Oxidative stress, microparticles, and E-selectin do not depend on HIV suppression

HAVLÍČKOVÁ, Kateřina, Svatava SNOPKOVÁ, Miroslav POHANKA, Radek SVAČINKA, David VYDRÁŘ, Petr HUSA, Jiřina ZAVŘELOVÁ, Filip ZLÁMAL, Lenka FABIANOVÁ, Miroslav PENKA a Petr HUSA. Oxidative stress, microparticles, and E-selectin do not depend on HIV suppression. Biomedical Papers, Olomouc: Palacky University. Olomouc: Palacky University, 2024, roč. 168, č. 2, s. 1-9. ISSN 1213-8118. Dostupné z: https://dx.doi.org/10.5507/bp.2024.002.

Základní údaje

• Originální název: Oxidative stress, microparticles, and E-selectin do not depend on HIV suppression
• Autoři: HAVLÍČKOVÁ, Kateřina (203 Česká republika, garant, domácí), Svatava SNOPKOVÁ (203 Česká republika, domácí), Miroslav POHANKA (203 Česká republika, domácí), Radek SVAČINKA (203 Česká republika, domácí), David VYDRÁŘ (203 Česká republika, domácí), Petr HUSA (203 Česká republika, domácí), Jiřina ZAVŘELOVÁ (203 Česká republika, domácí), Filip ZLÁMAL (203 Česká republika, domácí), Lenka FABIANOVÁ (203 Česká republika, domácí), Miroslav PENKA (203 Česká republika, domácí) a Petr HUSA (203 Česká republika, domácí).
• Vydání: Biomedical Papers, Olomouc: Palacky University, Olomouc, Palacky University, 2024, 1213-8118.

Další údaje

• Originální jazyk: angličtina
• Typ výsledku: Článek v odborném periodiku
• Obor: 30303 Infectious Diseases
• Stát vydavatele: Česká republika
• Utajení: není předmětem státního či obchodního tajemství
• WWW: URL
• Impakt faktor: Impact factor: 0.900 v roce 2022
• Organizační jednotka: Lékařská fakulta
• Doi: http://dx.doi.org/10.5507/bp.2024.002
• UT WoS: 001171815400001
• Klíčová slova anglicky: oxidative stress; microparticles;E-selectin; HIV suppression

Anotace

Background. Oxidative stress and inflammation are considered predictors of diseases associated with aging. Markers of oxidative stress, inflammation, and endothelial activation were investigated in people with HIV on antiretroviral treatment to determine whether they had an immunosenescent phenotype that might predispose to the development of premature age-related diseases. Patients and Methods. This study was conducted on 213 subjects with HIV. The control groups consisted of healthy HIV-negative adults. The level of oxidative stress was measured by assessing the production of malondialdehyde levels, which were detected by thiobarbituric acid reactive substance (TBARS) assay. The level of microparticles indicated the presence of inflammation and endothelial activation was measured by E-selectin levels. Significant differences were determined by appropriate statistical tests, depending on the distribution of variables. Relationships between continuous variables were quantified using Spearman’s rank correlation coefficient. Results. TBARS, and microparticle and E-selectin levels were significantly higher in untreated and treated subjects with HIV compared with HIV-negative controls (P<0.001). The levels of the investigated markers were not significantly different between untreated and treated patients and no significant correlation of these markers was found with CD4+ count, CD4+/CD8+ ratio, and the number of HIV-1 RNA copies. Conclusions. Elevated markers of oxidative stress, inflammatory and endothelial activation were independent of the virologic and immunologic status of people with HIV. These results support the hypothesis that residual viremia in cellular reservoirs of various tissues is a key factor related to the premature aging of the immune system and predisposition to the premature development of diseases associated with aging.