2003
Relationship between genetic polymorphism of antioxidant enzymes and diabetic complications
KAŇKOVÁ, Kateřina, Ivana MÁROVÁ a Andrea STEJSKALOVÁZákladní údaje
Originální název
Relationship between genetic polymorphism of antioxidant enzymes and diabetic complications
Název česky
Vztah mezi genetickym polymorfizmem v antioxidacnim systemu a diabetickymi komplikacemi
Autoři
KAŇKOVÁ, Kateřina (203 Česká republika, garant), Ivana MÁROVÁ (203 Česká republika) a Andrea STEJSKALOVÁ (203 Česká republika)
Vydání
London, Great Britain, Stress, Signalling and Control, s. 59-59, 2003
Nakladatel
Biochemical Society
Další údaje
Jazyk
angličtina
Typ výsledku
Stať ve sborníku
Obor
30202 Endocrinology and metabolism
Stát vydavatele
Velká Británie a Severní Irsko
Utajení
není předmětem státního či obchodního tajemství
Kód RIV
RIV/00216224:14110/03:00008083
Organizační jednotka
Lékařská fakulta
Klíčová slova anglicky
diabetes mellitus; complications; polymorphism; antioxidant
Změněno: 11. 2. 2005 12:55, prof. MUDr. Kateřina Kaňková, Ph.D.
V originále
Background and Aims: Association of genetic polymorphisms in glyoxalase I (A111E GLYI), paraoxonase (-107C/T, M55L and R192Q PON) and NAD(P)H: quinone oxidoreductase genes (P187S NQO1) with diabetes-associated microvascular dermatoses (DAMD) in patients with type 2 diabetes mellitus and analogical microvascular dermatoses (MD) in non-diabetics was studied. Materials and Methods: A total of 456 subjects was enrolled in the association study comprising four groups of subjects: diabetics with and without DAMD and non-diabetics with and without MD. Results: Significant difference in genotype frequencies of the A111E GLYI between DAMD and non-DAMD group was found; frequency of the E allele was higher in DAMD group (58.8% vs. 55.6%). Moreover, marginally significant association of allele M with DAMD was detected for the M55L PON polymorphism (P=0.062); 67.3% in DAMD vs. 59.6% in non-DAMD group. When both DAMD/MD group pooled together, association of GLYI 111E and PON 55M with cutaneous manifestation was proved irrespective of diabetes (P=0.018 and 0.021, respectively). Frequencies of A111E GLY1 and M55L PON haplotypes were significantly different between DAMD/MD and non- DAMD/MD groups (P=0.016). Conclusions: Polymorphisms in genes encoding antioxidant enzymes could belong to cluster of genetic susceptibility risk factors for diabetic complications.
Česky
Polymorfizmus v genech kodujicich antioxidacni enzymy nalezi ke skupine genetickych rizikovych faktoru pro diabeticke komplikace.
Návaznosti
| GP303/02/D127, projekt VaV |
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| MSM 141100002, záměr |
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