Long-term Subclinical Cardiotoxicity of Modern Cardiotoxic
Treatment Protocols in Childhood Cancer Survivors Assessed by
Cardiovascular Magnetic Resonance T1 Mapping and Circulatory
Biomarkers

J 2026

Long-term Subclinical Cardiotoxicity of Modern Cardiotoxic Treatment Protocols in Childhood Cancer Survivors Assessed by Cardiovascular Magnetic Resonance T1 Mapping and Circulatory Biomarkers

PANOVSKÝ, Roman; Marie TOMANDLOVÁ; Mary Luz MOJICA-PISCIOTTI; Tomáš KEPÁK; Jan MÁCHAL et al.

Základní údaje

Originální název

Long-term Subclinical Cardiotoxicity of Modern Cardiotoxic Treatment Protocols in Childhood Cancer Survivors Assessed by Cardiovascular Magnetic Resonance T1 Mapping and Circulatory Biomarkers

Autoři

Vydání

Cardiovascular Toxicology, Totowa, Humana Press, 2026, 1530-7905

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30201 Cardiac and Cardiovascular systems

Stát vydavatele

Spojené státy

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 3.700 v roce 2024

Označené pro přenos do RIV

Organizační jednotka

Lékařská fakulta

Klíčová slova anglicky

Cardiac magnetic resonance; Childhood cancer survivors; Anthracyclines; T1 mapping; Circulatory biomarkers

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 25. 2. 2026 09:47, Mgr. Tereza Miškechová

Anotace

V originále

Childhood cancer survivors (CCS) are at increased risk of developing heart disease due to the cardiotoxic effects of oncological treatment. This study aimed to investigate the long-term cardiotoxic effects of cancer therapy in CCS using a multimodal approach combining cardiac magnetic resonance (CMR) imaging and circulating blood biomarkers. A total of 117 CCS (mean age 24.7 +/- 5.2 years), at least five years post-treatment and in complete remission, were prospectively enrolled. All participants underwent CMR, including T1 mapping, and blood analysis for biomarkers of endothelial damage and oxidative stress. Parameters were compared with sex- and age-matched healthy control groups. Anthracycline treatment was administered in 82.9% of CCS (mean cumulative doxorubicin equivalent dose 231.7 +/- 92.0 mg/m(2)). Left ventricular ejection fraction and mitral annular plane systolic excursion were significantly reduced in CCS compared to controls (59.0 +/- 5.5% vs. 67.2 +/- 6.9%, p < 0.001; 12.5 +/- 1.7 mm vs. 13.9 +/- 2.2 mm, p = 0.001). Late gadolinium enhancement was detected in four CCS. No significant differences in global native T1 relaxation time or extracellular volume were observed. N-terminal pro-B-type natriuretic peptide (NT-proBNP) levels remained within normal limits but correlated with native T1, ECV, and MAPSE. Levels of myeloperoxidase, big endothelin-1, and ischemia-modified albumin were significantly higher than in controls. Subclinical myocardial changes were detected in long-term CCS using CMR and circulating biomarkers. These findings support the utility of a multimodal approach for the early identification of individuals at increased cardiovascular risk after childhood cancer treatment.

Návaznosti

LX22NPO5104, projekt VaV

Název: Národní institut pro výzkum metabolických a kardiovaskulárních onemocnění (Akronym: CarDia)

Investor: Ministerstvo školství, mládeže a tělovýchovy ČR, Národní institut pro léčbu metabolických a kardiovaskulárních onemocnění, 5.1 EXCELES

Citovat

PANOVSKÝ, Roman; Marie TOMANDLOVÁ; Mary Luz MOJICA-PISCIOTTI; Tomáš KEPÁK; Jan MÁCHAL; Vera FEITOVA; Jan FRIČ; Marcela HORTOVÁ KOHOUTKOVÁ; Tomáš HOLEČEK; Josef TOMANDL; Lukáš OPATŘIL a Vladimír KINCL. Long-term Subclinical Cardiotoxicity of Modern Cardiotoxic Treatment Protocols in Childhood Cancer Survivors Assessed by Cardiovascular Magnetic Resonance T1 Mapping and Circulatory Biomarkers. Cardiovascular Toxicology. Totowa: Humana Press, 2026, roč. 26, č. 2, s. 1-11. ISSN 1530-7905. Dostupné z: https://doi.org/10.1007/s12012-026-10098-8.

