aFANM1_15 NMR Structural Analysis of Organic Compounds

Farmaceutická fakulta
podzim 2025

Předmět se v období podzim 2025 nevypisuje.

Rozsah
0/2/0. 28s. 3 kr. Ukončení: zk.
Vyučující
PharmDr. Jan Otevřel, Ph.D. (přednášející)
Mgr. David Švestka, Ph.D. (cvičící)
Garance
PharmDr. Jan Otevřel, Ph.D.
Ústav chemických léčiv – Ústavy – Farmaceutická fakulta
Omezení zápisu do předmětu
Předmět je určen pouze studentům mateřských oborů.
Mateřské obory/plány
Cíle předmětu
The subject aims to acquaint students not only with the theoretical foundations of nuclear magnetic resonance, but above all with the practical interpretation of measured spectra. The acquired knowledge will enable students to independently process and analyze spectra obtained using NMR and determine the structure of organic compounds based on these spectra.
Výstupy z učení
After completing the course, the student is able to explain the theoretical foundations of NMR spectroscopy, process and interpret NMR spectra (mainly 1H, 13C, 19F, 31P), orientate themselves in the basic issues of 2D NMR spectra, confirm or derive the resulting structure of organic substances from the presented spectra.
Osnova
  • 1. Theoretical foundations of NMR, signal generation, types of nuclear interactions, chemical shift, interaction constant
  • 2. Construction of spectrometers, sample preparation and measurement, solvents used in  NMR, computer programs used to process NMR spectra
  • 3. Symmetry of molecules and chemical equivalence of nuclei, magnetic equivalence of nuclei, effects on chemical shift
  • 4. Formation of multiplets, notation of spin systems, analysis of simple spin systems.
  • 5. Analysis of more complex spin systems and multiplets, dynamic processes in  NMR
  • 6. Interpretation and recording of 1H NMR spectra
  • 7. Specifics of 13C NMR, interpretation and recording of 13C NMR, decaplink, multipulse experiments (APT, ...)
  • 8. Specificity of 19F, 31P and other elements in NMR, interpretation and recording of 19F NMR
  • 9. Tasks to practice the interpretation of spectra
  • 10. Homo- and heteronuclear 2D NMR experiments
  • 11. Tasks to practice the interpretation of spectra
  • 12. NMR as a tool for quantitative analysis
Literatura
    doporučená literatura
  • SILVERSTEIN, Robert M. Spectrometric identification of organic compounds. 8th ed. Hoboken: Wiley,, 2015. ISBN 978-0-470-61637-6. info
Výukové metody
seminars, class discussion, work with PC applications and laboratory tools
Metody hodnocení
Attending the seminars, submitting the individual assignments. Final examination - oral and practical part.
Vyučovací jazyk
Angličtina
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