. identify parameters determining results of the experiments.
  • 1. Magnetic moment in classical electromagnetism
  • 2. Nuclear magnetic resonance
  • 3. Relaxation
  • 4. Signal acquisition and processing
  • 5. Spin in quantum mechanics
  • 6. Mixed state of non-interacting spins
  • 7. Chemical shift, NMR experiment
  • 8. Product operators, dipolar coupling
  • 9. 2D spectroscopy, NOESY
  • 10. J-coupling, spin echoes
  • 11. INEPT, HSQC, APT
  • 12. COSY
    recommended literature
  • KEELER, James. Understanding NMR spectroscopy. Chichester: Wiley, 2005. xv, 459. ISBN 0470017872. URL info
  • LEVITT, Malcolm H. Spin dynamics : basics of nuclear magnetic resonance. 2nd ed. Hoboken, NJ: John Wiley & Sons, 2008. xxv, 714. ISBN 9780470511176. URL info
  • Protein NMR spectroscopyprinciples and practice. Edited by John Cavanagh. 2nd ed. Boston: Academic Press, 2007. xxv, 885 p. ISBN 012164491X. info
  • HOCH, Jeffrey C. and Alan S. STERN. NMR data processing. New York: Wiley-Liss, 1996. xi, 196. ISBN 0471039004. info
    not specified
  • BROWN, Keith C. Essential mathematics for NMR and MRI spectroscopists. Cambridge, UK: Royal Society of Chemistry, 2017. xvi, 867. ISBN 9781782627975. info
Teaching methods
Lectures, class discussion
Assessment methods
Oral examination
Language of instruction
Follow-Up Courses
Further Comments
Study Materials
The course can also be completed outside the examination period.
The course is taught annually.
The course is taught: every week.
The course is also listed under the following terms Autumn 2007 - for the purpose of the accreditation, Autumn 1999, Autumn 2010 - only for the accreditation, Autumn 2000, Autumn 2001, Autumn 2002, Autumn 2003, Autumn 2004, Autumn 2005, Autumn 2006, Autumn 2007, Autumn 2008, Autumn 2009, Autumn 2010, Autumn 2011, Autumn 2011 - acreditation, Autumn 2012, Autumn 2013, Autumn 2014, Autumn 2015, Autumn 2016, autumn 2017, Autumn 2018, Spring 2020, Spring 2021, Spring 2022.
  • Enrolment Statistics (recent)
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