FDALa_FAF Analysis of Pharmaceuticals

Farmaceutická fakulta
podzim 2025
Rozsah
2/0/0. 5 kr. Ukončení: zk.
Vyučováno kontaktně
Vyučující
doc. PharmDr. Ing. Radka Opatřilová, Ph.D., MBA (přednášející)
Garance
doc. PharmDr. Ing. Radka Opatřilová, Ph.D., MBA
Farmaceutická fakulta
Dodavatelské pracoviště: Ústav chemických léčiv – Ústavy – Farmaceutická fakulta
Předpoklady
Basics of analytical chemistry and chemical properties of drugs
Omezení zápisu do předmětu
Předmět je určen pouze studentům mateřských oborů.
Mateřské obory/plány
Cíle předmětu
The aim of the course is to deepen students' knowledge of methods of work and possibilities of application of methods of analytical chemistry for the field of drug analysis. The main emphasis is placed on the analysis of drugs, which is directly related to the thematic focus of the student's dissertation. The student is guided to master the entire analytical system from sampling to analytical interpretation of results, including the use of relevant statistical methods.
Výstupy z učení
Learning outcomes of the course are theoretical knowledge and practical experience of students of methods used for comprehensive evaluation of drugs and medicinal products in accordance with applicable regulations in the Czech Republic and the EU. The content of the course is based on the requirements of the European Pharmacopoeia as a supranational legal norm. The graduate of the course Drug Analysis is to master the basic procedures and methods of pharmacopoeial evaluation of drugs. Evidence of drugs based on physical constants, using instrumental-analytical methods and chemical reactions. To control group and selective reactions of structural types of drugs within pharmacotherapeutic groups. He has mastered the technique of limit tests for the purity of drugs, volumetric and gravimetric determination of drugs and pharmaceutical excipients. He should be able to perform analytical evaluation of drugs and medicinal products using chromatographic, spectral and electroanalytical methods. He should be able to perform experimental studies of medicinal products, evaluation of relevant physical and chemical parameters, including detection and quantification of degradation products, according to the given procedure.
Osnova
Drug Identification and Drug Assay:
- detection and quantification of drugs on the basis of physical constants (melting point, distillation range, density, refractive index, optical rotation),
- detection and quantification of drugs using of physicochemical methods (spectral, separational, electrochemical methods),
Purity and stability of drugs
Literatura
    doporučená literatura
  • European Pharmacopoeia. https://pheur.edqm.eu/home
  • Český lékopis 2023. Praha: Grada, 2023.
  • Modern aspects of pharmaceutical quality assurance : developing & proposing application models, SOPs, practical audit systems for pharma industry. Edited by Minal Ghante - Manohar Potdar - Vidhya Bhusari. Singapore: Springer, 2024, 1 online. ISBN 9789819992713. URL info
  • ČULEN, Martin; Jiří DOHNAL a JAMPÍLEK. Selected Analytical Techniques of Solid State, Structure Identification, and Dissolution Testing in Drug Life Cycle. Analytical Techniques in Drug Life Cycle. Online. 1., elektronické vyd. Brno: Masarykova univerzita, 2022. ISBN 978-80-280-0193-3. Dostupné z: https://doi.org/10.5817/CZ.MUNI.O280-0193-2022. Čítárna Munispace info
  • WATSON, David G. a Bhavik A. PATEL. Pharmaceutical analysis : a textbook for pharmacy students and pharmaceutical chemists. Fifth edition. Edinburgh: Elsevier, 2021, vi, 462. ISBN 978070208088. info
  • ASHUTOSH KAR. Pharmaceutical Drug Analysis. New Age International (P) Ltd., Publishers, 2005. ISBN 9788122427189. info
Výukové metody
theoretical training, individual consultations, discussion
Metody hodnocení
oral exam
Vyučovací jazyk
Angličtina
Informace učitele
Teaching takes the form of personal consultations and other educational activities, that are recommended by the guarantor of the course. The course is done using self-studies. Practical application of acquired knowledge assists you in attaining the exact techniques for your doctoral thesis.
Předmět je zařazen také v obdobích jaro 2025, jaro 2026.
  • Statistika zápisu (nejnovější)
  • Permalink: https://is.muni.cz/predmet/pharm/podzim2025/FDALa_FAF