| VAŠKŮ, Vladimír, Anna VAŠKŮ, Lydie IZAKOVIČOVÁ HOLLÁ, Kateřina KAŇKOVÁ, Vladimír ZNOJIL, Věra SEMRÁDOVÁ a Jiří VÁCHA. Interaction of five gene polymorphism at psoriasis. The Journal of Investigative Dermatology. Cambridge: Blackwell Science Inc., roč. 113, č. 3, s. 494. ISSN 0022-202X. 1999. |
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@article{222346,
author = {Vašků, Vladimír and Vašků, Anna and Izakovičová Hollá, Lydie and Kaňková, Kateřina and Znojil, Vladimír and Semrádová, Věra and Vácha, Jiří},
article_location = {Cambridge},
article_number = {3},
keywords = {gene; polymorphism; TAP; TNF; endothelin; ACE},
language = {eng},
issn = {0022-202X},
journal = {The Journal of Investigative Dermatology},
title = {Interaction of five gene polymorphism at psoriasis},
volume = {113},
year = {1999}
}
TY - JOUR
ID - 222346
AU - Vašků, Vladimír - Vašků, Anna - Izakovičová Hollá, Lydie - Kaňková, Kateřina - Znojil, Vladimír - Semrádová, Věra - Vácha, Jiří
PY - 1999
TI - Interaction of five gene polymorphism at psoriasis
JF - The Journal of Investigative Dermatology
VL - 113
IS - 3
SP - 494
EP - 494
PB - Blackwell Science Inc.
SN - 0022202X
KW - gene
KW - polymorphism
KW - TAP
KW - TNF
KW - endothelin
KW - ACE
N2 - Associations among five gene polymorphism interactions and clinically manifested psoriasis were studied. All studied gene polymorphisms (endothelin-1-ET-1, transporters associated with antigen processing-TAP1, tumor necrosis factor beta-TNF beta, angiotensin I converting enzyme-ACE, advanced glycosylation end product-specific receptor- RAGE) were analyzed for their possible participation in the MHC class I cell surface antigen presentation to CD8+ T-cells. In psoriatic patients (n=153), the disequilibrium was found for coincidence of TNF beta with TAPl-333 ( P=0.016) as well as with TAP1-637 ( P=0.035). TNF beta was in disequilibrium with (ACE) polymorphism (P=0.036). ACE was observed to be in tight disequilibrium with TAP1-333 (p= 0.009) but not with TAP1-637 (P=0.133). The borderline significance of disequilibrium was found for ET-1 and RAGE gene polymorphisms (P=0.07).
ER -
VAŠKŮ, Vladimír, Anna VAŠKŮ, Lydie IZAKOVIČOVÁ HOLLÁ, Kateřina KAŇKOVÁ, Vladimír ZNOJIL, Věra SEMRÁDOVÁ a Jiří VÁCHA. Interaction of five gene polymorphism at psoriasis. \textit{The Journal of Investigative Dermatology}. Cambridge: Blackwell Science Inc., roč.~113, č.~3, s.~494. ISSN~0022-202X. 1999.
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