2013
Apolipoprotein E gene polymorphisms in chronic periodontitis
BOŘILOVÁ LINHARTOVÁ, Petra, Jan MÁCHAL, Jiřina BÁRTOVÁ, Hana POSKEROVÁ, Jan VOKURKA et. al.Základní údaje
Originální název
Apolipoprotein E gene polymorphisms in chronic periodontitis
Autoři
BOŘILOVÁ LINHARTOVÁ, Petra (203 Česká republika, domácí), Jan MÁCHAL (203 Česká republika, domácí), Jiřina BÁRTOVÁ (203 Česká republika, domácí), Hana POSKEROVÁ (203 Česká republika, domácí), Jan VOKURKA (203 Česká republika, domácí), Antonín FASSMANN (203 Česká republika, domácí) a Lydie IZAKOVIČOVÁ HOLLÁ (203 Česká republika, garant, domácí)
Vydání
FEBS CONGRESS 2013, Sankt Petersburg, Russia, FEBS Journal, vol. 280, suppl. 1, pp. 457. 2013
Další údaje
Jazyk
angličtina
Typ výsledku
Konferenční abstrakt
Obor
Genetika a molekulární biologie
Stát vydavatele
Spojené státy
Utajení
není předmětem státního či obchodního tajemství
Impakt faktor
Impact factor: 3.986
Kód RIV
RIV/00216224:14110/13:00065618
Organizační jednotka
Lékařská fakulta
ISSN
UT WoS
000325919202433
Klíčová slova anglicky
ApoE; chronic periodontitis; gene polymorphism; microbial colonization
Změněno: 26. 7. 2013 13:40, doc. RNDr. Petra Bořilová Linhartová, Ph.D., MBA
Anotace
V originále
Objective: Periodontal diseases can be related to common systemic conditions, and, as recently described, alterations in blood lipid levels. The aim of this study was to analyze two apolipoprotein E (ApoE) gene polymorphisms in patients with chronic periodontitis (CP) in relation to periodontopathic bacteria and lipid levels. Methods: 469 unrelated subjects were included in this case-control study. Genomic DNA of 294 patients with CP and 175 healthy/non-periodontitis controls were genotyped, using the real-time polymerase chain reaction (RT-PCR) method monitored by SYBR Green, for ApoE (rs429358 and rs7412) gene polymorphisms. Subgingival bacterial colonization was investigated by the DNA-microarray based on a periodontal pathogen detection kit and lipid levels were measured in a subgroup of subjects. Results: There was no evidence for a significant association between ApoE gene polymorphisms and CP (E2/E2 vs. E3/E3: OR=0.63, 95%CI=0.12-3.15; E2/E3 vs. E3/E3: OR=1.61, 95%CI=0.84-3.11; E2/E4 vs. E3/E3: OR=1.25, 95%CI=0.23-6.95; E3/E4 vs. E3/E3: OR=1.11, 95%CI=0.65-1.88; E4/E4 vs. E3/E3: OR=0.63, 95%CI=0.15-2.55; allele E2 vs. allele E3: OR=1.26, 95%CI=0.74-2.14; allele E4 vs. allele E3: OR=0.97, 95%CI=0.63-1.51). Patients with CP had increased total cholesterol and LDL levels compared to controls (P<0.05), however no significant differences were found for triglyceride and HDL levels. Gene variability in the ApoE gene influenced LDL levels marginally (P=0.07) but did not modify total cholesterol, triglyceride and HDL levels or the occurrence of periodontal pathogens in subgingival pockets. Conclusions: In Czech population studied, ApoE genetic variations rs429358 and rs7412 were not associated with susceptibility to and severity of chronic periodontitis or with the presence of periodontopathic bacteria.
Návaznosti
MUNI/A/0888/2012, interní kód MU |
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NT11405, projekt VaV |
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