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@article{1321781,
author = {Pospíšil, Petr and Kazda, Tomáš and Bulik, Martin and Dobiášková, Marie and Burkoň, Petr and Hynková, Ludmila and Šlampa, Pavel and Jančálek, Radim},
article_location = {London},
article_number = {211},
doi = {http://dx.doi.org/10.1186/s13014-015-0518-1},
keywords = {Hippocampus; Radiation injury; Neurocognitive function; Magnetic resonance spectroscopy},
language = {eng},
issn = {1748-717X},
journal = {Radiation Oncology},
title = {Hippocampal proton MR spectroscopy as a novel approach in the assessment of radiation injury and the correlation to neurocognitive function impairment: initial experiences},
volume = {10},
year = {2015}
}
TY - JOUR
ID - 1321781
AU - Pospíšil, Petr - Kazda, Tomáš - Bulik, Martin - Dobiášková, Marie - Burkoň, Petr - Hynková, Ludmila - Šlampa, Pavel - Jančálek, Radim
PY - 2015
TI - Hippocampal proton MR spectroscopy as a novel approach in the assessment of radiation injury and the correlation to neurocognitive function impairment: initial experiences
JF - Radiation Oncology
VL - 10
IS - 211
SP - 1-8
EP - 1-8
PB - BioMed Central
SN - 1748717X
KW - Hippocampus
KW - Radiation injury
KW - Neurocognitive function
KW - Magnetic resonance spectroscopy
N2 - Background: The hippocampus is considered as the main radiosensitive brain structure responsible for postradiotherapy cognitive decline. We prospectively assessed correlation of memory change to hippocampal N-acetylaspartate (h-tNAA) concentration, a neuronal density and viability marker, by H-1-MR spectroscopy focused on the hippocampus. Methods: Patients with brain metastases underwent whole brain radiotherapy (WBRT) to a dose of 30 Gy in ten fractions daily. Pre-radiotherapy H-1-MR spectroscopy focused on the h-tNAA concentration and memory testing was performed. Memory was evaluated by Auditory Verbal Learning Test (AVLT) and Brief Visuospatial Memory Test-Revised (BVMT-R). Total recall, recognition and delayed recall were reported. The both investigation procedures were repeated 4 months after WBRT and the h-tNAA and memory changes were correlated. Results: Of the 20 patients, ten passed whole protocol. The h-tNAA concentration significantly decreased from pre-WBRT 8.9, 8.86 and 8.88 [mM] in the right, left and both hippocampi to 7.16, 7.65 and 7.4 after WBRT, respectively. In the memory tests a significant decrease was observed in AVLT total-recall, BVMT-R total-recall and BVMT-R delayed-recall. Weak to moderate correlations were observed between left h-tNAA and AVLT recognition and all BVMT-R subtests and between the right h-tNAA and AVLT total-recall. Conclusions: A significant decrease in h-tNAA after WBRT was proven by H-1-MR spectroscopy as a feasible method for the in vivo investigation of radiation injury. Continuing patient recruitment focusing on other cognitive tests and metabolites is needed.
ER -
POSPÍŠIL, Petr, Tomáš KAZDA, Martin BULIK, Marie DOBIÁŠKOVÁ, Petr BURKOŇ, Ludmila HYNKOVÁ, Pavel ŠLAMPA a Radim JANČÁLEK. Hippocampal proton MR spectroscopy as a novel approach in the assessment of radiation injury and the correlation to neurocognitive function impairment: initial experiences. \textit{Radiation Oncology}. London: BioMed Central, 2015, roč.~10, č.~211, s.~1-8. ISSN~1748-717X. Dostupné z: https://dx.doi.org/10.1186/s13014-015-0518-1.
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