Outcomes of stereotactic body radiotherapy for bone
oligometastases in older patients - A European multicenter
cohort study

J 2026

Outcomes of stereotactic body radiotherapy for bone oligometastases in older patients - A European multicenter cohort study

NAGLER, Franziska; Sebastian SCHAFER; Isabell SEILER; von Wachter CAMILLA; Panagiotis BALERMPAS et al.

Základní údaje

Originální název

Outcomes of stereotactic body radiotherapy for bone oligometastases in older patients - A European multicenter cohort study

Autoři

Vydání

RADIOTHERAPY AND ONCOLOGY, CLARE, ELSEVIER IRELAND LTD, 2026, 0167-8140

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30204 Oncology

Stát vydavatele

Irsko

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 5.300 v roce 2024

Označené pro přenos do RIV

Ano

Organizační jednotka

Lékařská fakulta

Klíčová slova anglicky

Bone metastases; Stereotactic radiotherapy; SBRT; metastasis-directed therapy (MDT); Non-spine metastases; Spine metastases; Older patients

Štítky

14110812, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 5. 5. 2026 09:32, Mgr. Tereza Miškechová

Anotace

V originále

Introduction Outcome patterns for stereotactic body radiotherapy (SBRT) of bone oligometastases (BoM) especially for older patients are inadequately defined. We aimed to evaluate oncological outcomes and tolerability of SBRT for BoM in older patients. Material and methods Patients >= 70 years treated with SBRT for BoM between 2010 and 2024 at 20 European centers were analyzed and compared to patients <70 years. Outcomes included local recurrence (LR)/ freedom from LR (FFLR), progression-free survival (PFS), overall survival (OS), and adverse events. Results 789 patients with 1079 BoM were analyzed. Median age was 68 years (range: 19-91), and 355 patients (45.0%) were >= 70 years. Most common primary tumors were prostate (57.4%), breast (13.8%), and lung cancers (10.5%). LR at 3 years was 9.3% (CI: 6.0-12.8%) in patients <70 years and 11.7% (CI: 7.1-16.8%) in patients >= 70 years (p = 0.39). Grade-3 adverse events occurred in 1.8% of patients <70 years and 1.4% >= 70 years. No grade-4/5 adverse events were observed. Fracture rates were 2.9% for patients <70 years, and 1.8% >= 70 years. A higher metastatic volume was associated with reduced FFLR (Hazard ratio [HR] 1.006; p = 0.02), PFS (HR 1.003; p = 0.05), and OS (HR 1.003; p = 0.04). A better performance status was related to improved PFS (HR 0.98; p < 0.01) and OS (HR 0.96; p < 0.001), while age was not a significant factor. Conclusion This multicenter cohort analysis showed that SBRT of BoM is effective and well tolerated even in older patients. There were no significant differences in outcomes or side effects including fracture rates across patient age groups.

Citovat

NAGLER, Franziska; Sebastian SCHAFER; Isabell SEILER; von Wachter CAMILLA; Panagiotis BALERMPAS; Mauro LOI; Pierluigi BONOMO; Marek SLÁVIK; Petr BURKOŇ; Lena KASTNER; Johannes MEENTS; Fabian LOHAUS; Jochen WILLNER; Anna Sabrina SCHUNN; Sophia DRABKE; Kenneth KLISCHIES; Olaf WITTENSTEIN; Priska BANK; Richard PARTL; Jorg Andreas MULLER; Ahmed GAWISH; Arne GRUN; Andrea BAEHR; Maike TROMMER; Eleni GKIKA; Thomas MADER; Richard HOLY; Bernd FRERKER; Felix EHRET; Alexander RUHLE; Matthias GUCKENBERGER; Christos MOUSTAKIS; Thomas B BRUNNER; Oliver BLANCK; Judit BODA-HEGGEMANN a Nils H NICOLAY. Outcomes of stereotactic body radiotherapy for bone oligometastases in older patients - A European multicenter cohort study. RADIOTHERAPY AND ONCOLOGY. CLARE: ELSEVIER IRELAND LTD, 2026, roč. 219, June 2026, s. 1-10. ISSN 0167-8140. Dostupné z: https://doi.org/10.1016/j.radonc.2026.111485.

@article{2570538,
   author = {Nagler, Franziska and Schafer, Sebastian and Seiler, Isabell and Camilla, von Wachter and Balermpas, Panagiotis and Loi, Mauro and Bonomo, Pierluigi and Slávik, Marek and Burkoň, Petr and Kastner, Lena and Meents, Johannes and Lohaus, Fabian and Willner, Jochen and Schunn, Anna Sabrina and Drabke, Sophia and Klischies, Kenneth and Wittenstein, Olaf and Bank, Priska and Partl, Richard and Muller, Jorg Andreas and Gawish, Ahmed and Grun, Arne and Baehr, Andrea and Trommer, Maike and Gkika, Eleni and Mader, Thomas and Holy, Richard and Frerker, Bernd and Ehret, Felix and Ruhle, Alexander and Guckenberger, Matthias and Moustakis, Christos and Brunner, Thomas B and Blanck, Oliver and BodaandHeggemann, Judit and Nicolay, Nils H},
   article_location = {CLARE},
   article_number = {June 2026},
   doi = {https://doi.org/10.1016/j.radonc.2026.111485},
   keywords = {Bone metastases; Stereotactic radiotherapy; SBRT; metastasis-directed therapy (MDT); Non-spine metastases; Spine metastases; Older patients},
   language = {eng},
   issn = {0167-8140},
   journal = {RADIOTHERAPY AND ONCOLOGY},
   title = {Outcomes of stereotactic body radiotherapy for bone oligometastases in older patients - A European multicenter cohort study},
   url = {https://linkinghub.elsevier.com/retrieve/pii/S0167814026001246},
   volume = {219},
   year = {2026}
}