@article{2556620,
   author = {Panovský, Roman and Tomandlová, Marie and MojicaandPisciotti, Mary Luz and Kepák, Tomáš and Máchal, Jan and Feitova, Vera and Frič, Jan and Hortová Kohoutková, Marcela and Holeček, Tomáš and TOMANDL, Josef and Opatřil, Lukáš and Kincl, Vladimír},
   article_location = {Totowa},
   article_number = {2},
   doi = {https://doi.org/10.1007/s12012-026-10098-8},
   keywords = {Cardiac magnetic resonance; Childhood cancer survivors; Anthracyclines; T1 mapping; Circulatory biomarkers},
   language = {eng},
   issn = {1530-7905},
   journal = {Cardiovascular Toxicology},
   title = {Long-term Subclinical Cardiotoxicity of Modern Cardiotoxic Treatment Protocols in Childhood Cancer Survivors Assessed by Cardiovascular Magnetic Resonance T1 Mapping and Circulatory Biomarkers},
   url = {https://link.springer.com/article/10.1007/s12012-026-10098-8},
   volume = {26},
   year = {2026}
}

TY  - JOUR
ID  - 2556620
AU  - Panovský, Roman - Tomandlová, Marie - Mojica-Pisciotti, Mary Luz - Kepák, Tomáš - Máchal, Jan - Feitova, Vera - Frič, Jan - Hortová Kohoutková, Marcela - Holeček, Tomáš - TOMANDL, Josef - Opatřil, Lukáš - Kincl, Vladimír
PY  - 2026
TI  - Long-term Subclinical Cardiotoxicity of Modern Cardiotoxic Treatment Protocols in Childhood Cancer Survivors Assessed by Cardiovascular Magnetic Resonance T1 Mapping and Circulatory Biomarkers
JF  - Cardiovascular Toxicology
VL  - 26
IS  - 2
SP  - 1-11
EP  - 1-11
PB  - Humana Press
SN  - 15307905
KW  - Cardiac magnetic resonance
KW  - Childhood cancer survivors
KW  - Anthracyclines
KW  - T1 mapping
KW  - Circulatory biomarkers
UR  - https://link.springer.com/article/10.1007/s12012-026-10098-8
N2  - Childhood cancer survivors (CCS) are at increased risk of developing heart disease due to the cardiotoxic effects of oncological treatment. This study aimed to investigate the long-term cardiotoxic effects of cancer therapy in CCS using a multimodal approach combining cardiac magnetic resonance (CMR) imaging and circulating blood biomarkers. A total of 117 CCS (mean age 24.7 +/- 5.2 years), at least five years post-treatment and in complete remission, were prospectively enrolled. All participants underwent CMR, including T1 mapping, and blood analysis for biomarkers of endothelial damage and oxidative stress. Parameters were compared with sex- and age-matched healthy control groups. Anthracycline treatment was administered in 82.9% of CCS (mean cumulative doxorubicin equivalent dose 231.7 +/- 92.0 mg/m(2)). Left ventricular ejection fraction and mitral annular plane systolic excursion were significantly reduced in CCS compared to controls (59.0 +/- 5.5% vs. 67.2 +/- 6.9%, p < 0.001; 12.5 +/- 1.7 mm vs. 13.9 +/- 2.2 mm, p = 0.001). Late gadolinium enhancement was detected in four CCS. No significant differences in global native T1 relaxation time or extracellular volume were observed. N-terminal pro-B-type natriuretic peptide (NT-proBNP) levels remained within normal limits but correlated with native T1, ECV, and MAPSE. Levels of myeloperoxidase, big endothelin-1, and ischemia-modified albumin were significantly higher than in controls. Subclinical myocardial changes were detected in long-term CCS using CMR and circulating biomarkers. These findings support the utility of a multimodal approach for the early identification of individuals at increased cardiovascular risk after childhood cancer treatment.
ER  -

PANOVSKÝ, Roman; Marie TOMANDLOVÁ; Mary Luz MOJICA-PISCIOTTI; Tomáš KEPÁK; Jan MÁCHAL; Vera FEITOVA; Jan FRIČ; Marcela HORTOVÁ KOHOUTKOVÁ; Tomáš HOLEČEK; Josef TOMANDL; Lukáš OPATŘIL a Vladimír KINCL. Long-term Subclinical Cardiotoxicity of Modern Cardiotoxic Treatment Protocols in Childhood Cancer Survivors Assessed by Cardiovascular Magnetic Resonance T1 Mapping and Circulatory Biomarkers. \textit{Cardiovascular Toxicology}. Totowa: Humana Press, 2026, roč.~26, č.~2, s.~1-11. ISSN~1530-7905. Dostupné z: https://doi.org/10.1007/s12012-026-10098-8.

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