C6210 Biotechnology

Faculty of Science
spring 2018
Extent and Intensity
2/0/0. 2 credit(s) (fasci plus compl plus > 4). Type of Completion: zk (examination).
Teacher(s)
doc. Ing. Martin Mandl, CSc. (lecturer)
Supervisor
doc. Ing. Martin Mandl, CSc.
Department of Biochemistry - Chemistry Section - Faculty of Science
Contact Person: doc. Ing. Martin Mandl, CSc.
Supplier department: Department of Biochemistry - Chemistry Section - Faculty of Science
Prerequisites
( Bi1700 Cell Biology || C7920 Struct. and func. of proteins || CG010 Proteomics || C1470 Introduction to mathematics for chemoinformatics and bioinformatics || SOUHLAS ) && ! NOWANY ( C6211 Biotechnology )
Basic knowledge of biochemistry and cell biology.
Course Enrolment Limitations
The course is offered to students of any study field.
Course objectives
The goals are biochemical principles of traditional and recent biotechnologies and fundamental processes in fermenters and other apparatuses which provide the biotechnological use of metabolic activity of organisms or enzymes.
Learning outcomes
Students will be able:
-to be knowledgeable about biochemistry and physiology of organisms in relation to their use in biotechnology;
-to know principles of selected fermentation processes and application of biotechnology to environmental protection;
-to understand basic biotechnological operations and processes taking part in bioreactors of various construction;
-to understand fundamental knowledge of microbial kinetics.
Syllabus
  • Microbial and enzyme biotechnology, historical survey. Biochemistry, microbiology and engineering principles.
  • Biochemical and chemical principles of classical and recent biotechnologies. Beer, wine and organic acid production.
  • Microbial biomass production as a protein supply, biomining, biomedicine).
  • Environmental biotechnology. Bioremediation (heavy metals, hydrocarbons), biogas, biofuels, algae biotechnology, bioelectricity).
  • Cultivation and production bioreactors, scale-up. Agitation in fermenters, the impact on metabolic activity of organisms.
  • Aeration in bioprocesses. Oxygen transfer.
  • Determination of the mass-transfer oxygen coefficient. Aeration parameters in bioreactors in relation to oxygen demand by production cultures and enzymes, scale-up.
  • Batch culture. Growth and production kinetics. Models of substrate utilization and product formation.
  • Cell growth and death kinetics. Kinetic models in biotechnology and microbial (cell) physiology, the model selection.
  • Continuous culture. Determination of kinetic and physiological parameters in a chemostat. The relationship with the batch culture.
  • Immobilised cells and enzymes, principles and applications.
  • Bioreactors based on immobilised cells and enzymes.
Literature
    recommended literature
  • KAŠTÁNEK, František. Bioinženýrství. Vyd. 1. Praha: Academia, 2001. 334 s. ISBN 8020007687. info
  • STANBURY, Peter F., Allan WHITAKER and Stephen J. HALL. Principles of fermentation technology. 2nd ed. Oxford: Pergamon, 1995. xviii, 357. ISBN 0-08-036131-5. info
  • DORAN, Pauline M. Bioprocess engineering principles. London: Academic Press, 1995. xiv, 439 s. ISBN 0-12-220856-0. info
  • KRUMPHANZL, Vladimír and Zdeněk ŘEHÁČEK. Mikrobiální technologie : buňka a techniky jejího využití. 1. vyd. Praha: Academia, 1988. 360 s., 24. info
  • ALEXANDER, Martin. Biodegradation and bioremediation. San Diego: Academic Press, 1994. 302 s. ISBN 0-12-049860-X. info
Teaching methods
Lectures on selected parts of biotechnology. Discussions on detailed subjects.
Assessment methods
Lectures, discussions during lectures. Oral exam. Understanding of principles and processes is required. Fifty % of correct answers from the part of bioprocess kinetics is required to continue with the exam.
Language of instruction
Czech
Further comments (probably available only in Czech)
The course can also be completed outside the examination period.
The course is taught annually.
The course is taught: every week.
Listed among pre-requisites of other courses
Teacher's information
Absolvent kursu získá znalosti o vybraných klasických i moderních biotechnologiích založených na použití mikroorganismů, dalších buněčných kultur a enzymů. Dále je hlavní pozornost věnována principům procesů uplatňujících se v biotechnologii (zejména v bioreaktorech) nezávisle na použitých organismech nebo enzymech. Znalost těchto procesů je využitelná v laboratorním i větším měřítku a kromě oblasti biotechnologie bude užitečná i při studiu fyziologie mikroorganismů a dalších buněčných kultur.
The course is also listed under the following terms Spring 2008 - for the purpose of the accreditation, Spring 2011 - only for the accreditation, Spring 2000, Spring 2001, Spring 2002, Spring 2003, Spring 2004, Spring 2005, Spring 2006, Spring 2007, Spring 2008, Spring 2009, Spring 2010, Spring 2011, Spring 2012, spring 2012 - acreditation, Spring 2013, Spring 2014, Spring 2015, Spring 2016, Spring 2017.
  • Enrolment Statistics (recent)
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