Granulation tissue enriched by aspirin and omega-3 fatty acids
in healing experimental periodontal lesion

J 2021

Granulation tissue enriched by aspirin and omega-3 fatty acids in healing experimental periodontal lesion

HROMČÍK, Filip; Jan VOKURKA; Eduard GÖPFERT; Martin FALDYNA; Markéta HERMANOVÁ et al.

Základní údaje

Originální název

Granulation tissue enriched by aspirin and omega-3 fatty acids in healing experimental periodontal lesion

Název česky

Granulační tkáň obohacená aspirinem a omega3 mastnými kyselinami v hojení experimentálního parodontálního defektu

Autoři

HROMČÍK, Filip ; Jan VOKURKA; Eduard GÖPFERT; Martin FALDYNA; Markéta HERMANOVÁ; Michal KÝR; Monika VICENOVÁ a Lydie IZAKOVIČOVÁ HOLLÁ

Vydání

Biomedical Papers, Olomouc, Univerzita Palackého v Olomouci, 2021, 1213-8118

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30208 Dentistry, oral surgery and medicine

Stát vydavatele

Česká republika

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 1.648

Označené pro přenos do RIV

Ano

Kód RIV

RIV/00216224:14110/21:00120585

Organizační jednotka

Lékařská fakulta

Klíčová slova česky

parodontitis; granulační tkáň; lipoxin; resolvin; chirurgie; EGT

Klíčová slova anglicky

EGT approach; EGT; periodontitis; lipoxin; resolvin; pro-resolving mediators

Štítky

14110112, 14110130, 14110321, EGT approach, enhanced granulation tissue, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 24. 10. 2022 08:42, Mgr. Tereza Miškechová

Anotace

V originále

Aims. Granulation tissue (GT) and specialized proresolving mediators such as lipoxins and resolvins are key elements in the successful resolution of periodontitis. Aspirin triggered lipoxins and resolvins are even more powerful than their natural analogues. Their biosynthesis can be accelerated by omega3 fatty acids. The aim of this study was to evaluate the use of GT enriched by aspirin and omega‑3 fatty acids during the surgical treatment of periodontitis in an experimental animal model (rabbit). Methods. In each of 24 rabbits, two experimental periodontal defects were created. In total, 47 defects were treated with open flap debridement and one of three procedures: (1) GT extracted and soaked with aspirin and omega‑3 fatty acids (ASA+OMEGA3 group); (2) GT soaked with saline (PLACEBO group); or (3) GT left untreated (CONTROL group). Then, the GT was replaced in situ. Primary evaluated criteria were the probing pocket depth (PPD) and the clinical at‑ tachment level (CAL). Necropsies were harvested 2, 6, and 12 weeks after surgery. The samples were used for histological and molecular biological assessment. Results. A trend of greater PPD and CAL in the ASA+OMEGA3 group was observed at 6 weeks. However, there was no significant difference between them. During the observation period, tissue levels of FGF‑7, IL1β and TIMP1 showed a statistically significant decrease (P<0.05). For the other variables, the ASA+OMEGA3 group was comparable with the PLACEBO and CONTROL groups. Conclusion. This experiment did not demonstrate the superiority of the proposed approach. However, the enriched granulation tissue did not impair healing outcomes.

Přiložené soubory

Hromcik_-_GRANULATION_TISSUE_ENRICHED_BY_ASPIRIN_AND_OMEGA-3_FATTY_ACIDS_IN_HEALING_EXPERIMENTAL_PERIODONTAL_LESION_Final.pdf

Citovat

HROMČÍK, Filip; Jan VOKURKA; Eduard GÖPFERT; Martin FALDYNA; Markéta HERMANOVÁ; Michal KÝR; Monika VICENOVÁ a Lydie IZAKOVIČOVÁ HOLLÁ. Granulation tissue enriched by aspirin and omega-3 fatty acids in healing experimental periodontal lesion. Biomedical Papers. Olomouc: Univerzita Palackého v Olomouci, 2021, roč. 165, č. 2, s. 216-223. ISSN 1213-8118. Dostupné z: https://doi.org/10.5507/bp.2020.003.

