Plasminogen-Activator-Inhibitor-1 Promoter Polymorphism as a
Risk Factor for Adult Periodontitis in Non-Smokers

J 2002

Plasminogen-Activator-Inhibitor-1 Promoter Polymorphism as a Risk Factor for Adult Periodontitis in Non-Smokers

IZAKOVIČOVÁ HOLLÁ, Lydie, Dana BUČKOVÁ, Antonín FASSMANN, Petr BENEŠ, Vladimír ZNOJIL et. al.

Základní údaje

Originální název

Plasminogen-Activator-Inhibitor-1 Promoter Polymorphism as a Risk Factor for Adult Periodontitis in Non-Smokers

Autoři

IZAKOVIČOVÁ HOLLÁ, Lydie (203 Česká republika, garant), Dana BUČKOVÁ (203 Česká republika), Antonín FASSMANN (203 Česká republika), Petr BENEŠ (203 Česká republika) a Vladimír ZNOJIL (203 Česká republika)

Vydání

Genes Immun, United Kingdom, Nature Publishing Group, 2002, 1466-4879

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30200 3.2 Clinical medicine

Stát vydavatele

Velká Británie a Severní Irsko

Utajení

není předmětem státního či obchodního tajemství

Impakt faktor

Impact factor: 3.060

Kód RIV

RIV/00216224:14110/02:00005507

Organizační jednotka

Lékařská fakulta

UT WoS

000177380000007

Klíčová slova anglicky

gene; polymorphism; PAI-1; periodontitis

Štítky

gene, PAI-1, periodontitis, polymorphism

Změněno: 17. 6. 2009 12:39, prof. MUDr. Lydie Izakovičová Hollá, Ph.D.

Anotace

V originále

Periodontal diseases belong to the most common chronic disorders affecting mankind. Smoking and impaired plasminogen activation with hypercoagulation and fibrinolysis inhibition have been proposed as having a role in predisposition to these diseases We investigated relationships among adult periodontitis, smoking and a variation in the deletion/insertion (4G/5G) promoter polymorphism of the plasminogen-activator-inhibitor-1 (PAI-1) gene in 304 Caucasian subjects. An association was detected between the deletion (4G) allele (and 4G/4G genotype) and periodontitis (p=0.0022, Pcorr.LT.0.01, p=0.014, Pcorr.LT.0.05). Even a stronger association occurred in non-smokers (p=0.00021, Pcorr.LT.0.01, p=0.0024, Pcorr.LT.0.05) where the presence of the PAI-1 gene 4G allele appears to be one of the risk factors for periodontitis.

Návaznosti

MSM 141100002, záměr

Název: Molekulární patofyziologie multigenních chorob

Investor: Ministerstvo školství, mládeže a tělovýchovy ČR, Molekulární patofyziologie multigenních chorob

Citovat

IZAKOVIČOVÁ HOLLÁ, Lydie, Dana BUČKOVÁ, Antonín FASSMANN, Petr BENEŠ a Vladimír ZNOJIL. Plasminogen-Activator-Inhibitor-1 Promoter Polymorphism as a Risk Factor for Adult Periodontitis in Non-Smokers. Genes Immun. United Kingdom: Nature Publishing Group, 2002, roč. 3, č. 5, s. 292-294. ISSN 1466-4879.

@article{395771,
   author = {Izakovičová Hollá, Lydie and Bučková, Dana and Fassmann, Antonín and Beneš, Petr and Znojil, Vladimír},
   article_location = {United Kingdom},
   article_number = {5},
   keywords = {gene; polymorphism; PAI-1; periodontitis},
   language = {eng},
   issn = {1466-4879},
   journal = {Genes Immun},
   title = {Plasminogen-Activator-Inhibitor-1 Promoter Polymorphism as a Risk Factor for Adult Periodontitis in Non-Smokers},
   volume = {3},
   year = {2002}
}

TY  - JOUR
ID  - 395771
AU  - Izakovičová Hollá, Lydie - Bučková, Dana - Fassmann, Antonín - Beneš, Petr - Znojil, Vladimír
PY  - 2002
TI  - Plasminogen-Activator-Inhibitor-1 Promoter Polymorphism as a Risk Factor for Adult Periodontitis in Non-Smokers
JF  - Genes Immun
VL  - 3
IS  - 5
SP  - 292
EP  - 292
PB  - Nature Publishing Group
SN  - 14664879
KW  - gene
KW  - polymorphism
KW  - PAI-1
KW  - periodontitis
N2  - Periodontal diseases belong to the most common chronic disorders affecting mankind. Smoking and impaired plasminogen activation with hypercoagulation and fibrinolysis inhibition have been proposed as having a role in predisposition to these diseases We investigated relationships among adult periodontitis, smoking and a variation in the deletion/insertion (4G/5G) promoter polymorphism of the plasminogen-activator-inhibitor-1 (PAI-1) gene in 304 Caucasian subjects. An association was detected between the deletion (4G) allele (and 4G/4G genotype) and periodontitis (p=0.0022, Pcorr.LT.0.01, p=0.014, Pcorr.LT.0.05). Even a stronger association occurred in non-smokers (p=0.00021, Pcorr.LT.0.01, p=0.0024, Pcorr.LT.0.05) where the presence of the PAI-1 gene 4G allele appears to be one of the risk factors for periodontitis.
ER  -

IZAKOVIČOVÁ HOLLÁ, Lydie, Dana BUČKOVÁ, Antonín FASSMANN, Petr BENEŠ a Vladimír ZNOJIL. Plasminogen-Activator-Inhibitor-1 Promoter Polymorphism as a Risk Factor for Adult Periodontitis in Non-Smokers. \textit{Genes Immun}. United Kingdom: Nature Publishing Group, 2002, roč.~3, č.~5, s.~292-294. ISSN~1466-4879.

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