TY  - JOUR
ID  - 2570538
AU  - Nagler, Franziska - Schafer, Sebastian - Seiler, Isabell - Camilla, von Wachter - Balermpas, Panagiotis - Loi, Mauro - Bonomo, Pierluigi - Slávik, Marek - Burkoň, Petr - Kastner, Lena - Meents, Johannes - Lohaus, Fabian - Willner, Jochen - Schunn, Anna Sabrina - Drabke, Sophia - Klischies, Kenneth - Wittenstein, Olaf - Bank, Priska - Partl, Richard - Muller, Jorg Andreas - Gawish, Ahmed - Grun, Arne - Baehr, Andrea - Trommer, Maike - Gkika, Eleni - Mader, Thomas - Holy, Richard - Frerker, Bernd - Ehret, Felix - Ruhle, Alexander - Guckenberger, Matthias - Moustakis, Christos - Brunner, Thomas B - Blanck, Oliver - Boda-Heggemann, Judit - Nicolay, Nils H
PY  - 2026
TI  - Outcomes of stereotactic body radiotherapy for bone oligometastases in older patients - A European multicenter cohort study
JF  - RADIOTHERAPY AND ONCOLOGY
VL  - 219
IS  - June 2026
SP  - 1-10
EP  - 1-10
PB  - ELSEVIER IRELAND LTD
SN  - 01678140
KW  - Bone metastases
KW  - Stereotactic radiotherapy
KW  - SBRT
KW  - metastasis-directed therapy (MDT)
KW  - Non-spine metastases
KW  - Spine metastases
KW  - Older patients
UR  - https://linkinghub.elsevier.com/retrieve/pii/S0167814026001246
N2  - Introduction Outcome patterns for stereotactic body radiotherapy (SBRT) of bone oligometastases (BoM) especially for older patients are inadequately defined. We aimed to evaluate oncological outcomes and tolerability of SBRT for BoM in older patients. Material and methods Patients >= 70 years treated with SBRT for BoM between 2010 and 2024 at 20 European centers were analyzed and compared to patients <70 years. Outcomes included local recurrence (LR)/ freedom from LR (FFLR), progression-free survival (PFS), overall survival (OS), and adverse events. Results 789 patients with 1079 BoM were analyzed. Median age was 68 years (range: 19-91), and 355 patients (45.0%) were >= 70 years. Most common primary tumors were prostate (57.4%), breast (13.8%), and lung cancers (10.5%). LR at 3 years was 9.3% (CI: 6.0-12.8%) in patients <70 years and 11.7% (CI: 7.1-16.8%) in patients >= 70 years (p = 0.39). Grade-3 adverse events occurred in 1.8% of patients <70 years and 1.4% >= 70 years. No grade-4/5 adverse events were observed. Fracture rates were 2.9% for patients <70 years, and 1.8% >= 70 years. A higher metastatic volume was associated with reduced FFLR (Hazard ratio [HR] 1.006; p = 0.02), PFS (HR 1.003; p = 0.05), and OS (HR 1.003; p = 0.04). A better performance status was related to improved PFS (HR 0.98; p < 0.01) and OS (HR 0.96; p < 0.001), while age was not a significant factor. Conclusion This multicenter cohort analysis showed that SBRT of BoM is effective and well tolerated even in older patients. There were no significant differences in outcomes or side effects including fracture rates across patient age groups.
ER  -

NAGLER, Franziska; Sebastian SCHAFER; Isabell SEILER; von Wachter CAMILLA; Panagiotis BALERMPAS; Mauro LOI; Pierluigi BONOMO; Marek SLÁVIK; Petr BURKOŇ; Lena KASTNER; Johannes MEENTS; Fabian LOHAUS; Jochen WILLNER; Anna Sabrina SCHUNN; Sophia DRABKE; Kenneth KLISCHIES; Olaf WITTENSTEIN; Priska BANK; Richard PARTL; Jorg Andreas MULLER; Ahmed GAWISH; Arne GRUN; Andrea BAEHR; Maike TROMMER; Eleni GKIKA; Thomas MADER; Richard HOLY; Bernd FRERKER; Felix EHRET; Alexander RUHLE; Matthias GUCKENBERGER; Christos MOUSTAKIS; Thomas B BRUNNER; Oliver BLANCK; Judit BODA-HEGGEMANN a Nils H NICOLAY. Outcomes of stereotactic body radiotherapy for bone oligometastases in older patients - A European multicenter cohort study. \textit{RADIOTHERAPY AND ONCOLOGY}. CLARE: ELSEVIER IRELAND LTD, 2026, roč.~219, June 2026, s.~1-10. ISSN~0167-8140. Dostupné z: https://doi.org/10.1016/j.radonc.2026.111485.

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