Bi7055 Principles of Antiviral Therapy

Faculty of Science
Spring 2025
Extent and Intensity
2/0/0. 4 credit(s). Type of Completion: zk (examination).
Taught in person.
Teacher(s)
PharmDr. Jakub Treml, Ph.D. (lecturer)
Guaranteed by
PharmDr. Jakub Treml, Ph.D.
Department of Experimental Biology – Biology Section – Faculty of Science
Contact Person: Mgr. et Mgr. Michal Dvořák
Supplier department: Department of Experimental Biology – Biology Section – Faculty of Science
Prerequisites
Bi5420 General virology && Bi4020 Molecular biology && Bi4090 General microbiology && Bi5220 Immunology
The lectures are held for students of biological disciplines, especially for virology students.
Course Enrolment Limitations
The course is also offered to the students of the fields other than those the course is directly associated with.
fields of study / plans the course is directly associated with
Course objectives
The aim of the subject is to provide applicants with basic knowledge about drugs and medicinal products from the group of antivirals; explain the concepts of pharmacokinetics and pharmacodynamics; describe the development, mechanisms of action and clinical use of antivirals against individual types of viral diseases; explain the emergence of resistance to therapy and methods of activity testing; describe antivirals of natural origin.
Learning outcomes
Upon successful completion of the course, the graduate will be able to describe and define drugs and medicinal preparations. The graduate will gain knowledge about the basics of pharmacokinetics and pharmacodynamics, will be able to describe the mechanisms of action and the use of antivirals against selected viral diseases, and will understand the molecular principles of viral resistance to antiviral drugs. The graduate will be able to apply knowledge in the testing and development of antivirals in the field of applied research, clinical studies and the pharmaceutical industry.
Syllabus
  • General introduction to drugs and medicinal products (with regard to antivirals) - definitions, law on medicinal products, etc.
  • Pharmacokinetics, pharmacodynamics.
  • Laboratory diagnostics of viral diseases - sampling, direct and indirect diagnostics.
  • Antiretroviral drugs - drugs in the therapy of HIV infection.
  • Antivirals to treat the flu.
  • Antivirals for the treatment of herpes infections - types of herpes viruses, drugs.
  • Antivirals for the treatment of hepatitis.
  • Antivirals against SARS-CoV-2.
  • Antivirals against emerging viruses with special attention to flaviviruses.
  • Resistance in antiviral therapy. Natural substances in the therapy of viral diseases.
  • Methods of testing the antiviral activity and toxicity of drugs.
Literature
    recommended literature
  • FIELDS, Bernard N. Fields virology. Edited by David M. Knipe - Peter M. Howley. 6th ed. Philadelphia: Lippincott Williams & Wilkins, 2013, xx, 1282. ISBN 9781451105636. info
  • CARTER, John B. and Venetia A. SAUNDERS. Virology : principles and applications. 2nd ed. Chichester: Wiley, 2013, xxix, 364. ISBN 9781119991434. info
  • Hugo and Russell's pharmaceutical microbiology. Edited by S. P. Denyer - W. B. Hugo. 8th ed. Hoboken, N.J.: Wiley-Blackwell, 2011, x, 513 p. ISBN 9781118293836. info
  • HOLÝ, Antonín. Principy bioorganické chemie ve vývoji antivirotik a cytostatik. 1. vyd. Olomouc: Univerzita Palackého v Olomouci, 2004, 414 s. ISBN 8024408554. info
Teaching methods
Teaching takes place in the form of lectures - Powerpoint presentations.
Assessment methods
The course ends with a written exam consisting of test and fill-in questions. A minimum of 60% of points is required to successfully complete the course.
Language of instruction
Czech
Further Comments
The course is taught annually.
The course is taught: every week.
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