@article{1630376,
   author = {Hromčík, Filip and Vokurka, Jan and Göpfert, Eduard and Faldyna, Martin and Hermanová, Markéta and Kýr, Michal and Vicenová, Monika and Izakovičová Hollá, Lydie},
   article_location = {Olomouc},
   article_number = {2},
   doi = {https://doi.org/10.5507/bp.2020.003},
   keywords = {EGT approach; EGT; periodontitis; lipoxin; resolvin; pro-resolving mediators},
   language = {eng},
   issn = {1213-8118},
   journal = {Biomedical Papers},
   title = {Granulation tissue enriched by aspirin and omega-3 fatty acids in healing experimental periodontal lesion},
   url = {https://biomed.papers.upol.cz/corproof.php?tartkey=bio-000000-2352&fbclid=IwAR1g0vgpY79Itq4sCvVmOyPm0Hnt4_ll5VrbekN1169lRRt9oPE73iPjCz0},
   volume = {165},
   year = {2021}
}

TY  - JOUR
ID  - 1630376
AU  - Hromčík, Filip - Vokurka, Jan - Göpfert, Eduard - Faldyna, Martin - Hermanová, Markéta - Kýr, Michal - Vicenová, Monika - Izakovičová Hollá, Lydie
PY  - 2021
TI  - Granulation tissue enriched by aspirin and omega-3 fatty acids in healing experimental periodontal lesion
JF  - Biomedical Papers
VL  - 165
IS  - 2
SP  - 216-223
EP  - 216-223
PB  - Univerzita Palackého v Olomouci
SN  - 12138118
KW  - EGT approach
KW  - EGT
KW  - periodontitis
KW  - lipoxin
KW  - resolvin
KW  - pro-resolving mediators
UR  - https://biomed.papers.upol.cz/corproof.php?tartkey=bio-000000-2352&fbclid=IwAR1g0vgpY79Itq4sCvVmOyPm0Hnt4_ll5VrbekN1169lRRt9oPE73iPjCz0
L2  - https://biomed.papers.upol.cz/corproof.php?tartkey=bio-000000-2352&fbclid=IwAR1g0vgpY79Itq4sCvVmOyPm0Hnt4_ll5VrbekN1169lRRt9oPE73iPjCz0
N2  - Aims. Granulation tissue (GT) and specialized proresolving mediators such as lipoxins and resolvins are key elements in the successful resolution of periodontitis. Aspirin triggered lipoxins and resolvins are even more powerful than their natural analogues. Their biosynthesis can be accelerated by omega3 fatty acids. The aim of this study was to evaluate the use of GT enriched by aspirin and omega‑3 fatty acids during the surgical treatment of periodontitis in an experimental animal model (rabbit). Methods. In each of 24 rabbits, two experimental periodontal defects were created. In total, 47 defects were treated with open flap debridement and one of three procedures: (1) GT extracted and soaked with aspirin and omega‑3 fatty acids (ASA+OMEGA3 group); (2) GT soaked with saline (PLACEBO group); or (3) GT left untreated (CONTROL group). Then, the GT was replaced in situ. Primary evaluated criteria were the probing pocket depth (PPD) and the clinical at‑ tachment level (CAL). Necropsies were harvested 2, 6, and 12 weeks after surgery. The samples were used for histological and molecular biological assessment. Results. A trend of greater PPD and CAL in the ASA+OMEGA3 group was observed at 6 weeks. However, there was no significant difference between them. During the observation period, tissue levels of FGF‑7, IL1β and TIMP1 showed a statistically significant decrease (P<0.05). For the other variables, the ASA+OMEGA3 group was comparable with the PLACEBO and CONTROL groups. Conclusion. This experiment did not demonstrate the superiority of the proposed approach. However, the enriched granulation tissue did not impair healing outcomes.
ER  -

HROMČÍK, Filip; Jan VOKURKA; Eduard GÖPFERT; Martin FALDYNA; Markéta HERMANOVÁ; Michal KÝR; Monika VICENOVÁ a Lydie IZAKOVIČOVÁ HOLLÁ. Granulation tissue enriched by aspirin and omega-3 fatty acids in healing experimental periodontal lesion. \textit{Biomedical Papers}. Olomouc: Univerzita Palackého v Olomouci, 2021, roč.~165, č.~2, s.~216-223. ISSN~1213-8118. Dostupné z: https://doi.org/10.5507/bp.2020.003.

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