FDOCa_FAF Organic Chemistry

Farmaceutická fakulta
podzim 2025
Rozsah
2/0/0. 5 kr. Ukončení: zk.
Vyučováno kontaktně
Vyučující
doc. Ing. Pavel Bobáľ, CSc. (přednášející)
Garance
doc. Ing. Pavel Bobáľ, CSc.
Farmaceutická fakulta
Dodavatelské pracoviště: Ústav chemických léčiv – Ústavy – Farmaceutická fakulta
Omezení zápisu do předmětu
Předmět je určen pouze studentům mateřských oborů.
Mateřské obory/plány
Cíle předmětu
Organic chemistry gives students information about the fundamentals of organic compounds structure, their reactions, and the underlying reaction mechanism. Organic chemistry is essential for many other disciplines, such as biochemistry, analytical chemistry, pharmaceutical chemistry, physiology, pharmacology and other health and biological studies. Close attention is paid to the interrelation between organic chemistry and these disciplines.
Výstupy z učení
Understanding of organic chemistry, understanding of structure and reactivity of organic compounds, knowledge of the basis of IUPAC nomenclature of organic compounds and principals of stereochemistry.
Osnova
1. What is organic chemistry?
2. Organic structures
3. Determining organic structures
4. Structure of molecules
5. Organic reactions
6. Nucleophilic addition to the carbonyl group
7. Delocalization and conjugation
8. Acidity, basicity, and pKa
9. Using organometallic reagents to make C-C bonds
10. Nucleophilic substitution at the carbonyl group
11. Nucleophilic substitution at C=O with loss of carbonyl oxygen
12. Equilibria, rates, and mechanisms
13. 1H NMR: Proton nuclear magnetic resonance
14. Stereochemistry
15. Nucleophilic substitution at saturated carbon
16. Conformational analysis
17. Elimination reactions
18. Review of spectroscopic methods
19. Electrophilic addition to alkenes
20. Formation and reactions of enols and enolates
21. Electrophilic aromatic substitution
22. Conjugate addition and nucleophilic aromatic substitution
23. Chemoselectivity and protecting groups
24. Regioselectivity
25. Alkylation of enolates
26. Reactions of enolates with carbonyl compounds: the aldol and Claisen
reactions
27. Sulfur, silicon, and phosphorus in organic chemistry
28. Retrosynthetic analysis
29. Aromatic heterocycles 1: reactions
30. Aromatic heterocycles 2: synthesis
31. Saturated heterocycles and stereoelectronics
32. Stereoselectivity in cyclic molecules
33. Diastereoselectivity
34. Pericyclic reactions 1: cycloadditions
35. Pericyclic reactions 2: sigmatropic and electrocyclic reactions
36. Participation, rearrangement, and fragmentation
37. Radical reactions
38. Synthesis and reactions of carbenes
39. Determining reaction mechanisms
40. Organometallic chemistry
41. Asymmetric synthesis
42. Organic chemistry of life
43. Organic chemistry today
Literatura
    povinná literatura
  • MCMURRY, John. Organická chemie. Vydání první. Brno: Vysoké učení technické v Brně/Nakladatelství VUTIUM, 2015, xix, 1178. ISBN 9788070809303. info
    doporučená literatura
  • TIMBERLAKE, Karen C. Chemistry : an introduction to general, organic, and biological chemistry. Global edition. New York: Pearson, 2019, 716 stran. ISBN 9781292228860. info
  • VOGEL, Pierre a Kendall N. HOUK. Organic chemistry : theory, reactivity and mechanisms in modern synthesis. Edited by Robert H. Grubbs. Weinheim: Wiley-VCH, 2019, xxx, 1352. ISBN 9783527345328. info
  • KLEIN, David R. Organic chemistry. Global edition. Singapore: Wiley, 2018, xvi, 1217. ISBN 9781119451051. info
Výukové metody
consutations, discussions, individual work and reading
Metody hodnocení
Oral examination
Vyučovací jazyk
Angličtina
Předmět je zařazen také v obdobích jaro 2025, jaro 2026.
  • Statistika zápisu (nejnovější)
  • Permalink: https://is.muni.cz/predmet/pharm/podzim2025/FDOCa_FAF