The tumor immune microenvironment and its implications for
clinical outcome in patients with oropharyngeal squamous cell
carcinoma

J 2020

The tumor immune microenvironment and its implications for clinical outcome in patients with oropharyngeal squamous cell carcinoma

GURÍN, Dominik; Marek SLÁVIK; Markéta HERMANOVÁ; Iveta SELINGEROVÁ; Tomáš KAZDA et. al.

Základní údaje

Originální název

The tumor immune microenvironment and its implications for clinical outcome in patients with oropharyngeal squamous cell carcinoma

Autoři

GURÍN, Dominik; Marek SLÁVIK; Markéta HERMANOVÁ; Iveta SELINGEROVÁ; Tomáš KAZDA; Michal HENDRYCH; Tetiana SHATOKHINA a Marcela VESELÁ

Vydání

JOURNAL OF ORAL PATHOLOGY & MEDICINE, HOBOKEN, WILEY, 2020, 0904-2512

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30109 Pathology

Stát vydavatele

Spojené státy

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 4.253

Kód RIV

RIV/00216224:14110/20:00116131

Organizační jednotka

Lékařská fakulta

DOI

https://doi.org/10.1111/jop.13055

UT WoS

000544754600001

EID Scopus

2-s2.0-85087306024

Klíčová slova anglicky

CD8; HPV; oropharyngeal squamous cell carcinoma; PD-L1; tumor-infiltrating lymphocytes

Štítky

14110112, 14110812, podil, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 29. 10. 2020 13:38, Mgr. Tereza Miškechová

Anotace

V originále

Background We examined PD-L1 expression on tumor cells (TCs) and immune cells (ICs) and density of CD3(+)and CD8(+)tumor-infiltrating lymphocytes (TILs) in patients with oropharyngeal squamous cell carcinoma (OPSCC) and investigated their significance on clinicopathological characteristics and clinical outcomes. Methods In a cohort of 65 patients treated by definitive intensity-modulated radiotherapy (IMRT) with curative intent, immunohistochemical analysis of PD-L1 expression on TCs and ICs, and TIL subtyping was performed on primary biopsy tumor tissues, followed by prognostic evaluation of these immune response-related parameters including classification into four tumor immune microenvironment (TIM) types. To evaluate HPV status, p16 immunohistochemistry was performed. Results Densities of CD3(+)and CD8(+)TILs and PD-L1 expressions on TCs and ICs were significantly higher in p16+/HPV-mediated OPSCC. Patients with high densities of stromal CD8(+)TILs displayed significantly better overall survival (OS) and progression-free survival (PFS). PD-L1 expression neither on tumor cells nor on immune cells affected survival outcomes. Distribution of TIM types based on the combination of PD-L1 expression on TCs and densities of CD8(+)TILs is significantly different in p16+ compared with p16- OPSCC. In type III TIM (TC-PD-L1+/low CD8(+)TIL density), significantly better OS was shown in p16+ group compared with p16- OPSCC. Conclusion The prognostic and predictive role of tumor immune microenvironment was confirmed for patients with OPSCC. Combining HPV status with the evaluation of densities of CD8(+)TILs and PD-L1 expression including TIM classification might be of high clinical interest and warrants further prospective evaluation.

Citovat

GURÍN, Dominik; Marek SLÁVIK; Markéta HERMANOVÁ; Iveta SELINGEROVÁ; Tomáš KAZDA; Michal HENDRYCH; Tetiana SHATOKHINA a Marcela VESELÁ. The tumor immune microenvironment and its implications for clinical outcome in patients with oropharyngeal squamous cell carcinoma. JOURNAL OF ORAL PATHOLOGY & MEDICINE. HOBOKEN: WILEY, 2020, roč. 49, č. 9, s. 886-896. ISSN 0904-2512. Dostupné z: https://doi.org/10.1111/jop.13055.

