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@article{1347537,
author = {Bartáková, Vendula and Pleskačová, Anna and Kuricová, Katarína and Pácal, Lukáš and Dvořáková, Veronika and Bělobrádková, Jana and Tomandlová, Marie and Tomandl, Josef and Kaňková, Kateřina},
article_location = {Dordrecht},
article_number = {4},
doi = {http://dx.doi.org/10.1007/s10719-016-9688-9},
keywords = {thiamine; gestational diabetes mellitus; pregnancy; advanced glycation end porducts},
language = {eng},
issn = {0282-0080},
journal = {Glycoconjugate Journal},
title = {Dysfunctional protection against advanced glycation due to thiamine metabolism abnormalities in gestational diabetes},
url = {http://link.springer.com/article/10.1007/s10719-016-9688-9},
volume = {33},
year = {2016}
}
TY - JOUR
ID - 1347537
AU - Bartáková, Vendula - Pleskačová, Anna - Kuricová, Katarína - Pácal, Lukáš - Dvořáková, Veronika - Bělobrádková, Jana - Tomandlová, Marie - Tomandl, Josef - Kaňková, Kateřina
PY - 2016
TI - Dysfunctional protection against advanced glycation due to thiamine metabolism abnormalities in gestational diabetes
JF - Glycoconjugate Journal
VL - 33
IS - 4
SP - 591-598
EP - 591-598
PB - Springer
SN - 02820080
KW - thiamine
KW - gestational diabetes mellitus
KW - pregnancy
KW - advanced glycation end porducts
UR - http://link.springer.com/article/10.1007/s10719-016-9688-9
L2 - http://link.springer.com/article/10.1007/s10719-016-9688-9
N2 - While the pathogenic role of dicarbonyl stress and accelerated formation of advanced glycation end products (AGEs) to glucose intolerance and to the development of diabetic complications is well established, little is known about these processes in gestational diabetes mellitus (GDM), a condition pathogenically quite similar to type 2 diabetes. The aims of the present study were (i) to determine plasma thiamine and erythrocyte thiamine diphosphate (TDP) and transketolase (TKT) activity in pregnant women with and without GDM, (ii) to assess relationships between thiamine metabolism parameters and selected clinical, biochemical and anthropometric characteristics and, finally, (iii) to analyse relationship between variability in the genes involved in the regulation of transmembrane thiamine transport (i.e. SLC19A2 and SLC19A3) and relevant parameters of thiamine metabolism. We found significantly lower plasma BMI adjusted thiamine in women with GDM (P = 0.002, Mann-Whitney) while levels of erythrocyte TDP (an active TKT cofactor) in mid-trimester were significantly higher in GDM compared to controls (P = 0.04, Mann-Whitney). However, mid-gestational TKT activity - reflecting pentose phosphate pathway activity - did not differ between the two groups (P > 0.05, Mann-Whitney). Furthermore, we ascertained significant associations of postpartum TKT activity with SNPs SLC19A2 rs6656822 and SLC19A3 rs7567984 (P = 0.03 and P = 0.007, resp., Kruskal-Wallis). Our findings of increased thiamine delivery to the cells without concomitant increase of TKT activity in women with GDM therefore indicate possible pathogenic role of thiamine mishandling in GDM. Further studies are needed to determine its contribution to maternal and/or neonatal morbidity.
ER -
BARTÁKOVÁ, Vendula, Anna PLESKAČOVÁ, Katarína KURICOVÁ, Lukáš PÁCAL, Veronika DVOŘÁKOVÁ, Jana BĚLOBRÁDKOVÁ, Marie TOMANDLOVÁ, Josef TOMANDL a Kateřina KAŇKOVÁ. Dysfunctional protection against advanced glycation due to thiamine metabolism abnormalities in gestational diabetes. \textit{Glycoconjugate Journal}. Dordrecht: Springer, 2016, roč.~33, č.~4, s.~591-598. ISSN~0282-0080. Dostupné z: https://dx.doi.org/10.1007/s10719-016-9688-9.
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