Correlation of FSTL1 and its paralogs with body composition in
adult survivors of childhood cancer

J 2025

Correlation of FSTL1 and its paralogs with body composition in adult survivors of childhood cancer

ŠTRUBLOVÁ, Lucie; Filip ZLÁMAL; Tomáš PISKOVSKÝ; Jan KUČERA; Jana FIALOVÁ KUČEROVÁ et al.

Základní údaje

Originální název

Correlation of FSTL1 and its paralogs with body composition in adult survivors of childhood cancer

Autoři

ŠTRUBLOVÁ, Lucie ; Filip ZLÁMAL ; Tomáš PISKOVSKÝ; Jan KUČERA; Jana FIALOVÁ KUČEROVÁ; Tomáš KEPÁK; Jaroslav ŠTĚRBA a Julie DOBROVOLNÁ

Vydání

Scientific Reports, Berlin, NATURE RESEARCH, 2025, 2045-2322

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30204 Oncology

Stát vydavatele

Německo

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 3.900 v roce 2024

Označené pro přenos do RIV

Ano

Kód RIV

RIV/00216224:14110/25:00141529

Organizační jednotka

Lékařská fakulta

Klíčová slova anglicky

FSTL1; FSTL4; FSTL5; Adiposity; Skeletal muscle mass; Late effects; Childhood cancer survivors

Štítky

14110321, 14110518

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 2. 2. 2026 09:52, Mgr. Eva Suchánková

Anotace

V originále

This retrospective, cross-sectional study investigated the relationship between body composition and circulating plasma levels of follistatin-like proteins (FSTLs; FSTL1, FSTL4, and FSTL5) in adult survivors of childhood cancer. This is the first study to investigate the association between plasma levels of FSTL4, FSTL5 and skeletal muscle mass. The cohort consisted of 61 CCS (26 females and 35 males) aged 18-36 years (mean age 24.6 +/- 4.4 years) who were followed up at the Long-Term Follow-Up Clinic of St. Anne's Hospital in Brno, Czech Republic. The mean age at diagnosis was 10.9 +/- 4.9 years, and the mean time after treatment was 12.0 +/- 5.1 years. Body composition was assessed using anthropometric indicators and bioelectrical impedance analysis (BIA; InBody 370). Plasma FSTL levels were quantified using commercially available ELISA kits. Correlations were examined by linear regression analysis. A significant negative correlation was found between the FSTL1 plasma level and body fat mass index (BFMI), and a significant positive correlation was observed between FSTL1 and skeletal muscle mass index (SMI). Our results suggest that FSTL1 may be a potential indicator of adiposity and skeletal muscle loss in CCS.

Návaznosti

MUNI/A/1370/2022, interní kód MU

Název: Patofyziologie vybraných komplexních nemocí od molekulární do systémovou úroveň

Investor: Masarykova univerzita, Patofyziologie vybraných komplexních nemocí od molekulární do systémovou úroveň

MUNI/A/1790/2024, interní kód MU

Název: Patofyziologie běžných komplexních nemocí: od molekuly k organizmu

Investor: Masarykova univerzita, Patofyziologie běžných komplexních nemocí: od molekuly k organizmu

90249, velká výzkumná infrastruktura

Název: CZECRIN IV

Citovat

ŠTRUBLOVÁ, Lucie; Filip ZLÁMAL; Tomáš PISKOVSKÝ; Jan KUČERA; Jana FIALOVÁ KUČEROVÁ; Tomáš KEPÁK; Jaroslav ŠTĚRBA a Julie DOBROVOLNÁ. Correlation of FSTL1 and its paralogs with body composition in adult survivors of childhood cancer. Scientific Reports. Berlin: NATURE RESEARCH, 2025, roč. 15, č. 1, s. 1-9. ISSN 2045-2322. Dostupné z: https://doi.org/10.1038/s41598-025-03013-8.

@article{2507588,
   author = {Štrublová, Lucie and Zlámal, Filip and Piskovský, Tomáš and Kučera, Jan and Fialová Kučerová, Jana and Kepák, Tomáš and Štěrba, Jaroslav and Dobrovolná, Julie},
   article_location = {Berlin},
   article_number = {1},
   doi = {https://doi.org/10.1038/s41598-025-03013-8},
   keywords = {FSTL1; FSTL4; FSTL5; Adiposity; Skeletal muscle mass; Late effects; Childhood cancer survivors},
   language = {eng},
   issn = {2045-2322},
   journal = {Scientific Reports},
   title = {Correlation of FSTL1 and its paralogs with body composition in adult survivors of childhood cancer},
   url = {https://www.nature.com/articles/s41598-025-03013-8},
   volume = {15},
   year = {2025}
}

TY  - JOUR
ID  - 2507588
AU  - Štrublová, Lucie - Zlámal, Filip - Piskovský, Tomáš - Kučera, Jan - Fialová Kučerová, Jana - Kepák, Tomáš - Štěrba, Jaroslav - Dobrovolná, Julie
PY  - 2025
TI  - Correlation of FSTL1 and its paralogs with body composition in adult survivors of childhood cancer
JF  - Scientific Reports
VL  - 15
IS  - 1
SP  - 1-9
EP  - 1-9
PB  - NATURE RESEARCH
SN  - 20452322
KW  - FSTL1
KW  - FSTL4
KW  - FSTL5
KW  - Adiposity
KW  - Skeletal muscle mass
KW  - Late effects
KW  - Childhood cancer survivors
UR  - https://www.nature.com/articles/s41598-025-03013-8
N2  - This retrospective, cross-sectional study investigated the relationship between body composition and circulating plasma levels of follistatin-like proteins (FSTLs; FSTL1, FSTL4, and FSTL5) in adult survivors of childhood cancer. This is the first study to investigate the association between plasma levels of FSTL4, FSTL5 and skeletal muscle mass. The cohort consisted of 61 CCS (26 females and 35 males) aged 18-36 years (mean age 24.6 +/- 4.4 years) who were followed up at the Long-Term Follow-Up Clinic of St. Anne's Hospital in Brno, Czech Republic. The mean age at diagnosis was 10.9 +/- 4.9 years, and the mean time after treatment was 12.0 +/- 5.1 years. Body composition was assessed using anthropometric indicators and bioelectrical impedance analysis (BIA; InBody 370). Plasma FSTL levels were quantified using commercially available ELISA kits. Correlations were examined by linear regression analysis. A significant negative correlation was found between the FSTL1 plasma level and body fat mass index (BFMI), and a significant positive correlation was observed between FSTL1 and skeletal muscle mass index (SMI). Our results suggest that FSTL1 may be a potential indicator of adiposity and skeletal muscle loss in CCS.
ER  -

ŠTRUBLOVÁ, Lucie; Filip ZLÁMAL; Tomáš PISKOVSKÝ; Jan KUČERA; Jana FIALOVÁ KUČEROVÁ; Tomáš KEPÁK; Jaroslav ŠTĚRBA a Julie DOBROVOLNÁ. Correlation of FSTL1 and its paralogs with body composition in adult survivors of childhood cancer. \textit{Scientific Reports}. Berlin: NATURE RESEARCH, 2025, roč.~15, č.~1, s.~1-9. ISSN~2045-2322. Dostupné z: https://doi.org/10.1038/s41598-025-03013-8.

Přehled o publikaci