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@proceedings{1104695,
author = {Knopfová, Lucia and Beneš, Petr and Hermanová, Markéta and Masařík, Michal and Šmarda, Jan},
booktitle = {The 9th Symposium on Molecular Pathology and Histo(cyto)chemistry},
keywords = {c-Myb; breast tumor; tumor microenvironment; invasivity},
language = {eng},
isbn = {978-80-7471-022-3},
title = {Microenvironment-dependent function of c-Myb in breast cancer: the focus on the tumor-endothelial cell interactions},
year = {2013}
}
TY - CONF
ID - 1104695
AU - Knopfová, Lucia - Beneš, Petr - Hermanová, Markéta - Masařík, Michal - Šmarda, Jan
PY - 2013
TI - Microenvironment-dependent function of c-Myb in breast cancer: the focus on the tumor-endothelial cell interactions
SN - 9788074710223
KW - c-Myb
KW - breast tumor
KW - tumor microenvironment
KW - invasivity
N2 - Deregulation of c-Myb occurs frequently in breast cancer and other malignancies. We described that the Myb overexpression in breast carcinoma cell lines can differentially affect cell migration and invasion in vitro depending on chemotaktic/chemokinetic conditions and matrix composition. The Myb-overexpressing mammary tumors in syngeneic BALB/C model rarely metastasized to lungs in contrast to control tumors, though the formation of the bone and liver metastases was not affected. The selective disdavantage of these cells in lung colonization might result frem their inability to penetrate a vessel wall and underlying basement membrane in lung parenchyma. We targeted the specific aspects of tumor-endothelial cell intractions and demonstrated the capacity of transendothelial migration of the Myb-overexpressing MDA-MB-231 cells was impaired.The differential regulation of cytoskeleton dynamics and suppression of interstitial collagenase may contribute to the damaged extravasation and site-selective metastases of the Myb-overexpressing breast tumors.
ER -
KNOPFOVÁ, Lucia, Petr BENEŠ, Markéta HERMANOVÁ, Michal MASAŘÍK a Jan ŠMARDA. Microenvironment-dependent function of c-Myb in breast cancer: the focus on the tumor-endothelial cell interactions. In \textit{The 9th Symposium on Molecular Pathology and Histo(cyto)chemistry}. 2013. ISBN~978-80-7471-022-3.
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