Outcome of patients with lung cancer treated with stereotactic
body radiotherapy for bone oligometastases - a European
multicenter cohort study

J 2026

Outcome of patients with lung cancer treated with stereotactic body radiotherapy for bone oligometastases - a European multicenter cohort study

SCHAFER, Sebastian; Isabell SEILER; Panagiotis BALERMPAS; von Wachter CAMILLA; Mauro LOI et al.

Základní údaje

Originální název

Outcome of patients with lung cancer treated with stereotactic body radiotherapy for bone oligometastases - a European multicenter cohort study

Autoři

Vydání

Radiation Oncology, LONDON, BMC, 2026, 1748-717X

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30204 Oncology

Stát vydavatele

Velká Británie a Severní Irsko

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 3.200 v roce 2024

Označené pro přenos do RIV

Ano

Organizační jednotka

Lékařská fakulta

Klíčová slova anglicky

Bone metastases; Oligometastasis; Lung cancer; Stereotactic radiotherapy; Stereotactic body radiotherapy; SBRT; Metastasis-directed therapy; MDT

Štítky

14110812, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 1. 6. 2026 09:56, Mgr. Tereza Miškechová

Anotace

V originále

Introduction Metastasis-directed radiotherapy is of increasing importance in the multidisciplinary management of oligometastatic non-small cell lung cancer (NSCLC), but outcome patterns for stereotactic body radiotherapy (SBRT) of bone oligometastases (BoM) remain insufficiently defined. We aimed to determine oncological outcomes and prognostic factors of SBRT for BoM of NSCLC. Materials and methods Patients with NSCLC treated with SBRT for < 5 BoM between 2010 and 2024 at 15 European cancer centers were retrospectively analyzed. Outcomes included freedom from local recurrence (FFLR), progression-free survival (PFS), overall survival (OS), and adverse events. Results With a median follow-up of 14 months (IQR: 7-24 months), 85 patients with 111 treated BoM were analyzed. The 2-year FFLR was 87.2% (95%-CI: 73.3%-94.1%). The 1-/2-year PFS for singular BoM was 60.1% (CI: 44.6%-72.5%)/ 39.9% (CI: 24.6%-54.8%), while for 2-3 BoM they amounted to 10.2% (95%-CI: 0.6%-35.8%) and 0%. In multivariable analysis, less favorable outcome for OS and PFS was associated with larger BoM (HR 1.003; p < 0.01 and HR 1.005, p < 0.001) and increased number of treated BoM (HR 1.72; p = 0.03 and HR 1.93;p<0.01).Treatment was well tolerated, with fracture rates of 5.4% and no grade 4 and 5 adverse events. Conclusion This multicenter cohort analysis revealed that SBRT of BoM from NSCLC appears to be an effective and well-tolerated treatment. Presence of singular BoM was a favorable prognostic factor. Prospective studies are needed to confirm these findings and to determine the role of SBRT in the multidisciplinary management of oligometastases.

Citovat

SCHAFER, Sebastian; Isabell SEILER; Panagiotis BALERMPAS; von Wachter CAMILLA; Mauro LOI; Daniela GRETO; Anna Sabrina SCHUNN; Sophia DRABKE; Kenneth KLISCHIES; Olaf WITTENSTEIN; Jochen WILLNER; Fabian LOHAUS; Lena KASTNER; Johannes MEENTS; Priska BANK; Marek SLÁVIK; Petr BURKOŇ; Richard PARTL; Jorg Andreas MULLER; Yvonne DZIERMA; Thomas MADER; Maike TROMMER; Eleni GKIKA; Alexander RUHLE; Matthias GUCKENBERGER; Christos MOUSTAKIS; Thomas BRUNNER; Oliver BLANCK; Judit BODA-HEGGEMANN; Nils H NICOLAY a Franziska NAGLER. Outcome of patients with lung cancer treated with stereotactic body radiotherapy for bone oligometastases - a European multicenter cohort study. Radiation Oncology. LONDON: BMC, 2026, roč. 21, č. 1, s. 1-12. ISSN 1748-717X. Dostupné z: https://doi.org/10.1186/s13014-026-02855-4.

@article{2576320,
   author = {Schafer, Sebastian and Seiler, Isabell and Balermpas, Panagiotis and Camilla, von Wachter and Loi, Mauro and Greto, Daniela and Schunn, Anna Sabrina and Drabke, Sophia and Klischies, Kenneth and Wittenstein, Olaf and Willner, Jochen and Lohaus, Fabian and Kastner, Lena and Meents, Johannes and Bank, Priska and Slávik, Marek and Burkoň, Petr and Partl, Richard and Muller, Jorg Andreas and Dzierma, Yvonne and Mader, Thomas and Trommer, Maike and Gkika, Eleni and Ruhle, Alexander and Guckenberger, Matthias and Moustakis, Christos and Brunner, Thomas and Blanck, Oliver and BodaandHeggemann, Judit and Nicolay, Nils H and Nagler, Franziska},
   article_location = {LONDON},
   article_number = {1},
   doi = {https://doi.org/10.1186/s13014-026-02855-4},
   keywords = {Bone metastases; Oligometastasis; Lung cancer; Stereotactic radiotherapy; Stereotactic body radiotherapy; SBRT; Metastasis-directed therapy; MDT},
   language = {eng},
   issn = {1748-717X},
   journal = {Radiation Oncology},
   title = {Outcome of patients with lung cancer treated with stereotactic body radiotherapy for bone oligometastases - a European multicenter cohort study},
   url = {https://link.springer.com/article/10.1186/s13014-026-02855-4},
   volume = {21},
   year = {2026}
}

