aFAAC1_15 General and Inorganic Chemistry

Farmaceutická fakulta
podzim 2025
Rozsah
3/2/0. 42p+28c. 6 kr. Ukončení: zk.
Vyučující
PharmDr. Tomáš Goněc, Ph.D. (přednášející)
Mgr. Aleš Kroutil, Ph.D. (přednášející)
Mgr. Aleš Kroutil, Ph.D. (cvičící)
Ing. Eliška Růžičková (pomocník)
Garance
PharmDr. Tomáš Goněc, Ph.D.
Ústav chemických léčiv – Ústavy – Farmaceutická fakulta
Rozvrh
Po 14:00–16:30 44-249
  • Rozvrh seminárních/paralelních skupin:
aFAAC1_15/01: Po 12:00–13:40 44-342, A. Kroutil
Omezení zápisu do předmětu
Předmět je určen pouze studentům mateřských oborů.
Mateřské obory/plány
Cíle předmětu
The students will be acquainted with the subject of chemistry including the basic branches of chemistry and the importance of chemistry for pharmacists. The course will focus on the following items: fundamental chemical terms and laws, equations for calculating the quantity of substance and concentration, atomic structure, radioactivity, basic equations used in spectral analysis, models of atomic orbitals, chemical bond including hybridization, physical states of matter, the periodic law and the classification of elements including forms and the division of the periodic system into groups, and the properties of individual elements in the periodic table.
Seminars will concentrate on problems such as nomenclature, formation of chemical formulas and balancing equations for stoichiometric calculations, and the calculation of the pH. During practical exercises, the students will be acquainted with the basics of laboratory work and will also prepare some inorganic compounds according to calculated equations. The students will elaborate protocols containing the description of the principle of the method and all calculations including the calculation of theoretical yield which will be compared with the practical yield obtained.
Výstupy z učení
After completing the course student will:
-know basic chemical glassware,equipment and apparatus;
-be able to perform basic laboratory operations independently;
-know inorganic compound nomenclature and basic chemical calculations;
-understand the basic principles of general chemistry;
-know basic chemistry of elements
Osnova
Lectures:
General Chemistry.
Mass, discreetness of particles. Elements, symbols, periodic table, molecule, chemical formula, chemical equation. Structure and electron formula, octet rule, hypervalence, resonance, oxidation state, formal charge. Electronegativity. Definition of element, nuclide, isotope. Atomic number, atomic mass, molecular mass, amount of mass, mol. Atom, nucleus, elemental particles of mass. Moseley rule. Radioactivity, natural and artificial radionuclides, nuclear reactions, decay families.
Quantum and wave theory, wave and particle, interference and difraction. Schrödinger equation. Planetar atom model, electron shell, Bohr model of hydrogen atom, line and continual spectra, therms, hydrogen spectrum. Structure of electron shell, quantum nombers, Pauli rule, Hund rule, stable valence shell configuration, excited state, electron configuration writing. Mendelejev periodic rule. Ionization potential, electron affinity, electronegativity. Atomic orbitals.
Chemical bond, forms of bonding, bonding energy. Covalent bond. Valence bonding theory, simple and multiple bonds. VSEPR. Hybridization.
Molecule orbitals theory (MO) - linear combination of atomic orbitals (LCAO), energetic diagram. MO for: H2, N2, O2 and O3. Delocalized bonds, polarised bond. System of bonds in ethene, ethyne, benzene and allene.
Hydrogen bonds, other weak interactions. Ionization, basic ion properties, ionic bond. Crystals. Metalic bond. Electron conductivity. Donor-acceptor bond, ions of transition metals, coordinational reactions, sorts of ligands and their properties. Coordination bonding theory. Structure, magnetic properties.
Chemical ballance, basic thermodynamical and thermochemical laws, state equations. Entalpy, entropy, free energy, spontaneousness of processes. Floating ballance principle. Basics of chemical kinetics. Speed and order of reaction. Activation energy. Arrhenius equation. Catalysis. Radical reactions. Photochemical reactions. State definitions. State of matter, dispersion systems. Solubility, solutions, concentration, diffusion, osmosis.
Base and acid theories, protolytic reactions, neutralisation, salts, strenght of acid and base, pH, indicators, salts hydrolysis, buffers. Lewis theory, electrophiles and nucleophiles. Coagulation. Factor of solubility. Reduction-oxidation reactions. Ballancing of red-ox equations. Electrode processes. Electrochemical potential.
Inorganic chemistry.
Chemistry of hydrogen, water. Alkalic metals, metals of alkaline earths.
P elements, Halogens, Noble gases. Transition elements.
Inorganic compounds important in biosystems and pharmacy.
Practical class
- Introduction to laboratory work
- Distillation and extraction
- Synthesis of trihydrogen boric acid.
- Synthesis of disodium tetrahydroxo pentaoxoborate.
- Synthesis of lead iodide.
- Benzoic acid purification
- Preparation od copper and ferrous sulphate pentahydrate.
- Coordination compounds, hydroxides - test tube reactions

Literatura
    doporučená literatura
  • PFAFF, Gerhard. Inorganic pigments. 2nd, revised and extended ed. Berlin: De Gruyter, 2023, xi, 379. ISBN 9783110743913. info
  • TIMBERLAKE, Karen C. Chemistry : an introduction to general, organic, and biological chemistry. Global edition. New York: Pearson, 2019, 716 stran. ISBN 9781292228860. info
  • HOUSECROFT, Catherine E. a A. G. SHARPE. Inorganic chemistry. 4th ed. Harlow: Pearson, 2012, xl, 1213. ISBN 9780273742753. info
  • Greenwood N.N., Earnshaw A. Chemistry of the Elements. Amsterdam, Elsevier, 2010. ISBN 9780750633659. info
Výukové metody
Lectures, laboratory classes
Metody hodnocení
To obtain credits, it is necessary to meet the following conditions: compulsory participation in laboratory classes, the obligation to prepare protocols from all practical tasks. Success in continuous tests in nomenclature and calculations at least 60%. Completion of the written exam in nomenclature, general chemistry and inorganic chemistry to at least 60%.
Vyučovací jazyk
Angličtina
Informace učitele
Course evaluation.
The course consists of lectures and exercises. 6 credits can be obtained for the course under the following conditions:
1. successfull completion of seminars and exercises
Attendance at all seminars and exercises is compulsory.
Absence from seminars and exercises must be documented by a reliable medical certificate.
In case of another reason for absence, the student will replace the exercise in the last week.
Protocols are handed in from the exercises, which are either accepted by the teachers after checking, or returned for completion. Acceptance of all protocols is a condition for admission to the exam.
Part of the exercises are continuous tests on terminology, calculations and formulas. The condition for admission to the exam is an average of at least 60% success in all tests.
2. successfull completion of written exam on nomenclature, general chemistry and inorganic chemistry
Evaluation of the written exam:
A( 1 ) 92-100%
B( 1-) 84-91%
C( 2 ) 76-83%
D( 2-) 68-75%
E( 3 ) 60-67%
F <60 %
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