Adiponectin gene variability in relation to body mass index and
lipid profile in patients with diabetes mellitus type 2 and
chronic periodontitis

a 2017

Adiponectin gene variability in relation to body mass index and lipid profile in patients with diabetes mellitus type 2 and chronic periodontitis

JÁNOŠ, Július, Petra BOŘILOVÁ LINHARTOVÁ, Hana POSKEROVÁ, Antonín FASSMANN, Kateřina KAŇKOVÁ et. al.

Základní údaje

Originální název

Adiponectin gene variability in relation to body mass index and lipid profile in patients with diabetes mellitus type 2 and chronic periodontitis

Autoři

JÁNOŠ, Július, Petra BOŘILOVÁ LINHARTOVÁ, Hana POSKEROVÁ, Antonín FASSMANN, Kateřina KAŇKOVÁ a Lydie IZAKOVIČOVÁ HOLLÁ

Vydání

Lipid mediators in ageing and disease, Aston University, UK, 2017, 2017

Další údaje

Typ výsledku

Konferenční abstrakt

Utajení

není předmětem státního či obchodního tajemství

Klíčová slova anglicky

adiponectin, gene polymorphism, diabetes mellitus, chronic periodontitis, lipid metabolism

Příznaky

Mezinárodní význam

Změněno: 6. 2. 2017 10:19, doc. RNDr. Petra Bořilová Linhartová, Ph.D., MBA

Anotace

V originále

The relationship between obesity, diabetes mellitus type 2 (T2DM) and chronic periodontitis (CP), characterized by low-grade inflammation, was described. Adiponectin (ADIPOQ) regulates inflammatory responses and has multiple favorable effects on glucose and lipid metabolism. The aim of present study was to analyze ADIPOQ gene variability in healthy controls and patients with T2DM and/or CP. Altogether, 685 unrelated subjects were included in this case-control study. Genomic DNA of 104 healthy/non-periodontitis controls, 202 patients with CP and 380 T2DM patients (including 88 patients with T2DM and CP) were genotyped using the real-time PCR TaqMan method for +276G/T (rs1501299) polymorphism in the ADIPOQ gene. Clinical (diabetic complications, periodontal status, body mass index=BMI), biochemical (lipid profile, blood glucose and glycated hemoglobin levels) and microbial parameters (7 selected periodontal pathogens) were recorded. No association between ADIPOQ gene polymorphism and T2DM and/or CP was found (P>0.05). Subjects with TT genotype had significantly higher BMI and decreased median of high density lipoprotein (HDL) levels than in carriers of GT/GG genotypes (P≤0.01). However, no significant differences were found for triglycerides, total cholesterol, low-DL levels and other monitored parameters. Although the ADIPOQ gene variability +276G/T (rs1501299) was not associated with susceptibility to and severity of T2DM and/or CP in the Czech population, TT carriers may have a higher risk of obesity and dysregulation of lipid metabolism. The study was supported by project MUNI/A/1258/2015, MUNI/A/1265/2015 and grant GB14-37368G.

Návaznosti

GB14-37368G, projekt VaV

Název: Centrum orofaciálního vývoje a regenerace

Investor: Grantová agentura ČR, Centrum orofaciálního vývoje a regenerace

MUNI/A/1258/2015, interní kód MU

Název: Analýza klinických, mikrobiálních a genetických faktorů v etiopatogenezi vybraných patologických stavů v dutině ústní

Investor: Masarykova univerzita, Analýza klinických, mikrobiálních a genetických faktorů v etiopatogenezi vybraných patologických stavů v dutině ústní, DO R. 2020_Kategorie A - Specifický výzkum - Studentské výzkumné projekty

MUNI/A/1265/2015, interní kód MU

Název: Podpora biochemického výzkumu v roce 2016

Investor: Masarykova univerzita, Podpora biochemického výzkumu v roce 2016, DO R. 2020_Kategorie A - Specifický výzkum - Studentské výzkumné projekty

Citovat

JÁNOŠ, Július, Petra BOŘILOVÁ LINHARTOVÁ, Hana POSKEROVÁ, Antonín FASSMANN, Kateřina KAŇKOVÁ a Lydie IZAKOVIČOVÁ HOLLÁ. Adiponectin gene variability in relation to body mass index and lipid profile in patients with diabetes mellitus type 2 and chronic periodontitis. In Lipid mediators in ageing and disease, Aston University, UK, 2017. 2017.

@proceedings{1371602,
   author = {Jánoš, Július and Bořilová Linhartová, Petra and Poskerová, Hana and Fassmann, Antonín and Kaňková, Kateřina and Izakovičová Hollá, Lydie},
   booktitle = {Lipid mediators in ageing and disease, Aston University, UK, 2017},
   keywords = {adiponectin, gene polymorphism, diabetes mellitus, chronic periodontitis, lipid metabolism},
   title = {Adiponectin gene variability in relation to body mass index and lipid profile in patients with diabetes mellitus type 2 and chronic periodontitis},
   year = {2017}
}

TY  - CONF
ID  - 1371602
AU  - Jánoš, Július - Bořilová Linhartová, Petra - Poskerová, Hana - Fassmann, Antonín - Kaňková, Kateřina - Izakovičová Hollá, Lydie
PY  - 2017
TI  - Adiponectin gene variability in relation to body mass index and lipid profile in patients with diabetes mellitus type 2 and chronic periodontitis
KW  - adiponectin, gene polymorphism, diabetes mellitus, chronic periodontitis, lipid metabolism
N2  - The relationship between obesity, diabetes mellitus type 2 (T2DM) and chronic periodontitis (CP), characterized by low-grade inflammation, was described. Adiponectin (ADIPOQ) regulates inflammatory responses and has multiple favorable effects on glucose and lipid metabolism. The aim of present study was to analyze ADIPOQ gene variability in healthy controls and patients with T2DM and/or CP. Altogether, 685 unrelated subjects were included in this case-control study. Genomic DNA of 104 healthy/non-periodontitis controls, 202 patients with CP and 380 T2DM patients (including 88 patients with T2DM and CP) were genotyped using the real-time PCR TaqMan method for +276G/T (rs1501299) polymorphism in the ADIPOQ gene. Clinical (diabetic complications, periodontal status, body mass index=BMI), biochemical (lipid profile, blood glucose and glycated hemoglobin levels) and microbial parameters (7 selected periodontal pathogens) were recorded. No association between ADIPOQ gene polymorphism and T2DM and/or CP was found (P>0.05). Subjects with TT genotype had significantly higher BMI and decreased median of high density lipoprotein (HDL) levels than in carriers of GT/GG genotypes (P≤0.01). However, no significant differences were found for triglycerides, total cholesterol, low-DL levels and other monitored parameters. Although the ADIPOQ gene variability +276G/T (rs1501299) was not associated with susceptibility to and severity of T2DM and/or CP in the Czech population, TT carriers may have a higher risk of obesity and dysregulation of lipid metabolism. The study was supported by project MUNI/A/1258/2015, MUNI/A/1265/2015 and grant GB14-37368G.
ER  -

JÁNOŠ, Július, Petra BOŘILOVÁ LINHARTOVÁ, Hana POSKEROVÁ, Antonín FASSMANN, Kateřina KAŇKOVÁ a Lydie IZAKOVIČOVÁ HOLLÁ. Adiponectin gene variability in relation to body mass index and lipid profile in patients with diabetes mellitus type 2 and chronic periodontitis. In \textit{Lipid mediators in ageing and disease, Aston University, UK, 2017}. 2017.

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