TY  - JOUR
ID  - 2576320
AU  - Schafer, Sebastian - Seiler, Isabell - Balermpas, Panagiotis - Camilla, von Wachter - Loi, Mauro - Greto, Daniela - Schunn, Anna Sabrina - Drabke, Sophia - Klischies, Kenneth - Wittenstein, Olaf - Willner, Jochen - Lohaus, Fabian - Kastner, Lena - Meents, Johannes - Bank, Priska - Slávik, Marek - Burkoň, Petr - Partl, Richard - Muller, Jorg Andreas - Dzierma, Yvonne - Mader, Thomas - Trommer, Maike - Gkika, Eleni - Ruhle, Alexander - Guckenberger, Matthias - Moustakis, Christos - Brunner, Thomas - Blanck, Oliver - Boda-Heggemann, Judit - Nicolay, Nils H - Nagler, Franziska
PY  - 2026
TI  - Outcome of patients with lung cancer treated with stereotactic body radiotherapy for bone oligometastases - a European multicenter cohort study
JF  - Radiation Oncology
VL  - 21
IS  - 1
SP  - 1-12
EP  - 1-12
PB  - BMC
SN  - 1748717X
KW  - Bone metastases
KW  - Oligometastasis
KW  - Lung cancer
KW  - Stereotactic radiotherapy
KW  - Stereotactic body radiotherapy
KW  - SBRT
KW  - Metastasis-directed therapy
KW  - MDT
UR  - https://link.springer.com/article/10.1186/s13014-026-02855-4
N2  - Introduction Metastasis-directed radiotherapy is of increasing importance in the multidisciplinary management of oligometastatic non-small cell lung cancer (NSCLC), but outcome patterns for stereotactic body radiotherapy (SBRT) of bone oligometastases (BoM) remain insufficiently defined. We aimed to determine oncological outcomes and prognostic factors of SBRT for BoM of NSCLC. Materials and methods Patients with NSCLC treated with SBRT for < 5 BoM between 2010 and 2024 at 15 European cancer centers were retrospectively analyzed. Outcomes included freedom from local recurrence (FFLR), progression-free survival (PFS), overall survival (OS), and adverse events. Results With a median follow-up of 14 months (IQR: 7-24 months), 85 patients with 111 treated BoM were analyzed. The 2-year FFLR was 87.2% (95%-CI: 73.3%-94.1%). The 1-/2-year PFS for singular BoM was 60.1% (CI: 44.6%-72.5%)/ 39.9% (CI: 24.6%-54.8%), while for 2-3 BoM they amounted to 10.2% (95%-CI: 0.6%-35.8%) and 0%. In multivariable analysis, less favorable outcome for OS and PFS was associated with larger BoM (HR 1.003; p < 0.01 and HR 1.005, p < 0.001) and increased number of treated BoM (HR 1.72; p = 0.03 and HR 1.93;p<0.01).Treatment was well tolerated, with fracture rates of 5.4% and no grade 4 and 5 adverse events. Conclusion This multicenter cohort analysis revealed that SBRT of BoM from NSCLC appears to be an effective and well-tolerated treatment. Presence of singular BoM was a favorable prognostic factor. Prospective studies are needed to confirm these findings and to determine the role of SBRT in the multidisciplinary management of oligometastases.
ER  -

SCHAFER, Sebastian; Isabell SEILER; Panagiotis BALERMPAS; von Wachter CAMILLA; Mauro LOI; Daniela GRETO; Anna Sabrina SCHUNN; Sophia DRABKE; Kenneth KLISCHIES; Olaf WITTENSTEIN; Jochen WILLNER; Fabian LOHAUS; Lena KASTNER; Johannes MEENTS; Priska BANK; Marek SLÁVIK; Petr BURKOŇ; Richard PARTL; Jorg Andreas MULLER; Yvonne DZIERMA; Thomas MADER; Maike TROMMER; Eleni GKIKA; Alexander RUHLE; Matthias GUCKENBERGER; Christos MOUSTAKIS; Thomas BRUNNER; Oliver BLANCK; Judit BODA-HEGGEMANN; Nils H NICOLAY a Franziska NAGLER. Outcome of patients with lung cancer treated with stereotactic body radiotherapy for bone oligometastases - a European multicenter cohort study. \textit{Radiation Oncology}. LONDON: BMC, 2026, roč.~21, č.~1, s.~1-12. ISSN~1748-717X. Dostupné z: https://doi.org/10.1186/s13014-026-02855-4.

Přehled o publikaci