@article{1673160,
   author = {Gurín, Dominik and Slávik, Marek and Hermanová, Markéta and Selingerová, Iveta and Kazda, Tomáš and Hendrych, Michal and Shatokhina, Tetiana and Veselá, Marcela},
   article_location = {HOBOKEN},
   article_number = {9},
   doi = {https://doi.org/10.1111/jop.13055},
   keywords = {CD8; HPV; oropharyngeal squamous cell carcinoma; PD-L1; tumor-infiltrating lymphocytes},
   language = {eng},
   issn = {0904-2512},
   journal = {JOURNAL OF ORAL PATHOLOGY & MEDICINE},
   title = {The tumor immune microenvironment and its implications for clinical outcome in patients with oropharyngeal squamous cell carcinoma},
   url = {https://onlinelibrary.wiley.com/doi/full/10.1111/jop.13055},
   volume = {49},
   year = {2020}
}

TY  - JOUR
ID  - 1673160
AU  - Gurín, Dominik - Slávik, Marek - Hermanová, Markéta - Selingerová, Iveta - Kazda, Tomáš - Hendrych, Michal - Shatokhina, Tetiana - Veselá, Marcela
PY  - 2020
TI  - The tumor immune microenvironment and its implications for clinical outcome in patients with oropharyngeal squamous cell carcinoma
JF  - JOURNAL OF ORAL PATHOLOGY & MEDICINE
VL  - 49
IS  - 9
SP  - 886-896
EP  - 886-896
PB  - WILEY
SN  - 09042512
KW  - CD8
KW  - HPV
KW  - oropharyngeal squamous cell carcinoma
KW  - PD-L1
KW  - tumor-infiltrating lymphocytes
UR  - https://onlinelibrary.wiley.com/doi/full/10.1111/jop.13055
L2  - https://onlinelibrary.wiley.com/doi/full/10.1111/jop.13055
N2  - Background We examined PD-L1 expression on tumor cells (TCs) and immune cells (ICs) and density of CD3(+)and CD8(+)tumor-infiltrating lymphocytes (TILs) in patients with oropharyngeal squamous cell carcinoma (OPSCC) and investigated their significance on clinicopathological characteristics and clinical outcomes. Methods In a cohort of 65 patients treated by definitive intensity-modulated radiotherapy (IMRT) with curative intent, immunohistochemical analysis of PD-L1 expression on TCs and ICs, and TIL subtyping was performed on primary biopsy tumor tissues, followed by prognostic evaluation of these immune response-related parameters including classification into four tumor immune microenvironment (TIM) types. To evaluate HPV status, p16 immunohistochemistry was performed. Results Densities of CD3(+)and CD8(+)TILs and PD-L1 expressions on TCs and ICs were significantly higher in p16+/HPV-mediated OPSCC. Patients with high densities of stromal CD8(+)TILs displayed significantly better overall survival (OS) and progression-free survival (PFS). PD-L1 expression neither on tumor cells nor on immune cells affected survival outcomes. Distribution of TIM types based on the combination of PD-L1 expression on TCs and densities of CD8(+)TILs is significantly different in p16+ compared with p16- OPSCC. In type III TIM (TC-PD-L1+/low CD8(+)TIL density), significantly better OS was shown in p16+ group compared with p16- OPSCC. Conclusion The prognostic and predictive role of tumor immune microenvironment was confirmed for patients with OPSCC. Combining HPV status with the evaluation of densities of CD8(+)TILs and PD-L1 expression including TIM classification might be of high clinical interest and warrants further prospective evaluation.
ER  -

GURÍN, Dominik; Marek SLÁVIK; Markéta HERMANOVÁ; Iveta SELINGEROVÁ; Tomáš KAZDA; Michal HENDRYCH; Tetiana SHATOKHINA a Marcela VESELÁ. The tumor immune microenvironment and its implications for clinical outcome in patients with oropharyngeal squamous cell carcinoma. \textit{JOURNAL OF ORAL PATHOLOGY \&{} MEDICINE}. HOBOKEN: WILEY, 2020, roč.~49, č.~9, s.~886-896. ISSN~0904-2512. Dostupné z: https://doi.org/10.1111/jop.13055.

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