ACE gene I/D polymorphism and pulmonary disease severity in UK
and Czech sarcoidosis populations

J 2001

ACE gene I/D polymorphism and pulmonary disease severity in UK and Czech sarcoidosis populations

MCGRATH, Deirdre, Patrick J FOLEY, Martin PETREK, Lydie IZAKOVIČOVÁ HOLLÁ, Vítězslav KOLEK et. al.

Základní údaje

Originální název

ACE gene I/D polymorphism and pulmonary disease severity in UK and Czech sarcoidosis populations

Autoři

MCGRATH, Deirdre (826 Velká Británie a Severní Irsko), Patrick J FOLEY (826 Velká Británie a Severní Irsko), Martin PETREK (203 Česká republika), Lydie IZAKOVIČOVÁ HOLLÁ (203 Česká republika, garant), Vítězslav KOLEK (203 Česká republika), Srihari VEERARAGHAVAN, Penelope A LYMPANY, Panagiotis PANTELIDIS, Anna VAŠKŮ (203 Česká republika), Athol U WELLS, Kenneth I WELSH a Roland M DU BOIS (826 Velká Británie a Severní Irsko)

Vydání

Am.J.Respir.Crit.Care Med, Chicago, American Thoracic Society, 2001, 1073-449X

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30203 Respiratory systems

Stát vydavatele

Spojené státy

Utajení

není předmětem státního či obchodního tajemství

Impakt faktor

Impact factor: 5.956

Kód RIV

RIV/00216224:14110/01:00004178

Organizační jednotka

Lékařská fakulta

UT WoS

000170275300006

Klíčová slova anglicky

gene; polymorphism; ACE; sarcoidosis; severity; disease susceptibility

Štítky

ACE, disease susceptibility, gene, polymorphism, sarcoidosis, severity

Změněno: 17. 6. 2009 12:57, prof. MUDr. Lydie Izakovičová Hollá, Ph.D.

Anotace

V originále

Previous studies of the Insertion/Deletion (I/D) polymorphism of the Angiotensin-Converting Enzyme (ACE) gene in sarcoidosis have revealed both ethnic heterogeneity of I/D frequencies and controversy surrounding the association between the polymorphism and severity of disease. The objective of this study was, therefore, to clarify the role of the ACE I/D polymorphism in, 1) disease susceptibility, 2) pulmonary disease severity (with particular reference to pulmonary fibrosis) and 3) pulmonary disease progression, in two distinct European sarcoidosis populations.

Návaznosti

MSM 141100002, záměr

Název: Molekulární patofyziologie multigenních chorob

Investor: Ministerstvo školství, mládeže a tělovýchovy ČR, Molekulární patofyziologie multigenních chorob

Citovat

MCGRATH, Deirdre, Patrick J FOLEY, Martin PETREK, Lydie IZAKOVIČOVÁ HOLLÁ, Vítězslav KOLEK, Srihari VEERARAGHAVAN, Penelope A LYMPANY, Panagiotis PANTELIDIS, Anna VAŠKŮ, Athol U WELLS, Kenneth I WELSH a Roland M DU BOIS. ACE gene I/D polymorphism and pulmonary disease severity in UK and Czech sarcoidosis populations. Am.J.Respir.Crit.Care Med. Chicago: American Thoracic Society, 2001, roč. 164, č. 2, s. 197-201. ISSN 1073-449X.

@article{361752,
   author = {McGrath, Deirdre and Foley, Patrick J and Petrek, Martin and Izakovičová Hollá, Lydie and Kolek, Vítězslav and Veeraraghavan, Srihari and Lympany, Penelope A and Pantelidis, Panagiotis and Vašků, Anna and Wells, Athol U and Welsh, Kenneth I and du Bois, Roland M},
   article_location = {Chicago},
   article_number = {2},
   keywords = {gene; polymorphism; ACE; sarcoidosis; severity; disease susceptibility},
   language = {eng},
   issn = {1073-449X},
   journal = {Am.J.Respir.Crit.Care Med},
   title = {ACE gene I/D polymorphism and pulmonary disease severity in UK and Czech sarcoidosis populations},
   volume = {164},
   year = {2001}
}

TY  - JOUR
ID  - 361752
AU  - McGrath, Deirdre - Foley, Patrick J - Petrek, Martin - Izakovičová Hollá, Lydie - Kolek, Vítězslav - Veeraraghavan, Srihari - Lympany, Penelope A - Pantelidis, Panagiotis - Vašků, Anna - Wells, Athol U - Welsh, Kenneth I - du Bois, Roland M
PY  - 2001
TI  - ACE gene I/D polymorphism and pulmonary disease severity in UK and Czech sarcoidosis populations
JF  - Am.J.Respir.Crit.Care Med
VL  - 164
IS  - 2
SP  - 197
EP  - 197
PB  - American Thoracic Society
SN  - 1073449X
KW  - gene
KW  - polymorphism
KW  - ACE
KW  - sarcoidosis
KW  - severity
KW  - disease susceptibility
N2  - Previous studies of the Insertion/Deletion (I/D) polymorphism of the Angiotensin-Converting Enzyme (ACE) gene in sarcoidosis have revealed both ethnic heterogeneity of I/D frequencies and controversy surrounding the association between the polymorphism and severity of disease. The objective of this study was, therefore, to clarify the role of the ACE I/D polymorphism in, 1) disease susceptibility, 2) pulmonary disease severity (with particular reference to pulmonary fibrosis) and 3) pulmonary disease progression, in two distinct European sarcoidosis populations.
ER  -

MCGRATH, Deirdre, Patrick J FOLEY, Martin PETREK, Lydie IZAKOVIČOVÁ HOLLÁ, Vítězslav KOLEK, Srihari VEERARAGHAVAN, Penelope A LYMPANY, Panagiotis PANTELIDIS, Anna VAŠKŮ, Athol U WELLS, Kenneth I WELSH a Roland M DU BOIS. ACE gene I/D polymorphism and pulmonary disease severity in UK and Czech sarcoidosis populations. \textit{Am.J.Respir.Crit.Care Med}. Chicago: American Thoracic Society, 2001, roč.~164, č.~2, s.~197-201. ISSN~1073-449X.

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