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@article{1354608,
author = {Zambo, Iva and Hermanová, Markéta and Zapletalová, Danica and Škoda, Jan and Múdry, Peter and Kýr, Michal and Zitterbart, Karel and Štěrba, Jaroslav and Veselská, Renata},
article_location = {Amsterdam},
article_number = {1},
doi = {http://dx.doi.org/10.3233/CBM-160623},
keywords = {rhabdomyosarcoma;Ewing sarcoma;osteosarcoma;cancer stem cell markers;prognosis},
language = {eng},
issn = {1574-0153},
journal = {Cancer Biomarkers},
title = {Expression of nestin, CD133 and ABCG2 in relation to the clinical outcome in pediatric sarcomas},
volume = {17},
year = {2016}
}
TY - JOUR
ID - 1354608
AU - Zambo, Iva - Hermanová, Markéta - Zapletalová, Danica - Škoda, Jan - Múdry, Peter - Kýr, Michal - Zitterbart, Karel - Štěrba, Jaroslav - Veselská, Renata
PY - 2016
TI - Expression of nestin, CD133 and ABCG2 in relation to the clinical outcome in pediatric sarcomas
JF - Cancer Biomarkers
VL - 17
IS - 1
SP - 107-116
EP - 107-116
PB - IOS Press
SN - 15740153
KW - rhabdomyosarcoma;Ewing sarcoma;osteosarcoma;cancer stem cell markers;prognosis
N2 - Nestin, CD133 and ABCG2 are recently discussed as putative markers, co-expression of which might determine a cancer stem cell (CSC) phenotype in sarcomas. Our study is focused on immunohistochemical analysis of nestin, CD133 and ABCG2 expression in rhabdomyosarcoma, Ewing sarcoma and osteosarcoma. Furthermore, we also analyzed the possible correlation of nestin, CD133 and ABCG2 expression levels with the patient outcome to identify potential prognostic values of these three putative CSC markers in the same cohorts. Using immunohistochemistry, expression of nestin, CD133 and ABCG2 was analyzed in 24 rhabdomyosarcoma, 22 Ewing sarcoma and 10 osteosarcoma tissue samples and expression levels of these markers were correlated with clinical outcome. High nestin levels indicate poor prognosis in patients with Ewing sarcoma (P = 0.001), and high CD133 expression is associated with shorter survival in rhabdomyosarcoma patients (P = 0.002). In contrast, no significant relationship was found between ABCG2 expression and the clinical outcome. Our analysis represents the first complex study of these three putative CSCs markers together in three different types of pediatric sarcomas and showed their possible prognostic values in these tumors.
ER -
ZAMBO, Iva, Markéta HERMANOVÁ, Danica ZAPLETALOVÁ, Jan ŠKODA, Peter MÚDRY, Michal KÝR, Karel ZITTERBART, Jaroslav ŠTĚRBA a Renata VESELSKÁ. Expression of nestin, CD133 and ABCG2 in relation to the clinical outcome in pediatric sarcomas. \textit{Cancer Biomarkers}. Amsterdam: IOS Press, 2016, roč.~17, č.~1, s.~107-116. ISSN~1574-0153. Dostupné z: https://dx.doi.org/10.3233/CBM-160623.
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