Bi7056 Development and production of vaccines and antivirals

Faculty of Science
Autumn 2024
Extent and Intensity
2/0/0. 4 credit(s). Type of Completion: zk (examination).
Taught in person.
Teacher(s)
PharmDr. Jakub Treml, Ph.D. (lecturer)
Guaranteed by
PharmDr. Jakub Treml, Ph.D.
Department of Experimental Biology – Biology Section – Faculty of Science
Contact Person: Mgr. et Mgr. Michal Dvořák
Supplier department: Department of Experimental Biology – Biology Section – Faculty of Science
Prerequisites
Bi5420 General virology && Bi4020 Molecular biology && Bi4090 General microbiology && Bi5220 Immunology
The lectures are held for students of biological disciplines, especially for virology students.
Course Enrolment Limitations
The course is also offered to the students of the fields other than those the course is directly associated with.
fields of study / plans the course is directly associated with
Course objectives
The aim of the course is to provide candidates with basic knowledge about the production, requirements, types, advantages and disadvantages of vaccines; present the process of developing new drugs within clinical trials; familiarize them with the basic reactions of the immune system; interpret the meaning and course of immunization and eradication of selected diseases, including COVID-19, describe the vaccination plan in the Czech Republic.
Learning outcomes
Upon successful completion of the course, the graduate will be able to describe and define vaccines, characterize and evaluate individual types of vaccines, advantages/disadvantages, requirements, routes of administration. The graduate will gain knowledge about the basics of production, the validation process and the production of vaccines. He will be able to describe the basic reactions of the immune system and interpret the meaning and principle of prevention of selected diseases. The graduate will get to know the development from the chemical structure to the drug and understand the individual phases of clinical studies, methodology and procedures applied in clinical testing and putting the drug/antiviral into practice.
The graduate will be able to apply knowledge in the production and development of antivirals and vaccines in the field of applied research, clinical studies, immunization in healthcare and the pharmaceutical industry.
Syllabus
  • General introduction to medicinal products and vaccines (with respect to antivirals), types of medicinal products.
  • From chemical structure to drug – preclinical research, four phases of clinical testing, ethics.
  • Clinical trial methodology - controlled, cohort studies, case studies, site selection, regulation. Vaccine production.
  • Immune system - defense against viruses, about the immune system in general, natural and adaptive immunity.
  • Vaccines - general requirements, advantages, disadvantages, obstacles in connection with vaccines.
  • Vaccines - types of vaccines, routes of administration, production of vaccines. Vaccines - disease eradication - smallpox, hepatitis B, success criteria.
  • Therapy and prevention of selected diseases, e.g. hepatitis A, HPV, influenza and others.
  • Global immunization - WHO recommendations, position and strategy.
  • COVID-19 - vaccines, strategies, current data.
  • Immunization in the Czech Republic - compulsory vaccination of children and adults.
Literature
    recommended literature
  • SHAMLEY, Delva and Brenda WRIGHT. A Comprehensive and Practical Guide to Clinical Trials. 1st ed. Cambridge, Massachusetts: Academic Press, 2017, 196 pp. ISBN 978-0-12-804729-3. info
  • BLOOM, Barry R. and Paul-Henri LAMBERT. The vaccine book. 2nd ed. Cambridge, Massachusetts: Academic Press, 2016, 610 pp. ISBN 978-0-12-802174-3. info
  • FIELDS, Bernard N. Fields virology. Edited by David M. Knipe - Peter M. Howley. 6th ed. Philadelphia: Lippincott Williams & Wilkins, 2013, xx, 1282. ISBN 9781451105636. info
  • CARTER, John B. and Venetia A. SAUNDERS. Virology : principles and applications. 2nd ed. Chichester: Wiley, 2013, xxix, 364. ISBN 9781119991434. info
Teaching methods
Teaching takes place in the form of lectures - Powerpoint presentations.
Assessment methods
The course ends with a written exam consisting of test and fill-in questions. A minimum of 60% of points is required to successfully complete the course.
Language of instruction
Czech
Further Comments
The course is taught annually.
The course is taught: every week.
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