PřF:C5320 Theoretical Concepts of NMR - Course Information
C5320 Theoretical Concepts of Nuclear Magnetic Resonance
Faculty of ScienceAutumn 2005
- Extent and Intensity
- 2/0/0. 2 credit(s) (fasci plus compl plus > 4). Recommended Type of Completion: zk (examination). Other types of completion: k (colloquium).
- Teacher(s)
- prof. RNDr. Vladimír Sklenář, DrSc. (lecturer)
- Guaranteed by
- prof. RNDr. Vladimír Sklenář, DrSc.
Chemistry Section – Faculty of Science - Timetable
- Wed 13:00–14:50 02004
- Course Enrolment Limitations
- The course is also offered to the students of the fields other than those the course is directly associated with.
- fields of study / plans the course is directly associated with
- there are 25 fields of study the course is directly associated with, display
- Course objectives
- Introduction to basic principles of NMR spectroscopy. Theoretical concepts of classical description using the vector model as well as of quantum mechanics needed for proper understanding of multi-dimensional NMR techniques are discussed. The product operator formalism is introduced to facilitate description of basic one and two-dimensional experiments frequently used in chemical research. The acquired knowledge enables students to understand the applications of NMR spectroscopy in organic and inorganic chemistry, biochemistry, strucutural biology and biophysics.
- Syllabus
- 1. Introduction: NMR history and contemporary trends - applications of NMR to strcutural studies in liquids and solids, NMR tomography, expected developments, tour of NMR lab at NCBR 2. Basic principles: magnetic dipol, resonance condition, NMR spectrometer, Fourier spectroscopy, classical description - Bloch equations, relaxation - spin-lattice and spin- spin relaxation, Fourier transform, sensitvity 3. Spin system dynamics: basic properties of nuclear spin system, density matrix theory, matrix representaion, operators, spin Hamiltonia in Hilbert representation, average Hamiltonian theory. 4. Product operator formalism: basic principles, terminology, evolution of product operators, Hamiltnian in product basis, composite rotations, observables. 5. 1D Fourier spectroscopy: excitation sequences, spin-echo - principles, measurements of relaxtion times, polarization trasnfer, INEPT, DEPT, composite pulses, homo- and hetronuclear decoupling, plus filed gradients. 6. 2D Fourier spectroscopy: basic principles, formal theory of 2D detection, coherence pathways. 7. Basic methods of 2D spectroscopy: chemical shift correlation - COSY, dipol-dipol correlation - NOESY, phase cycles,methods for homo- and heteronuclear spin systems, spectral editing. 8. NMR apllications for structure determination of biomacromolecules: proteins and nucleic acids, structural parameters: proton distance determination, dihedral angles mesurements, mathematical reconstruction of 3D structures.
- Literature
- HORE, P. J., J. A. JONES and Stephen WIMPERIS. NMR : the toolkit. Online. 1st pub. Oxford: Oxford University Press, 2000. 85 s. ISBN 0198504152. [citováno 2024-04-23] info
- HOCH, Jeffrey C. and Alan S. STERN. NMR data processing. Online. New York: Wiley-Liss, 1996. xi, 196. ISBN 0471039004. [citováno 2024-04-23] info
- Protein NMR spectroscopy principles and practice.. Online. San Diego: Academic Press, 1996. 587 s. ISBN 0121644901. [citováno 2024-04-23] info
- CAVANAGH, John and Wayne J. FAIRBROTHER. Protein NMR Spectroscopy. Principles and Practice. Online. San Diego: Academic Press, 1996. 587 pp. ISBN 0-12-164490-1. [citováno 2024-04-23] info
- EVANS, Jeremy N. S. Biomolecular NMR spectroscopy. Online. Oxford: Oxford University Press, 1995. xvi, 444 s. ISBN 0-19-854766-8. [citováno 2024-04-23] info
- VEN, Frank J. M. van de. Multidimensional NMR in Liquids :basic principles and experimental methods. Online. New York: VCH Publishers, 1995. 399 s. ISBN 1-56081-665-1. [citováno 2024-04-23] info
- RAHMAN, Atta-ur-. Solving problems with NMR spectroscopy. Online. Edited by Muhammad Iqbal Choudhary. San Diego: Academic Press, 1995. xvi, 430. ISBN 0120663201. [citováno 2024-04-23] info
- Two-dimensional NMR spectroscopy :applications for chemists and biochemists. Online. Edited by William R. Croasmun - Robert M. K. Carlson. 2nd ed. New York: VCH Publishers, 1994. xxii, 958. ISBN 1-56081-664-3. [citováno 2024-04-23] info
- SANDERS, Jeremy K. M. Modern NMR spectroscopy : a workbook of chemical problems. Online. 2nd ed. Oxford: Oxford University Press, 1993. 127 s. ISBN 0198558120. [citováno 2024-04-23] info
- NMR of macromolecules : a practical approach. Online. Edited by Gordon C.K. Roberts. Oxford: Oxford University Press, 1993. 399 s. ISBN 0-19-963224-3. [citováno 2024-04-23] info
- RAHMAN, Atta-ur-. One and Two Dimensional NMR Spectroscopy. Online. 1. vyd. Amsterdam: Elsevier Science Publishers B.V., 1989. 578 s. ISBN 0444873163. [citováno 2024-04-23] info
- SCHRAML, Jan. Dvourozměrná NMR spektroskopie. Online. 1. vyd. Praha: Academia, 1987. 130 s. [citováno 2024-04-23] info
- GOLJER, Igor and Tibor LIPTAJ. Nové metódy FT NMR spektroskopie kvapalín. Online. 1. vyd. Bratislava: VEDA vydavatel'stvo Slovenskej akadémie vied, 1986. 181 s. [citováno 2024-04-23] info
- NMR and the periodic table. Online. Edited by Robin Kingsley Harris - Brian E. Mann. London: Academic Press, 1978. 459 s. ISBN 0123276500. [citováno 2024-04-23] info
- Language of instruction
- Czech
- Further Comments
- Study Materials
The course can also be completed outside the examination period.
The course is taught annually.
- Enrolment Statistics (Autumn 2005, recent)
- Permalink: https://is.muni.cz/course/sci/autumn2005/C5320