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@article{1449676,
author = {Handl, Marek and Hermanová, Markéta and Hotárková, Sylva and Jarkovský, Jiří and Múdry, Peter and Shatokhina, Tetiana and Vesela, Marcela and Štěrba, Jaroslav and Zambo, Iva},
article_location = {Olomouc},
article_number = {1},
doi = {http://dx.doi.org/10.5507/bp.2017.049},
keywords = {tumor associated macrophages; Ewing sarcoma; immunohistochemistry; CD68; CD163; prognosis},
language = {eng},
issn = {1213-8118},
journal = {Biomedical Papers, Olomouc: Palacky University},
title = {Clinicopathological correlation of tumor-associated macrophages in Ewing sarcoma},
volume = {162},
year = {2018}
}
TY - JOUR
ID - 1449676
AU - Handl, Marek - Hermanová, Markéta - Hotárková, Sylva - Jarkovský, Jiří - Múdry, Peter - Shatokhina, Tetiana - Vesela, Marcela - Štěrba, Jaroslav - Zambo, Iva
PY - 2018
TI - Clinicopathological correlation of tumor-associated macrophages in Ewing sarcoma
JF - Biomedical Papers, Olomouc: Palacky University
VL - 162
IS - 1
SP - 54-60
EP - 54-60
PB - Palacky University
SN - 12138118
KW - tumor associated macrophages
KW - Ewing sarcoma
KW - immunohistochemistry
KW - CD68
KW - CD163
KW - prognosis
N2 - Aims. Tumor-associated macrophages (TAMs) are known markers playing complex roles in tumorigenesis. However, the function of TAMs in a variety of malignancies is not yet fully understood. The aim of this pilot study was to quantify the density of TAMs in Ewing sarcoma and to determine the correlation between TAMs and clinicopathological parameters. Methods. Using immunohistochemistry, the expressions of CD68 and CD163 were examined in 24 tissue samples of Ewing sarcoma of bone. The density of CD68 and CD163-positive TAMs was analyzed quantitatively and semi-quantitatively and statistically correlated with clinical parameters. Results. CD163-positive TAMs outnumbered CD68-positive cells (median of 130 vs 96, respectively). No statistically significant relatio nship was found between density of CD68-positive cells, clinical parameters or prognosis. However, high levels of CD163-positive TAMs were associated with localized disease (P=0.008). In cases with a higher density of CD163-positive cells, a trend toward longer survival was revealed (P=0.063). Conclusion. This is the first study that has quantified CD163 expression in TAMs in Ewing sarcoma and showed its possible prognostic value. CD163 was confirmed to be a more specific marker of macrophages than CD68. CD163 is not an exclusive hallmark of M2 macrophages.
ER -
HANDL, Marek, Markéta HERMANOVÁ, Sylva HOTÁRKOVÁ, Jiří JARKOVSKÝ, Peter MÚDRY, Tetiana SHATOKHINA, Marcela VESELA, Jaroslav ŠTĚRBA a Iva ZAMBO. Clinicopathological correlation of tumor-associated macrophages in Ewing sarcoma. \textit{Biomedical Papers, Olomouc: Palacky University}. Olomouc: Palacky University, roč.~162, č.~1, s.~54-60. ISSN~1213-8118. doi:10.5507/bp.2017.049. 2018.
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