aFAFC1_14 Human Physiology and Pathophysiology I

Farmaceutická fakulta
jaro 2026
Rozsah
2/1/0. 28p+14c. 3 kr. Ukončení: z.
Vyučující
MVDr. Jana Doležalová, Ph.D. (přednášející)
MUDr. Marta Chalupová, Ph.D. (přednášející)
PharmDr. Mgr. Alžběta Kružicová, Ph.D. (přednášející)
MUDr. Tomáš Parák, Ph.D. (přednášející)
PharmDr. Lenka Paráková, Ph.D. (přednášející)
MVDr. Lada Tlučhořová (přednášející)
MVDr. Jana Doležalová, Ph.D. (cvičící)
MUDr. Marta Chalupová, Ph.D. (cvičící)
PharmDr. Mgr. Alžběta Kružicová, Ph.D. (cvičící)
MUDr. Tomáš Parák, Ph.D. (cvičící)
PharmDr. Lenka Paráková, Ph.D. (cvičící)
MVDr. Lada Tlučhořová (cvičící)
Mgr. Noemi Arači (cvičící)
Mgr. Noemi Arači (náhr. zkoušející)
Garance
MUDr. Tomáš Parák, Ph.D.
Ústav farmakologie a toxikologie – Ústavy – Farmaceutická fakulta
Rozvrh
Po 13:00–14:40 44-247, kromě Po 27. 4. ; a Po 4. 5. 14:40–16:20 44-247
  • Rozvrh seminárních/paralelních skupin:
aFAFC1_14/01: každé liché pondělí 14:40–16:20 44-247, kromě Po 4. 5. ; a Po 27. 4. 13:00–14:40 44-247, J. Doležalová, M. Chalupová, A. Kružicová, T. Parák, L. Paráková, L. Tlučhořová
Omezení zápisu do předmětu
Předmět je určen pouze studentům mateřských oborů.
Mateřské obory/plány
Anotace
Human physiology is defined as a science of the functions of healthy organism at the level of cell, tissue, organ and organ systems. Pathophysiology is focused on etiopathogenesis - the mechanisms which lead from the primary cause via individual malfunctions to subsequent development of clinical symptoms of disease. Knowledge of these mechanisms serves to develop a suitable and efficient therapy and prevent resultant damage.
Výstupy z učení
After completing the course, the student will be able to:
- describe the physiology and pathophysiology of the main organs
- recognize subjective and objective symptoms of diseases
- examine the main physiological functions
- interpret examination results
Klíčová témata
PHYSIOLOGY AND PATHOPHYSIOLOGY I - LECTURES:
1. Introduction into pathophysiology, symptoms of diseases and their diagnosing. Disease development. Genetic factors in pathogenesis.
2. General physiological principles. Cell physiology. Function of cell membrane and intracellular structures. Basic principles of physiological regulation.
3. Nonspecific defence mechanisms. Inflammation. Stress. Damage of organism (physical, chemical and biological)
4. Specific defensive mechanisms and their disorders. Cell-mediated and antibody immunity. White blood cells, functions and disorders.
5. Physiology of the locomotive apparatus. Most common diseases of bones, muscles and joints. Inflammatory and degenerative rheumatic diseases.
6. Physiology of digestion and absorption, metabolism of sacharides, fats and proteins. Nutritional disorders, obesity and starving. Metabolic syndrome.
7. Vitamins, mineral substances and trace elements. Hyper and hypovitaminoses. Diseases of deficiency and excess of mineral substances and trace elements.
8. Physiology of blood formation. Differential diagnosing of anaemia.
9. Hemostasis and hemocoagulation. Coagulation cascade and its disorders. Hemorrhagic and hypercoagulable states.
10. Physiology of the circulatory system. Formation and development of atherosclerosis. Ischemic heart disease.
11. Formation and transmission of excitement and its disorders. Inherited and acquired heart disorders.
12. Basic principles of the blood pressure regulation. Hypertensive disease. Hypotension. Circulation failure (shock).
13. Theory of the formation of malignant growth. Tumours and their classification. Overview of clinically most common cancers.

Syllabus of exercises:
I. Basic physiological functions and their watching
1. Anamnesis, interview
2. Objective and subjective anamnesis
3. Basic checkup (examinations)
II. Cardiovascular system
1. Auscultation of heart sounds
2. Measurement of blood pressure
3. Electrocardiography
III. Respiratory system
1. Auscultation of lungs
2. Spirometry, Pulse oxymetry
3. Basal metabolism
IV. Nervous system
1. Hearing tests
2. Eye tests
3. Optical illusions
4. EEG
V. Urogenital tract, diabetes mellitus
1. Semi-quantitative urinalysis
2. Specific weight of urine
3. Kidney functions
4. Menstrual cycle, ovulation, gravidity
VI. Blood, Good laboratory practice
1. Red blood cells
2. Blood count
3. Haematocrit
4. Erythrocyte sedimentation
5. Differential leukocytes count

VII. Obtaining credits
Studijní zdroje a literatura
    doporučená literatura
  • GRANT, Allison. Ross & Wilson pathophysiology. [London]: Elsevier, 2024, vii, 408. ISBN 9780702077715. info
  • SILBERNAGL, Stefan a Florian LANG. Color atlas of pathophysiology. 3rd edition. Stuttgart: Thieme, 2016, x, 438. ISBN 9783131165534. info
  • MCCANCE, Kathryn L. a Sue E. HUETHER. Pathophysiology : the biologic basis for disease in adults and children. Edited by Valentina L. Brashers - Neal S. Rote. Seventh edition. St. Louis: Elsevier, 2014, xxvi, 1810. ISBN 9780323088541. info
Přístupy, postupy a metody používané ve výuce
Lectures, seminars, exercises, exercises in selected examination techniques, consultations
Způsob ověření výstupů z učení a požadavky na ukončení
To gain credits: Data analysis, eventualyy seminar papers on given topics, written test or an oral exam.
Vyučovací jazyk
Angličtina
Odkaz a informace vyučujících
Participation at seminars and excercises 100% and knowledge of recomended literature in the extent of lectures, seminars and excercises of this course are reqired. Without recognition the course or granting the credits is not possible to continue the following course Human Physiology and Pathophysiology II.
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  • Statistika zápisu (nejnovější)
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